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RISS 인기검색어
- 검색키워드
- 저자 : Haque, Mohammad R. (검색결과 479 건)
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Shifting Cultivation Effects on Soil Environment in Upland Watershed of Bangladesh
Haque, S.M. Sirajul,Gupta, Sanatan Das,Miah, Sohag Institute of Forest Science 2014 Journal of Forest Science Vol.30 No.2
This research reports the effects of shifting cultivation on soil environment collecting samples from 0-5 cm soil depth from five locations viz. at Burburichhara, Maichchari, Longadu, Sukurchhari and Muralipara in Rangamati district of Chittagong Hill Tracts (CHTs). Soil analyses showed that fungal and bacterial population, microbial respiration and active microbial biomass, maximum water holding capacity, conductivity and moisture contents were significantly (at least $p{\leq}0.05$) lower in shifting cultivated soil compared to adjacent mixed tree plantations at all the sites. On an average in soils of 5 different shifting cultivated lands fungal population was $1.33{\times}10^5$ CFU/g dry soil and bacterial population $1.80{\times}10^7$ CFU/g dry soil and in mixed plantations fungal population was $1.70{\times}10^5$ and bacterial population $2.51{\times}10^7$ CFU/g dry soil. Organic matter and exchangeable Ca and Mg contents were significantly (at least $p{\leq}0.05$) lower and bulk density significantly (at least $p{\leq}0.05$) higher in shifting cultivated land in most of the locations compared to adjacent mixed tree plantations. Ratios of microbial respiration and organic carbon as well as active microbial biomass and organic carbon were distinctly lower and pH higher at 3 locations in shifting cultivated soils compared to mixed plantations. Findings of various soil properties, therefore, suggest that shifting cultivation has deteriorating effects on soil environment.
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Haque, Md. Mamunul,Kim, Dohee,Yu, Young Hyun,Lim, Sungsu,Kim, Dong Jin,Chang, Young-Tae,Ha, Hyung-Ho,Kim, Yun Kyung Informa UK Ltd. 2014 Amyloid Vol.21 No.3
<P>Abnormal tau aggregates are presumed to be neurotoxic and are an important therapeutic target for multiple neurodegenerative disorders including Alzheimer’s disease. Growing evidence has shown that tau intermolecular disulfide cross-linking is critical in generating tau oligomers that serve as a building block for higher-order aggregates. Here we report that a small molecule inhibitor prevents tau aggregation by blocking the generation of disulfide cross-linked tau oligomers. Among the compounds tested, a rosamine derivative bearing mild thiol reactivity selectively labeled tau and effectively inhibited oligomerization and fibrillization processes <I>in vitro</I>. Our data suggest that controlling tau oxidation status could be a new therapeutic strategy for prevention of abnormal tau aggregation.</P>
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Haque, Enamul,Khan, Nazmul Abedin,Kim, Chang Min,Jhung, Sung Hwa American Chemical Society 2011 Crystal Growth & Design Vol.11 No.10
<P>Several porous materials such as metal–organic frameworks (MOFs) and aluminophosphates have been synthesized with microwave and conventional electric heating in various temperatures and times to investigate the quantitative acceleration in the synthesis of porous materials by microwaves. From the analysis of the acceleration under microwave heating with the Eyring equation, it can be understood that, irrespective of the type of porous materials, the acceleration by microwaves is mainly due to decreased activation free energy (Δ<I>G</I><SUP>⧧</SUP>) even though the activation energy (<I>E</I><SUB>a</SUB>) and activation enthalpy (Δ<I>H</I><SUP>⧧</SUP>) are increased. The decreased activation free energy is mainly due to the high activation entropy (Δ<I>S</I><SUP>⧧</SUP>) of microwave synthesis compared with the entropy of conventional electric synthesis. Accelerated synthesis with microwaves may be explained with changes of relative energies of intermediates for high activation entropy.</P><P>The accelerated synthesis of porous materials under microwave is mainly due to the decreased activation free energy even though the enthalpy and activation energy are increased.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/cgdefu/2011/cgdefu.2011.11.issue-10/cg200594e/production/images/medium/cg-2011-00594e_0008.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/cg200594e'>ACS Electronic Supporting Info</A></P>
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Haque, M.R.,Kim, J.,Park, H.,Lee, H.S.,Lee, K.W.,Al-Hilal, T.A.,Jeong, J.H.,Ahn, C.H.,Lee, D.S.,Kim, S.J.,Byun, Y. Elsevier Science Publishers 2017 Journal of controlled release Vol.258 No.-
<P>Islet transplantation is as effective as but also less immunogenic than pancreas transplantation for the treatment of type 1 diabetes mellitus. However, as the complete elimination of immunogenicity still remains a major obstacle in islet transplantation, layer-by-layer encapsulation (LbL) of pancreatic islets using biocompatible polymers offers a rational approach to reducing host immune response towards transplanted islets. We investigated the effect of LbL of non-human primate (NHP) islets on reducing immunogenicity as a preclinical model since NHPs have close phylogenetic and immunological relationship with humans. LbL with three-layers of polyethylene glycol (PEG) molecules (SH-6-arm-PEG-NHS, 6-arm-PEG-catechol and linear PEG-SH) showed a uniform nano-shielding on islets without the loss of viability or function of islets. An immunosuppressive drug protocol was also combined to improve the survival rate of the transplanted islets in vivo. A xenorecipient (C57BL/6 mice) of LbL islet transplanted along with our immunosuppressive drug protocol showed 100% survival rate for 150 days after transplantation. On the other hand, naked islet recipients showed poor survival time of 5.5 +/- 1.4 days without drugs and 77.5 +/- 42 days with the drug protocol. Immunohistochemistry of the transplanted grafts and serum cytokine concentration demonstrated less immunogenicity in the LbL islet transplanted recipients compared with the naked islet ones.</P>
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Haque, Md.A.,Lee, J.H.,Cho, K.M. Butterworths ; Taylor Francis ; Elsevier Science 2015 FOOD CONTROL Vol.56 No.-
The diversity of bacterial endophytes associated with Chinese cabbage (CC) leaves from two cultivation areas in Korea, namely, Seosang-gun (SS) and Haenam-gun (HN), and from a laboratory transgenic plant (TP) was investigated. A total of 5.76 log CFU/g isolates were identified from the interior leaves of the three cultivars of CC, which were grouped into 5.08, 5.36, and 5.34 log CFU/g from SS, HN, and TP samples, respectively. Phylogenetic analysis based on the 16S rRNA sequences indicated that the isolates belonged to four major phylogenetic groups: high-G + C Gram-positive bacteria (HGCGPB), low-G + C Gram-positive bacteria (LGCGPB), Proteobacteria, and Bacteroidetes. The most predominant group of species in the leaves of the SS, HN and TP CC cultivars were LGCGPB (50%), LGCGPB (65.2%), and HGCGPB (43%), respectively. A total of 23 bacterial genera were identified from the three cultivars of Chinese cabbage. Most extracellular hydrolytic enzyme-producing colonies among the isolates belong to the genus Bacillus those were predominant in the HN cultivars. In addition, some isolates especially Bacillus sp. (TPL08), Bacillus subtilis (SSL16, HNL10) exhibited potential activity as biocontrol agents against food-borne pathogenic bacteria and phytopathogenic fungi tested in this study. This study first revealed the endophytic bacterial communities in leaves of Chinese cabbage (main ingredients of kimchi) grown in Korea.
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Targeting the microglial NLRP3 inflammasome and its role in Parkinson's disease
Haque, Md. Ezazul,Akther, Mahbuba,Jakaria, Md.,Kim, In‐,Su,Azam, Shofiul,Choi, Dong‐,Kug John WileySons, Inc. 2020 Movement disorders Vol.35 No.1
<P><B>Abstract</B></P><P>Excessive activation of microglia and subsequent release of proinflammatory cytokines play a crucial role in neuroinflammation and neurodegeneration in Parkinson's disease (PD). Components of the nucleotide‐binding oligomerization domain and leucine‐rich‐repeat‐ and pyrin‐domain‐containing 3 inflammasome complex, leucine‐rich‐repeat‐ and pyrin‐domain‐containing 3, caspase‐1, and apoptosis‐associated speck‐like protein containing a CARD, are highly expressed in activated microglia in PD patient brains. Findings suggest that neurotoxins, aggregation of α‐synuclein, mitochondrial reactive oxygen species, and disrupted mitophagy are the key regulators of microglial leucine‐rich‐repeat‐ and pyrin‐domain‐containing 3 inflammasome activation and release of interleukin‐1β and interleukin‐18 caspase‐1‐mediated pyroptotic cell death in the substantia nigra of the brain. Although this evidence suggests the leucine‐rich‐repeat‐ and pyrin‐domain‐containing 3 inflammasome may be a potential drug target for treatment of PD, the exact mechanism of how the microglia sense these stimuli and initiate leucine‐rich‐repeat‐ and pyrin‐domain‐containing 3 inflammasome signaling is unknown. Here, the molecular mechanism and regulation of microglial leucine‐rich‐repeat‐ and pyrin‐domain‐containing 3 inflammasome activation and its role in the pathogenesis of PD are discussed. Moreover, the potential of both endogenous and synthetic leucine‐rich‐repeat‐ and pyrin‐domain‐containing 3 inflammasome modulators, long noncoding RNA, microRNA to develop novel therapeutics to treat PD is presented. Overall, we recommend that the microglial leucine‐rich‐repeat‐ and pyrin‐domain‐containing 3 inflammasome can be a potential target for PD treatment. © 2019 International Parkinson and Movement Disorder Society</P>
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Haque, Md.M.,Kim, G.W.,Kim, P.J.,Kim, S.Y. Elsevier Scientific Pub. Co 2016 Field crops research Vol.193 No.-
<P>Midseason drainage is regarded as a key practice to suppress methane (CH4) emission from paddy soil during rice cultivation, but it can increase carbon dioxide (CO2) and nitrous oxide (N2O) emissions. However, the influences of midseason drainage practice on the net global warming potential (GWP) and greenhouse gas intensity (GHGI) of rice cropping systems is not well documented in the East monsoon region. In this field study, the effect of a 30-day midseason drainage practice from the 28th day after transplanting (DAT) to the 57th DAT on the three major greenhouse gas (GHG) fluxes and yield properties were compared with those of a continuous flooding system during rice cultivation in 2011 and 2012. The impact of midseason drainage on changing three GHG emissions was compared using the GWP value and GHG intensity (GHGI). Midseason drainage significantly reduced the net GWP scale by 46-50% of the continuous flooding, mainly due to 50-53% reduction of seasonal CH4 fluxes. Midseason drainage significantly increased N2O flux by 20-37% over the conventional flooding, but the influence of N2O emission increase on the net GWP scale was negligible. Midseason drainage significantly decreased soil C sequestration capacity by around 60% of continuous flooding, and then increased net GWP by 0.25-0.32 Mg CO2-eq. ha(-1) during rice cultivation. There was no significant difference of rice yield between two irrigation systems, and then midseason drainage can reduce GHGI by 50-56% of the continuous flooding. In conclusion, the midseason drainage practice during rice cultivation could be very useful soil management strategy to reduce GHG emission impact from lowland rice fields without impacting rice productivity. (C) 2016 Elsevier B.V. All rights reserved.</P>
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