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      • <i>Commiphora molmol</i> Modulates Glutamate-Nitric Oxide-cGMP and Nrf2/ARE/HO-1 Pathways and Attenuates Oxidative Stress and Hematological Alterations in Hyperammonemic Rats

        Mahmoud, Ayman M.,Alqahtani, Sultan,Othman, Sarah I.,Germoush, Mousa O.,Hussein, Omnia E.,Al-Basher, Gadh,Khim, Jong Seong,Al-Qaraawi, Maha A.,Al-Harbi, Hanan M.,Fadel, Abdulmannan,Allam, Ahmed A. Hindawi 2017 Oxidative medicine and cellular longevity Vol.2017 No.-

        <P>Hyperammonemia is a serious complication of liver disease and may lead to encephalopathy and death. This study investigated the effects of <I>Commiphora molmol</I> resin on oxidative stress, inflammation, and hematological alterations in ammonium chloride- (NH<SUB>4</SUB>Cl-) induced hyperammonemic rats, with an emphasis on the glutamate-NO-cGMP and Nrf2/ARE/HO-1 signaling pathways. Rats received NH<SUB>4</SUB>Cl and <I>C. molmol</I> for 8 weeks. NH<SUB>4</SUB>Cl-induced rats showed significant increase in blood ammonia, liver function markers, and tumor necrosis factor-alpha (TNF-<I>α</I>). Concurrent supplementation of <I>C. molmol</I> significantly decreased circulating ammonia, liver function markers, and TNF-<I>α</I> in hyperammonemic rats. <I>C. molmol</I> suppressed lipid peroxidation and nitric oxide and enhanced the antioxidant defenses in the liver, kidney, and cerebrum of hyperammonemic rats. <I>C. molmol</I> significantly upregulated Nrf2 and HO-1 and decreased glutamine and nitric oxide synthase, soluble guanylate cyclase, and Na<SUP>+</SUP>/K<SUP>+</SUP>-ATPase expression in the cerebrum of NH<SUB>4</SUB>Cl-induced hyperammonemic rats. Hyperammonemia was also associated with hematological and coagulation system alterations. These alterations were reversed by <I>C. molmol</I>. Our findings demonstrated that <I>C. molmol</I> attenuates ammonia-induced liver injury, oxidative stress, inflammation, and hematological alterations. This study points to the modulatory effect of <I>C. molmol</I> on glutamate-NO-cGMP and Nrf2/ARE/HO-1 pathways in hyperammonemia. Therefore, <I>C. molmol</I> might be a promising protective agent against hyperammonemia.</P>

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        Enhancing the Opacity of the Modified Natural Thickening Agent with Different Metal Oxides for Covering Dark Dyed Fabrics

        Fedaa Saad,Mohamed M. Mosaad,Hanan A. Othman,Amina L. Mohamed,Ahmed G. Hassabo 한국섬유공학회 2022 Fibers and polymers Vol.23 No.9

        Most natural thickeners do not have a full coverage degree when printing on dark dyed fabrics (brown/navy/black). Therefore, some materials are added to improve their coverage. It is common practice that printing is done on dyed orundyed fabrics. The dyed fabrics are of different shades, so the printing process faces a problem, as most of the naturalthickeners do not have full coverage, especially those extracted from aloe vera and flax seeds when printing on fabrics dyedwith dark colors. Therefore, in this study the effect of adding zinc oxide and titanium oxide to the printing paste was studied. The result confirmed that, adding metal salts to printing paste using aloe vera gel or flaxseeds gum as thickener increases thewhiteness index of these pastes as well as the printed fabric. In addition, using light dye in these printing paste provides goodcovering of dark color with good appearance of the new light color used. Furthermore, the mechanical and physicalcharacteristics of printed textiles with various thickeners and metal oxide (14 %) have been evaluated and provide improvingboth tensile strength and elongation at break and had no effect on the angle of crease recovery of printed textiles across allprinting paste formulations.

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