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      • Fatigue Analysis of Lower Limb Muscle Group Using Elliptical Machine with Constant Loading

        ( Li-cheng Hsieh ),( Ching-chia Hsieh ) 한국농업기계학회 2018 한국농업기계학회 학술발표논문집 Vol.23 No.1

        The elliptical machine or trainer is one of the most popular sports equipment for cardiorespiratory fitness training. In recent years, it is widely used in the family and the gymnasium in Taiwan. Therefore, it is necessary for further discussion about the movements of the elliptical machine, and various levels of the lower-limb muscular fatigue using the elliptical machine in various strengths. The research collected the electromyography (EMG) signal of lower limb muscles, and used the commercially available software to analyze the possible timing that the fatigue appeared. The research applied this system to analyze the lower-limb muscular fatigue when using the elliptical machine with a constant resistance. It compiled the relevant literature, developed the experimental methods and analyzed the results. The subjects of this research arranged ten young people who used elliptical trainer for the first time. They carried the EMG and pedaled in a nature way. Then, Fourier transform was applied for all collected data, and the median frequency was calculated from 80% of the maximum value of the mild fatigue. The result showed that 60% of subject’s rectus muscle had been fatigued first. As a result, when using the elliptical trainer, it was much easier to use the muscles of the front thigh and get tired. Most of the fatigue occurred from overusing the lower limb muscle. By understanding the biomechanics of the elliptical trainer, it could avoid or reduce the fatigue and injuries during exercise. The system can analyze the fatigue timing as well. The fatigue analysis results would help the elliptical machine users avoid injuries, and increasing the efficiency of elliptical training.

      • SCIESCOPUSKCI등재

        Longevity, tumor, and physical vitality in rats consuming ginsenoside Rg1

        Chao-Chieh Hsieh,Chiung-Yun Chang,Tania Xu Yar Lee,Jinfu Wu,Suchada Saovieng,Yu-Wen Hsieh,Maijian Zhu,Chih-Yang Huang,Chia-Hua Kuo The Korean Society of Ginseng 2023 Journal of Ginseng Research Vol.47 No.2

        Background: Effects of the major ginsenoside Rg1 on mammalian longevity and physical vitality are rarely reported. Purpose: To examine longevity, tumor, and spontaneous locomotor activity in rats consuming Rg1. Methods: A total of 138 Wistar rats were randomized into 2 groups: control (N = 69) and Rg1 (N = 69). Rg1 (0.1 mg/kg per day) were orally supplemented from 6 months of age until natural death. Spontaneous mobility was measured by video-tracking together with body composition (dual energy x-ray absorptiometry) and inflammation markers at 5, 14, 21, and 28 months of age. Results: No significant differences in longevity (control: 706 days; Rg1: 651 days, p = 0.77) and tumor incidence (control: 19%; Rg1: 12%, p = 0.24) were observed between the two groups. Movement distance in the control group declined significantly by ~60% at 21 months of age, together with decreased TNF-α (p = 0.01) and increased IL-10 (p = 0.02). However, the movement distance in the Rg1 group was maintained ~50% above the control groups (p = 0.01) at 21 months of age with greater magnitudes of TNF-α decreases and IL-10 increases. Glucose, insulin, and body composition (bone, muscle and fat percentages) were similar for both groups during the entire observation period. Conclusion: The results of the study suggest a delay age-dependent decline in physical vitality during late life by lifelong Rg1 consumption. This improvement is associated with inflammatory modulation. Significant effects of Rg1 on longevity and tumorigenesis were not observed.

      • SCISCIESCOPUS

        OBSERVATIONAL AND DYNAMICAL CHARACTERIZATION OF MAIN-BELT COMET P/2010 R2 (La Sagra)

        Hsieh, Henry H.,Yang, Bin,Haghighipour, Nader,Novaković,, Bojan,Jedicke, Robert,Wainscoat, Richard J.,Denneau, Larry,Abe, Shinsuke,Chen, Wen-Ping,Fitzsimmons, Alan,Granvik, Mikael,Grav, Tommy,Ip, American Institute of Physics 2012 The Astronomical journal Vol.143 No.5

        <P>We present observations of the recently discovered comet-like main-belt object P/2010 R2 (La Sagra) obtained by Pan-STARRS1 and the Faulkes Telescope-North on Haleakala in Hawaii, the University of Hawaii 2.2 m, Gemini-North, and Keck I telescopes on Mauna Kea, the Danish 1.54 m telescope (operated by the MiNDSTEp consortium) at La Silla, and the Isaac Newton Telescope on La Palma. An antisolar dust tail is observed to be present from 2010 August through 2011 February, while a dust trail aligned with the object's orbit plane is also observed from 2010 December through 2011 August. Assuming typical phase darkening behavior, P/La Sagra is seen to increase in brightness by >1 mag between 2010 August and December, suggesting that dust production is ongoing over this period. These results strongly suggest that the observed activity is cometary in nature (i.e., driven by the sublimation of volatile material), and that P/La Sagra is therefore the most recent main-belt comet to be discovered. We find an approximate absolute magnitude for the nucleus of H<SUB>R</SUB> = 17.9 ± 0.2 mag, corresponding to a nucleus radius of ~0.7 km, assuming an albedo of p = 0.05. Comparing the observed scattering surface areas of the dust coma to that of the nucleus when P/La Sagra was active, we find dust-to-nucleus area ratios of A<SUB>d</SUB>/A<SUB>N</SUB> = 30-60, comparable to those computed for fellow main-belt comets 238P/Read and P/2008 R1 (Garradd), and one to two orders of magnitude larger than for two other main-belt comets (133P/Elst-Pizarro and 176P/LINEAR). Using optical spectroscopy to search for CN emission, we do not detect any conclusive evidence of sublimation products (i.e., gas emission), finding an upper limit CN production rate of Q<SUB>CN</SUB> < 6 × 10<SUP>23</SUP> mol s<SUP>–1</SUP>, from which we infer an H<SUB>2</SUB>O production rate of <img SRC='http://ej.iop.org/images/1538-3881/143/5/104/aj423523ieqn1.gif' ALIGN='MIDDLE' ALT='$Q_{\rm H_2O}\,{<}\,10^{26}$'/> mol s<SUP>–1</SUP>. Numerical simulations indicate that P/La Sagra is dynamically stable for >100 Myr, suggesting that it is likely native to its current location and that its composition is likely representative of other objects in the same region of the main belt, though the relatively close proximity of the 13:6 mean-motion resonance with Jupiter and the (3,–2,–1) three-body mean-motion resonance with Jupiter and Saturn mean that dynamical instability on larger timescales cannot be ruled out.</P>

      • KCI등재

        THE ORBITAL EPHEMERIS OF THE PARTIAL ECLIPSING X-ray BINARY X1822-371

        HSIEH, HUNG-EN,CHOU, YI,HU, CHIN-PING,YANG, TING-CHANG,SU, YI-HAO,LIN, CHING-PING,CHUANG, PO-SHENG,LIAO, NAI-HUI The Korean Astronomical Society 2015 天文學論叢 Vol.30 No.2

        X1822-371 is a low mass X-ray binary with an accretion disk corona exhibiting partial eclipses and pulsations in the X-ray band. We update its orbital ephemeris by combining new RXTE observations and historical records, with a total time span of 34 years. There were 11 RXTE observations in 2011 but the eclipsing profile can be seen in only 4 of them. The eclipsing center times were obtained by fitting the profile with the same model as previous studies. Combined with the eclipsing center times reported by Iaria et al. (2011), the O-C analysis was processed. A quadratic model was applied to fit the O-C results and produced a mean orbital period derivative of $\dot{P}_{orb}=1.339(25){\times}10^{-10}s/s$, which is slightly smaller than previous records. In addition to the orbital modulation from the orbital profile, we also present our preliminary results for measuring the orbital parameters using the orbital Doppler effect from the pulsation of the neutron star in X1822-371. The updated orbital parameters from eclipsing profiles will be further compared with the ones from pulsar timing.

      • Tumors Involving Skin, Soft Tissue and Skeletal Muscle: Benign, Primary Malignant or Metastatic?

        Hsieh, Chi-Ying,Tsai, Huang-Wen,Chang, Chih-Chun,Lin, Tsuo-Wu,Chang, Ke-Chung,Chen, Yo-Shen Asian Pacific Journal of Cancer Prevention 2015 Asian Pacific journal of cancer prevention Vol.16 No.15

        Background: Metastatic cancer with invasion of skin, soft tissue and skeletal muscle is not common. Examples presenting as soft tissue masses could sometimes lead to misdiagnosis with delayed or inappropriate management. The purpose of current study was to investigate clinical characteristics in the involvement of metastatic cancer. Materials and Methods: A total of 1,097 patients complaining of skin or soft tissue masses and/or lesions were retrospectively reviewed from January 2012 to June 2013. Tumors involving skin, soft tissue and skeletal muscle of head and neck, chest wall, abdominal wall, pelvic region, back, upper and lower extremities were included in the study. Results: Fifty-seven (5.2%) patients were recognized as having malignancies on histopathological examination. The most common involvement of malignancy was basal cell carcinoma, followed by cutaneous squamous cell carcinoma, sarcoma and melanoma. The most common anatomical location in skin and soft tissue malignancies was head and neck (52.6% of the malignancies). Four (0.36%) of the malignant group were identified as metastatic cancer with the primary cancer source from lung, liver and tonsil and the most common site was upper extremities. One of them unexpectedly expired during the operation of metastatic tumor excision at the scalp. Conclusions: Discrimination between benign and malignant soft tissue tumors is crucial. Performance of imaging study could assist in the differential diagnosis and the pre-operative risk evaluation of metastatic tumors involving skin, soft tissue and skeletal muscle.

      • Delivery the Chemotherapeutic Drug through Redox Sensitive Polymeric Nano-carrier for Cancer Treatment

        Hsieh-Chih Tsai 한국고분자학회 2021 한국고분자학회 학술대회 연구논문 초록집 Vol.46 No.2

        Smart drug delivery systems have showed great potential for the disease treatment that can be stimulated by the changes in the environmental parameter. Among all the smart carrier, biocompatible amphiphilic block copolymers have been considered as the most promising bio-materials to delivery of anticancer drug due to the formation core-shell nanoparticles protect the above agents. The self-assembled nanostructure exhibited several advantage when delivery the therapeutic drug, such as improve the solubility and stability of drug before transportation to targeting organs. However, the non-select drug release from the amphiphilic copolymer limit their application in the treatment of cancer disease. Thus, the introducing of stimuli sensitive and easily cleavable groups in the polymer chain during the synthesis of materials is essential to achieve rapid and relatively completely drug release from the carrier in the cancer environment. Therefore, we have synthesized two kind of Di-selenide contained copolymer system (Bi(mPEG-SeSe)-b-(PCL) and Bi(mPEG-b-PLGA)-Se2) and evaluation their drug released mechanism of above two approach. Di-selenide containing block copolymer exhibited the selective drug release only in cancer cells, which can be utilized as targeting strategy for delivery anticancer drug.

      • A Project for Dealing with the Missing Character Problem

        Hsieh, C.C.,Wittern, Christian,Lehman, John 동국대학교 전자불전연구소 2001 전자불전 Vol.3 No.-

        The project described in this paper takes advantage of the 7 year experience of the Academia Sinica Institute of Information Science Document Processing Laboratory in studying the missing character problem. It is intended to develop a packaging and processing system which is compatible with international standards for use in an internet or Windows environment. The initial design constraints were to use XML markup as part of a system to allow the viewing and processing of documents containing missing characters by any personal computer capable of running Windows 98, and using standard software such as Microsoft Word. It requires no modification of the user’s system or software, and provides facilities for sharing data between users. The project was funded by a grant from the Republic of China (Taiwan) Ministry of Education, and is expected to be further developed to run on a larger variety of systems.

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