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RISS 인기검색어
- 검색키워드
- 저자 : Huai Chang Yu (검색결과 3 건)
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- 유료
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Huai Chang Yu,Han Dong Liu,Zhi Quan Huang,Guang Cheng Shi 대한토목학회 2017 KSCE Journal of Civil Engineering Vol.21 No.3
Short-term and creep tests were performed on saturated silty mudstone obtained from the Three Gorges Reservoir area. Based on the triaxial creep test results, the variations of creep strain and creep rate of silty mudstone with time were analyzed in detail, and the differences between the axial and lateral creep parameters were quantitatively studied at different deviatoric stress levels. The longterm strength of silty mudstone was obtained. The results demonstrate that the lateral creep characteristics are more significant than the axial creep characteristics for silty mudstone in the tests. Analysis of the lateral creep characteristics of the rock is a reasonable approach to determine whether creep failure occurs in the silty mudstone. The long-term strength of silty mudstone decreases remarkably, and it is actually the lateral long-term strength of the rock. According to the triaxial creep curves of silty mudstone, a new nonlinear viscoelasto-plastic creep model was proposed by connecting in series the nonlinear viscoplastic body with the sixcomponent model. Comparing the model curves with test results, this model was determined to reflect the creep properties of silty mudstone accurately. Finally, the selection of the creep model parameters was achieved by considering the axial and lateral creep characteristics of silty mudstone.
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Che Yu Kuo,Kao Chin Chen,I Hui Lee,Huai-Hsuan Tseng,Nan Tsing Chiu,Po See Chen,Yen Kuang Yang,Wei Hung Chang 대한정신약물학회 2022 CLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE Vol.20 No.2
Objective: The impact of serotonergic system on obsessive-compulsive disorder (OCD) is well studied. However, the correlation between OC presentations and autonomic nervous system (ANS) is still unclear. Furthermore, whether the correlation might be modulated by serotonin is also uncertain. Methods: We recruited eighty-nine healthy subjects. Serotonin transporter (SERT) availability by [123I]ADAM and heart rate variability (HRV) tests were measured. Symptoms checklist-90 was measured for the OC presentations. The interaction between HRV and SERT availability were calculated and the correlation between HRV and OC symptoms were analyzed after stratified SERT level into two groups, split at medium. Results: The interactions were significant in the factors of low frequency (LF), high frequency (HF), and root mean square of successive differences (RMSSD). Furthermore, the significantly negative correlations between OC symptoms and the above HRV indexes existed only in subjects with higher SERT availability. Conclusion: OC symptoms might be correlated with ANS regulations in subjects with higher SERT availability.
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The Interaction of Oxytocin and Social Support, Loneliness, and Cortisol Level in Major Depression
Tsung-Yu Tsai,Huai-Hsuan Tseng,Mei Hung Chi,Hui Hua Chang,Cheng-Kuan Wu,Yen Kuang Yang,Po See Chen 대한정신약물학회 2019 CLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE Vol.17 No.4
Objective: Loneliness is a specific risk factor for depressive symptoms and suicidal behavior. The present study examined whether the serum oxytocin level would interact with social support and buffers loneliness and hypothalamic-pituitary- adrenal (HPA)-axis activity in drug-naïve patients with major depressive disorder (MDD). Methods: Twenty-six patients with MDD (male:female = 3:23; mean age, 45.54 ± 12.97 years) were recruited. The 17-item Hamilton Depression Rating Scale, UCLA Loneliness Scale and self-reported Measurement of Support Function Questionnaire were administered. Serum oxytocin and cortisol levels were assessed using a commercial immunoassay kits. Results: In MDD patients, a negative association was found between degrees of social support and loneliness ( = −0.39, p = 0.04). The interaction between social support and serum oxytocin level was negatively associated with loneliness ( = −0.50, p = 0.017) and serum cortisol level ( = −0.55, p = 0.020) after adjusting for age. Follow-up analyses showed that the association between higher social support and lower loneliness was observed only in the higher-oxytocin group (r = −0.75, p = 0.003) but not in the lower group (r = −0.19, p = 0.53). The significance remained after further adjusting for sex and depression severity. Conclusion: Low oxytocin level is a vulnerability factor for the buffering effect of social support for loneliness and aberrant HPA-axis activity in MDD patients.
KCI
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