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( Ahmed Zaghloul Fouad ),( Iman Riad M. Abdel-aal ),( Mohamed Rabie Mohamed Ali Gadelrab ),( Hany Mohammed El-hadi Shoukat Mohammed ) 대한통증학회 2021 The Korean Journal of Pain Vol.34 No.2
Background: Inguinal hernia repair is one of the most commonly performed surgical procedures. Regional blocks might provide excellent analgesia and reduce complications in the postoperative period. We aimed to compare the postoperative analgesic effect of the ultrasound-guided transversalis fascia (TF) plane block versus the transmuscular quadratus lumborum (QL) block in patients undergoing unilateral inguinal hernia repair. Methods: Fifty patients enrolled in this comparative study and were randomly assigned into two equal groups. One group received an ultrasound-guided QL block. In comparison, the other group received an ultrasound-guided TF plane block. The primary outcome was the patient-assessed resting, and movement-induced pain on the numeric pain rating scale (NRS) measured at 30 minutes postoperatively. Secondary outcomes included the percentage of patients receiving rescue analgesia in the first postoperative day, ease of performance of the technique, and incidence of adverse effects. Results: There were no statistically significant differences in NRS at rest and with movement between the groups over the first 24 hours postoperatively. The proportion of patients that received postoperative rescue analgesics during the first 30 minutes postoperatively was 4% (n = 1) in the QL group compared to 12% (n = 3) in the TF group. However, the mean performance time of the TF block was shorter than that of the QL block, and the performance of the TF block appeared easier technically. Conclusions: The ultrasound-guided TF plane block could be as effective as the QL block in lowering pain scores and decreasing opioid consumption following nonrecurrent inguinal herniorrhaphy.
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Karim Ebrahim,Farshad H. Shirazi,Hosein Vatanpour,Abas zare,Farzad Kobarfard,Hadi Rabie 한국유방암학회 2014 Journal of breast cancer Vol.17 No.4
Purpose: Breast cancer is a significant health problem worldwide,accounting for a quarter of all cancer diagnoses in women. Current strategies for breast cancer treatment are not fully effective,and there is substantial interest in the identification of novelanticancer agents especially from natural products includingtoxins. Cytotoxins are polypeptides found in the venom of cobrasand have various physiological effects. In the present study,the anticancer potential of cytotoxin-II against the human breastadenocarcinoma cell line (MCF-7) was investigated. Methods:The cytotoxic effects of cytotoxin-II were determined by morphologicalanalysis and 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazoliumbromide assay. The mode and mechanism of celldeath were investigated via acridine orange/ethidium bromide(AO/EtBr) double staining, flow cytometric analysis of cell death,detection of mitochondrial membrane potential, measurement ofintracellular reactive oxygen species (ROS), annexin V/propidiumiodide staining, and caspase-9 activity assays. Results: The halfmaximal inhibitory concentration (IC50) of cytotoxin-II in MCF-7cells was 4.18±1.23 μg/mL, while the value for cisplatin was approximately28.02±1.87 μg/mL. Morphological analysis and AO/EtBr double staining showed typical manifestations of apoptoticcell death (in doses lower than 8 μg/mL). Dose- and time-dependentROS generation, loss of mitochondrial membrane potential,caspase-9 activation, and cell cycle arrest were observed in theirrespective tests. Conclusion: In conclusion, cytotoxin-II has potentanticancer effects in the MCF-7 cell line, which are inducedvia the intrinsic pathways of apoptosis. Based on these findings,cytotoxin-II is a suitable choice for breast cancer treatment.
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