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Low-Powered pH-Stable Nano-electrokinetically Enhanced Lateral Flow Assay for COVID-19 Antigen Test
Kim Kang Hyeon,유용경,Lee Na Eun,Lee Junwoo,Kim Cheonjung,Lee Seungmin,Kim Jinhwan,Park Seong Jun,Lee Dongtak,이상원,Kim Hyungseok,허돈,Yoon Dae Sung,Lee Jeong Hoon 한국바이오칩학회 2023 BioChip Journal Vol.17 No.3
Lateral fl ow assay (LFA) is a popular diagnostic system used in point-of-care testing (POCT) due to its low cost and portability. However, LFA has limited sensitivity and detection limits, making it challenging to detect low virus titers. Preconcentration through nano-electrokinetic (NEK) techniques have been proposed as a promising solution to improve the sensitivity of LFA. Nevertheless, the acidic conditions used in NEK operations may reduce the specifi city and sensitivity of LFA immunoassays. To address these limitations, an integrated LFA kit, the NEK-enhanced LFA (PcNEK–LFA), has been introduced. This kit features a pH-controlled structure designed to facilitate sample preconcentration. Biomarkers and AuNPs are electrokinetically preconcentrated in the PcNEK–LFA platform to increase the concentration of the test line and Ag–Ab binding events, resulting in enhanced performance. The pH-controlled PcNEK–LFA platform was evaluated using salivary human chorionic gonadotropin beta (β-hCG) and COVID-19 Ag samples, achieving a preconcentrating factor of approximately 10 and a sensitivity enhancement of 55.42%, and a preconcentrating factor greater than 10, respectively. The pH-controlled PcNEK–LFA platform provides an eff ective solution to overcome the limitations of LFA for POCT. In addition, it improves its sensitivity and detection limit, signifi cantly enhancing the accuracy and reliability of POCT, particularly for COVID-19 screening tests. As a result, this platform may play a pivotal role in addressing current and future healthcare challenges, facilitating rapid diagnosis and treatment of infectious diseases.
효율적인 인터넷 범죄수사를 위한 범행호스트 탐지 및 범죄행위 입증기술
김형석(Hyungseok Kim),김은진(Eunjin Kim),김휘강(Huy Kang Kim) 한국정보보호학회 2012 정보보호학회논문지 Vol.22 No.4
인터넷범죄를 수사함에 있어 가장 중요한 점은 범행호스트의 범행을 입증하는 것이다. 그러나 범죄자들은 범행부인을 위해 범행호스트의 IP주소를 변경하거나 패킷의 출발지 IP주소를 조작한다. 또한 악의적인 어플리케이션을 이용하여 범행기록을 남기지 않는다. 본 논문은 인터넷범죄수사의 한계를 극복하기 위한 Network Forensic Evidence Generation and Verification Scheme을 제안한다. 이 기술은 인터넷범죄수사를 위해 패킷의 생성위치와 전송과정에 주소필드가 조작되지 않았음을 보장하는 증거를 생성하여, 범행기록이 부재하여도 패킷을 통해 입증한다. 그리고 증거생성에 의한 라우터의 성능저하를 최소화하기 위해 Timestamp SecretKey Distribution Scheme과 Flow-Based Selection Scheme을 추가 제안한다. 마지막으로 제안한 기술들을 활용하기 위한 시스템을 구현하고 패킷전송률을 실험한다. One of the most important point in the Internet crime investigation is tracing back and pointing out a criminal host. However, criminals can forge a crime record stored in the crime host, or can utilize malicious applications in order not to leave a crime record. In addition, criminals can change the source IP address of a crime host and deny their involvement. In this study, we suggests the Network Forensic Evidence Generation and Verification Scheme (NFEGVS) to rectify the current limitation of Network Forensic technologies. This scheme can prove who and when the crime has occurred. In addition, this prevents leaking of symmetric key for guaranteeing certification and integrity of Forensic Evidence by proposing the Timestamp Secret Key Distribution Scheme, and minimizes performance degradation of router when generating forensic evidence with the Flow-Based Selection Scheme. In this paper, we implement the proposed scheme and evaluate overall performance of the proposed system.
Executive Compensation When a Firm is a Business Group Member
Hyungseok Kim,Woochan Kim 한국재무학회 2014 한국재무학회 학술대회 Vol.2014 No.05
This paper examines how executive pay is set when a firm is a business group member. Using Korea as a laboratory setting, we find that member firm’s cash compensation for its executives is strongly linked to the stock performance of other members as well as its own. Further analyses reveal that this link to other members’ performance is consistent with the hypothesis of corporate resources being tunneled from one member to another for the benefit of the controlling family. We find that the link is stronger in firms with high control-ownership disparity or low foreign ownership. We also find that the link is tighter to the performance of firms directly owned by the controlling family.
GM-CSF Promotes Antitumor Immunity by Inducing Th9 Cell Responses
Kim, Il-Kyu,Koh, Choong-Hyun,Jeon, Insu,Shin, Kwang-Soo,Kang, Tae-Seung,Bae, Eun-Ah,Seo, Hyungseok,Ko, Hyun-Ja,Kim, Byung-Seok,Chung, Yeonseok,Kang, Chang-Yuil American Association for Cancer Research 2019 Cancer immunology research Vol.7 No.3
<P>Granulocyte-macrophage colony-stimulating factor (GM-CSF) functions as an adjuvant for antitumor immunity through an unclear mechanism. By activating monocyte-derived dendritic cells, GM-CSF induces Th9 development and IL9 production, which facilitates antitumor cytotoxic T lymphocyte responses.</P><P>GM-CSF as an adjuvant has been shown to promote antitumor immunity in mice and humans; however, the underlying mechanism of GM-CSF–induced antitumor immunity remains incompletely understood. In this study, we demonstrate that GM-CSF potentiates the efficacy of cancer vaccines through IL9-producing Th (Th9) cells. GM-CSF selectively enhanced Th9 cell differentiation by regulating the COX2–PGE<SUB>2</SUB> pathway while inhibiting the differentiation of induced regulatory T (iTreg) cells <I>in vitro</I> and <I>in vivo</I>. GM-CSF–activated monocyte-derived dendritic cells converted tumor-specific nai¨ve Th cells into Th9 cells, and delayed tumor growth by inducing antitumor CTLs in an IL9-dependent manner. Our findings reveal a mechanism for the adjuvanticity of GM-CSF and provide a rationale for the use of GM-CSF in cancer vaccines.</P>