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- 저자 : Heping Peng (검색결과 2 건)
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Heping Peng,Zhuoqun Peng 한국CDE학회 2020 Journal of computational design and engineering Vol.7 No.2
This paper focuses on exploring an iterative method of statistical tolerance design to guide designers to select tolerances more economically and effectively. After having identified the assembly functional requirement (FR) and the functional elements (FEs) of corresponding tolerance chain, the expression of a unified Jacobian–Torsor model can be derived. Monte Carlo simulation is employed to generate random variables simulating the variations of small displacement torsor associated with the FE pairs with all the generated random values being within the intervals constrained by the corresponding tolerance zones. Then, the real multiplication operations are repeatedly executed to this model, a large number of real torsor component values of FR will be obtained and we can perform statistical analysis for these simulated data to get the statistical limits of the assembly FR in the desired direction. The tolerances of critical FEs may need to be adjusted to satisfy the assembly FR imposed by the designer, and the percentage contribution of each FE to the assembly FR can help determine these critical tolerances that need to be tightened or loosened. Once the calculated FR is in close agreement with the imposed FR, the iterative process can be stopped, and the statistical tolerance redesign is achieved. The effectiveness of the proposed method is illustrated with a case study. Compared with the deterministic tolerancing method, the results show that the proposed method is more economical and that can relax significantly the precision required, manufacturing and inspection costs can then be reduced considerably.
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Xiaofeng Jiang,De Chen,Guangyang Xiang,Yezeng Wang,Lei Zhang,Xuewei Yang,Liangqi Cao,Heping Peng,Ping Xue 한국분자세포생물학회 2012 Molecules and cells Vol.33 No.6
MicroRNAs (miRNAs) are regulatory small non-coding RNAs that can regulate gene expression by binding to gene elements, such as the gene promotor 5UTR, mainly in the 3UTR of mRNA. One miRNA targets many mRNAs, which can be regulated by many miRNAs, leading to a complex metabolic network. In our study, we found that the expression level of miR-590-5p is higher in the human hepatocellular carcinoma cell line HepG2 than in the normal hepatocellular cell line L02. Downregulation of miR-590-5p inhibited proliferation and invasion of hepatocellular carcinoma cells (HCCs). We also showed that expression of TGF-beta RII, which has been regarded as a regulator of tumor proliferation, invasion, and migration in hepatocellular carcinoma, is regulated by miRNA-590-5p. In addition, miR-590-5p downregulated the expression of TGF- beta RII by targeting the 3UTR of mRNA. We also found that downregulation of miR-590-5p was associated with an elevation of TGF-beta RII and inhibition of proliferation and invasion in HepG2 cells. Furthermore, overex-pression of miR-590-5p was associated with upregulation of TGF-beta RII and could promote proliferation and invasion in L02 cells. In conclusion, we determined that TGF-beta RII is a novel target of miRNA-590-5p. Thus, the role of TGF-beta RII in regulating proliferation and invasion of human HCCs is controlled by miR-590-5p. In other words, miR-590-5p promotes proliferation and invasion in human HCCs by directly targeting TGF-beta RII.
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