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Unghui Kim,Haeri Na,Seungmo Yeon,Sajid Iqbal,Jong-Il Yun 한국방사성폐기물학회 2023 한국방사성폐기물학회 학술논문요약집 Vol.21 No.2
The need for the development of sustainable, efficient, and green radioactive waste disposal methods is emerging with the saturation of spent nuclear waste storage facilities in the Republic of Korea. Conventional radioactive waste management methods like using cement or glass have drawbacks such as high porosity, less chemical stability, high energy consumption, carbon dioxide production, and the generation of secondary wastes, etc. To address this gigantic issue of the planet, we have designed a study to explore the potential of alternative materials having easy processability, low carbon emissions and more chemical stability such as ceramic (hydroxyapatite, HAP) and alkali-activated materials (geopolymers, GP) to capture the simulated radioactive cobalt ions from the contaminated water and directly solidify them at low temperatures. Physical and mechanical properties of HAP alone and 15wt% GP incorporated HAP (HAP-GP- 15) composite were studied and compared. The surface of both materials was fully sorbed with an excess amount of Co(II) ions in the aqueous system. Co(II) sorbed powders were separated from aqueous media using a centrifuge machine operating at 5,000 RPM for 10 minutes and dried at 100°C for 8 hours. The dried powders were then placed in stainless steel molds, and shaped into cylindrical pellets using a uniaxial press at a pressure of 1 metric ton for 1 minute. The pellets were sintered at 1,100°C for 2 hours at a heating rate of 10°C/min. Following this, the water absorption, density, porosity, and compressive strength of the polished pellets were measured using standard methods. Results showed that HAP has a greater potential for decontamination and solidification of Co(II) due to its higher density (2.65 g/cm3 > 1.90 g/cm3), less open porosity (16.2±2.9% < 42.4 ±0.9%) and high compressive strength (82.1±10.2 MPa > 6.9±0.8 MPa) values at 1,100°C compared to that of HAP-GP-15. Nevertheless, further study with different constituent ratio of HAP and GP at various temperatures is required to fully optimize the HAP-GP matrix for waste solidifications.
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YoungJong Kim,JinKyung Park,WonSub Kang,SuKang Kim,Changsu Han,HaeRi Na,HaeJeong Park,JongWoo Kim,YoungYoul Kim,MoonHo Park,JongWoo Paik 대한신경정신의학회 2017 PSYCHIATRY INVESTIGATION Vol.14 No.1
Objective-Mitochondrial dysfunction is a prominent and early feature of Alzheimer’s disease (AD). The morphologic changes observed in the AD brain could be caused by a failure of mitochondrial fusion mechanisms. The aim of this study was to investigate whether genetic polymorphisms of two genes involved in mitochondrial fusion mechanisms, optic atrophy 1 (OPA1) and mitofusin 2 (MFN2), were associated with AD in the Korean population by analyzing genotypes and allele frequencies. Methods-One coding single nucleotide polymorphism (SNP) in the MFN2, rs1042837, and two coding SNPs in the OPA1, rs7624750 and rs9851685, were compared between 165 patients with AD (83 men and 82 women, mean age 72.3±4.41) and 186 healthy control subjects (82 men and 104 women, mean age 76.5±5.98). Results-Among these three SNPs, rs1042837 showed statistically significant differences in allele frequency, and genotype frequency in the co-dominant 1 model and in the dominant model. Conclusion-These results suggest that the rs1042837 polymorphism in MFN2 may be involved in the pathogenesis of AD.
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