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Jia-Kang Wang,Shu-jun Guo,Bao-qing Tian,Chnag-jun Nie,Hai-long Wang,Jia-lang Wang,An Hong,Xiao-jia Chen 대한독성 유전단백체 학회 2017 Molecular & cellular toxicology Vol.13 No.4
Fibroblast growth factors(FGFs) and their receptors (FGFRs) modulate a wide range of biological functions, especially tumor genesis. The aim of this study was to investigate the possible association of FGFR expression with the susceptibility of digestive system and reproductive system cancers in Chinese population. In total, 343 patients with digestive or reproductive system cancers were enrolled in this study. The expression levels of four highly-conserved FGFRs including FGFR1, FGFR2, FGFR3 and FGFR4 were measured by immunohistochemistry (IHC). The expression levels of FGFRs were compared between carcinoma and para-carcinoma tissues. FGFR1 expression significantly differed between carcinoma and para-carcinoma tissues in colon and gastric cancers. FGFR2 expression significantly differed between carcinoma and para-carcinoma tissues in esophageal cancer. FGFR3 expression was significantly different between carcinoma and para-carcinoma tissues in liver and gastric cancers. FGFR2 showed the highest expression probability in all the selected cancers and FGFR4 showed the lowest expression probability. FGFR1 and FGFR3 showed comparable moderate expression probabilities. Our findings have demonstrated significant differences regarding FGFR expression levels between carcinoma and para-carcinoma cells in digestive or reproductive system cancer patients. The data also implicated that FGFR2 and FGFR4 could serve as two prominent factors closely related to the susceptibility of digestive and reproductive system cancers.
Regulation Roles of MICA and NKG2D in Human Renal Cancer Cells
Jia, Hong-Ying,Liu, Jun-Li,Yuan, Ming-Zhen,Zhou, Cheng-Jun,Sun, Wen-Dong,Zhao, Jing-Jie,Wang, Jue,Liu, Ling,Luan, Yun Asian Pacific Journal of Cancer Prevention 2015 Asian Pacific journal of cancer prevention Vol.16 No.9
Objective: Our aim was to investigation the roles of MHC class I chain-related gene A(MICA) and natural killer cell group 2D(NKG2D) in human renal cancer cells. Materials and Methods: The expression of membrane MICA (mMICA) on renal cells and NKG2D on NK cells were detected by flow cytometry (FCM); the content of sMICA were detected by enzyme linked immunosorbent assay (ELISA) and the distribution of mMICA on renal tumor tissues by immunohistochemistry; the interaction between MICA and NKG2D was observed by antibody closed method. Results: Our results showed that the expression of mMICA in renal cancer tissues was significantly higher than in controls, where the soluble MICA was not expressed. Cytotoxic activity of NK cells was significantly reduced after exposure to NKG2D and MICA antibodies (P<0.05), and serum containing sMICA can obviously lower the function of NKG2D (P<0.05). Conclusions: The interaction of mMICA and NKG2D play important roles in mediation of cytotoxicity of NK cells in RCC. On the other hand, sMICA may mediate tumor immune escape through down- regulated NKG2D expression.
Deuterium Clusters Fusion Induced by the Intense Femtosecond Laser Pulse
Hong-Jie, Liu,Zhi-Jian, Zheng,Yu-Qiu, Gu,Bao-Han, Zhang,Yong-Joo, Rhee,Sung-Mo, Nam,Jae-Min, Han,Yong-Woo, Rhee,Kwon-Hae, Yea,Jia-Bin, Chen,Hong-Bin, Wang,Chun-Ye, Jiao,Ying-Ling, He,Tian-Shu, Wen,Xia ALLERTON PRESS INC 2007 CHINESE PHYSICS LETTERS Vol.24 No.2
<P>Neutrons (2.45 MeV) from deuterium cluster fusion induced by the intense femtosecond (30 fs) laser pulse are experimentally demonstrated. The average neutron yield 10<SUP>3</SUP> per shot is obtained. It is found that the yield slightly increases with the increasing laser spot size. No neutron can be observed when the laser intensity I < 4.3×10<SUP>15</SUP> W/cm<SUP>2</SUP>.</P>
Nonlinearity of Shear Response of Unidirectional Laminates under Combined Loading
Hongli Jia(지아홍리),Hyun-Ik Yang(양현익) 한국고분자학회 2018 폴리머 Vol.42 No.6
본 논문에서는 보완된 변형 에너지 밀도 함수를 기반으로 하여 평면내 비선형 응력-변형률 곡선 모델을 제시한다. 다방향의 적측판에 전단방향과 축방향의 응력이 조합되어 작용할 때의 전단방향의 응답을 예측하였으며, 실험값과 비교하여 제시 모델의 정확성을 검증하였다. 이 과정에서 compliance 상수는 기존 축방향의 응력에 대한 측정값과 일치하도록 결정되었다. 마지막으로 제시된 모델을 이용한 E-glass/vinylester의 전단 응력-변형률 거동은 모든 축외 각도에 대하여 실험 곡선과 일치하며, boron/epoxy와 T800H/3633 적층판의 전단 거동은 15도를 제외한 30도, 45도, 60도의 축외 각도(off-axis angle)에 대하여 실험값과 일치한다. 이는 작은 적층 각도의 변화에도 종방향의 탄성계수는 다른 탄성계수에 비하여 매우 높기 때문이다. We present the prediction of nonlinear in-plane shear stress strain curves based on complementary strain energy density function. When the [θ˚] unidirectional laminates are subjected to a combination of shear stresses and axial stresses, the predicted shear responses of laminates are compared with measured experimental data for verifying this accuracy of this model. In this process, the compliance constants are determined to match the measured test results in terms of the influence of on-axis axial stress. Finally, it is shown that the predicted shear stress strain behavior of E-glass/vinylester concurs with experimental curves for all off-axis angles, while shear behavior predictions of boron/epoxy and T800H/3633 laminates agree with experimental results for 30˚ 45˚ 60˚ off-axis angles laminates except 15˚ off-axis angle laminates. This is because the elastic longitudinal modulus is still significantly higher than the other modulus even for a small off axis angle.
Jia-Hong Zhang,Chia-Yen Chen 한국정보통신학회 2014 2016 INTERNATIONAL CONFERENCE Vol.6 No.1
This paper proposes a method for improving the egomotion determination by using latent semantic indexing for feature description and enhancing feature matching via an adaptive procedure. Input binocular stereo images are processed by the SURF detector, the descriptions are analyzed semantically with SVD and new feature descriptors are generated. Restrictions of matching pairs are established based on the epipolar geometry, which are then adaptively adjusted between successive image pairs. Four types of experiments are conducted and experiment results demonstrated the effectiveness of the proposed approach in providing smaller numbers of initial match candidates with higher probability of correct matches.
High Expression of MICA in Human Kidney Cancer Tissue and Renal Cell Carcinoma Lines
Jia, Hong-Ying,Liu, Jun-Li,Zhou, Cheng-Jun,Kong, Feng,Yuan, Ming-Zhen,Sun, Wen-Dong,Wang, Jue,Liu, Ling,Zhao, Jing-Jie,Luan, Yun Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.4
The overall incidence and mortality of renal cell carcinoma (RCC), the most common kidney cancer, are steadily increasing for reasons that are not fully explained. Our aim was to explore the expression of membrane MHC class I chain-related gene A (mMICA) in human RCC cell lines and tissue specimens, and to determine expression of soluble MICA (sMICA) in serum of patients with renal cell carcinoma, we used flow cytometry (FCM) and immunohistochemistry as well as an enzyme linked immunosorbent assay (ELISA). The results showed that percentage of mMICA expression was significantly increased in human kidney cancer tissues and RCC cell lines (786-O and Ketr-3) than that in healthy adults and human embryonic kidney 293 (HEK293) cell line individuality (P<0.05). sMICA content in healthy adults was negative, but in renal cancer patients was significantly elevated (P<0.05). Our research showed that high expression of MICA in human kidney cancer, this results show that MICA might serve as potential tumor-associated antigen (TAA) in RCC.
Hong Pan, Jia,In Lee, Wan Royal Society of Chemistry 2005 NEW JOURNAL OF CHEMISTRY Vol.29 No.6
<P>Highly organized mesoporous titania and silica thin films were synthesized using a triblock copolymer-templated sol-gel method <I>via</I> an evaporation-induced self-assembly (EISA) process. For the first time, we have found that the mesophase of these metal oxides can be selectively controlled by varying the spin-coating conditions. With spin-coating at a low speed, such as 600 rpm, cubic mesoporous TiO<SUB>2</SUB> or SiO<SUB>2</SUB> thin films are obtained, whereas 2D hexagonal mesoporous thin films are formed at a high spin-coating speed of around 2000 rpm for 20 s. On the other hand, a mixture of hexagonal and cubic phase is formed for films prepared at an intermediate spinning speed of 1000 rpm for 10 s. The fabricated mesoporous thin films, characterized by XRD, TEM, and UV-visible spectroscopy, show that the mesopore structures are highly ordered, without any cracks, and thermally stable (up to 400 °C). The hexagonal and cubic mesoporous TiO<SUB>2</SUB> films of 300–320 nm thickness have about 95% transparency and exhibit a ultra-uniform surfaces. We believe that the evaporation rate of volatile components in the coated film is qualitatively proportional to the speed of spin-coating, and this determines the mesophase of the resultant films.</P> <P>Graphic Abstract</P><P>Highly ordered cubic and hexagonal mesoporous TiO<SUB>2</SUB> and SiO<SUB>2</SUB> thin films can be selectively obtained by varying the spin-coating conditions in the evaporation-induced self-assembly process. <IMG SRC='http://pubs.rsc.org/services/images/RSCpubs.ePlatform.Service.FreeContent.ImageService.svc/ImageService/image/GA?id=b417310d'> </P>
Hongli Jia,양현익,김창완,Hun Bong Lim 대한기계학회 2020 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.34 No.4
In present study, laminates with the type of [±θ°] S and [0° 2 /±θ°] S are investigated in order to clearly show the effect of material shear nonlinearity, and then theoretical predictions are compared with experimental data. In the whole process of generating failure envelopes, secant shear modulus instead of initial shear modulus is used for accurate shear stress-strain relation. The modulus values are recalculated every time when the combining load is changed. Final failure envelopes are then compared between numerical models. It is found that the variation in the size of safe regions from nonlinear analysis is closely related to the way of combing load and fiber directions. So in the process of improving failure theories or in the applications of failure theories, the effect of material nonlinearity can be considered appropriately.