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Awwad A. Radwan,Kamal E. H. elTahir 대한약학회 2013 Archives of Pharmacal Research Vol.36 No.5
The synthesis of several 4-phenyl-5-pyridin-4-yl-2,3-dihydro-3H-1,2,4-triazole-3-thiones possessing N-2Mannich bases or S-alkyl substituents, is reported. Severalof them exhibited a low nanomolar COX enzyme inhibitionactivity. Most of the compounds showed inhibition ofedema was similar to that evoked by celocoxib in animalmodel. Molecular docking studies of the compounds intothe binding sites of COX-1 and COX-2 allowed us to shedlight on the binding mode of these novel COX inhibitors.
One-step versus two-step dolomite calcitization (dedolomitization): differences and inferences
Omar A. Radwan,Ahmet U. Dogan,Mohamed A. Morsy,Michael A. Kaminski,John D. Humphrey,Eric H. Christiansen 한국지질과학협의회 2021 Geosciences Journal Vol.25 No.4
Polycrystalline calcite pseudomorphs after dolomite can exhibit mosaic or drusy fabric caused by replacement of the dolomite by calcite (one-step dedolomitization) or dolomite dissolution followed by calcite cementation (two-step dedolomitization), respectively. This study discusses the differences between the two types and interprets the characteristics of the fluid causing them. Conclusions drawn here are founded on a microscopic and petrophysical examination of an outcrop of Tuwaiq Mountain Formation, central Arabian Peninsula. Petrographic examination shows that dedolomite has distinct microfabrics in each part of the section. The lower part of the section is not affected by dolomite calcitization, the middle part is dominated by replacement fabrics, and the upper part is dominated by dissolution and/or cementation fabrics. Petrophysical examination shows a wider range of porosity and permeability values for the upper part of the section, relative to the middle and lower parts. One-step dedolomitization is characterized by preservation of the external morphology of the parent dolomite, confinement to the volume previously occupied by the dolomite, development of intracrystalline porosity and permeability that allows the fluid to maintain contact with the reaction front, and no significant effect on porosity of the original rock. Two-step dedolomitization is characterized by corrosion of the external morphology of the parent dolomite, association with other forms of calcite cementation, development without intracrystalline porosity and permeability, and positive or negative effects on the porosity. While one-step dedolomitization appears to occur within a stagnant zone of fluid circulation, the two-step dedolomitization is considered to reflect an active fluid-flow system.
Synthesis and Antimicrobial Activity of Certain New 1,2,4-Triazolo[1,5-a]Pyrimidine Derivatives
Yaser A.H. Mostafa,Mostafa A. Hussein,Awwad A. Radwan,Abd El-Hamid N. Kfafy 대한약학회 2008 Archives of Pharmacal Research Vol.31 No.3
Certain new derivatives of 1,2,4-triazolo[1,5-a]pyrimidines were synthesized through the reaction of 1,2,4-triazolo[1,5-a]pyrimidine-7-ol with ethyl bromoacetate to afford the ethyl acetate ester, which upon hydrazinolysis gives the corresponding hydrazide. The hydrazide is the key intermediate which was used for the synthesis of the target compounds. The structures of the new compounds were assigned by spectral and elemental methods of analyses. The synthesized compounds were tested for their in vitro antibacterial and antifungal activities. Most of the tested compounds showed comparable results with those of ampicillin and fluconazole reference drugs.
Abdelgawad, Iman A,Radwan, Noha H,Shafik, Roxan E,Shokralla, Hala A Asian Pacific Journal of Cancer Prevention 2016 Asian Pacific journal of cancer prevention Vol.17 No.3
Background: Multiple myeloma (MM) is influenced by genetic and micro-environmental changes. Malignant plasma cells produce an abnormal monoclonal immunoglobulin, as well as cytokines, such as IL-10 and IL-6 which stimulate cells of the bone marrow microenvironment (BMM) and cause dysfunction and failure of many organs. B cell activating factor (BAFF), IL6 and IL10 are known to influence the growth and survival of malignant clones. Aim: The objectives of the present study were to investigate the circulating levels of BAFF, IL-10 and IL-6, correlate them with well-known parameters of disease activity in patients with MM, and to detect their impact on patients' survival. Materials and Methods: This study was conducted on 89 newly diagnosed MM patients and seventy apparently healthy volunteers as a normal control group. BAFF, IL6, IL10 were measured by ELISA for both groups and survival analysis was performed for all patients. Results: Studied markers were higher in the MM patients compared to the normal control subjects. Patients survival was improved by high serum BAFF levels. Conclusions: High levels of BAFF were found to improve patients' survival. BAFF and IL-6 can be considered probable diagnostic markers for MM.
Mostafa M. Ghorab,Zienab H. Ismail,Mohamad Abdalla,Awwad A. Radwan 대한약학회 2013 Archives of Pharmacal Research Vol.36 No.6
A novel series of quinazolines 5–10, triazoloquinazolines11–17 and triazinoquinazoline 19 bearing abiologically active sulfonamide moiety were synthesized,utilizing methyl 2-isothiocyanato benzoate 2. Some of thenewly synthesized compounds revealed promising bacterialgrowth inhibition, compared with the ampicillin, as thereference drug. A LigandScout approach-generated pharmacophoremodel for the Staph aureus bacteria growthinhibition was done. The degree of fitting of the test setcompounds (3, 4, 6, 8, 11, 17) to the generated hypotheticalmodel revealed a qualitative measure of the more orless microbial inhibition of Staphylococcus aureus. Compounds(7, 8, 10, 12, 15, 17 and 22), which revealed significantactivity, are able to effectively satisfy the proposedpharmacophore geometry, using the energy accessibleconformers (Econf\20 kcal/mol).
Abdelgawad, Iman A.,Radwan, Noha H.,Shafik, Roxan E.,Shokralla, Hala A. Asian Pacific Journal of Cancer Prevention 2016 Asian Pacific journal of cancer prevention Vol.17 No.5
Background: Multiple myeloma (MM) is influenced by genetic and micro-environmental changes. Malignant plasma cells produce an abnormal monoclonal immunoglobulin, as well as cytokines, such as IL-10 and IL-6 which stimulate cells of the bone marrow microenvironment (BMM) and cause dysfunction and failure of many organs. B cell activating factor (BAFF), IL6, IL10 are known to influence the growth & survival of the malignant clone. Aim: The objectives of the present study were to investigate the circulating levels of BAFF, IL-10 and IL-6, correlate them with well-known parameters of disease activity in patients with MM, and to detect their impact on the patients' survival. Materials and Methods: This study was conducted on 89 newly diagnosed MM patients and seventy apparently healthy volunteers as a normal control group. BAFF, IL6, IL10 were measured by ELISA for both groups. Survival analysis was performed for all patients. Results: Studied markers were higher in the MM patients compared to the normal control subjects. Patients' survival was improved by high serum BAFF levels. Conclusions: High levels of BAFF were found to improve patients' survival. BAFF and IL-6 can be considered probable diagnostic markers for MM.
Synthesis and Antimicrobial Activity of Certain New 1,2,4-Triazolo[1,5-a]Pyrimidine Derivatives
Mostafa, Yaser A.H.,Hussein, Mostafa A.,Radwan, Awwad A.,Krafy, Abd El-Hamid 대한약학회 2008 Archives of Pharmacal Research Vol.31 No.3
Certain new derivatives of 1,2,4-triazolo[1,5-a]pyrimidines were synthesized through the reaction of 1,2,4-triazolo[1,5-a]pyrimidine-7-o1 with ethyl bromoacetate to afford the ethyl acetate ester, which upon hydrazinolysis gives the corresponding hydrazide. The hydrazide is the key intermediate which was used for the synthesis of the target compounds. The structures of the new compounds were assigned by spectral and elemental methods of analyses. The synthesized compounds were tested for their in vitro antibacterial and antifungal activities. Most of the tested compounds showed comparable results with those of ampicillin and fluconazole reference drugs.
Synthesis of New 2-Thiouracil-5-Sulfonamide Derivatives with Biological Activity
Fathalla, O.A.,Zaghary, W.A.,Radwan, H.H.,Awad, S.M.,Mohamed, M.S. The Pharmaceutical Society of Korea 2002 Archives of Pharmacal Research Vol.25 No.3
2-Thiouracil-5-sulfonylchloride 1 reacted with a series of aromatic and heterocyclic amines to give 2a-j. The same compound 1 was reacted with a series of sulphonamides giving different sulphonamides of type 3a-e. On the other hand compound 1 was allowed to react with p-aminoacetophenone givining compound 4 which in turn was allowed to react with derivatives of alkyl thiosemicarbazides to give thiosemicarbazones of type 5a-e, also compound 4 was monobrominated to give compound 6 which in turn was reacted thiosemicarbazones of some aldehydes to give the corresponding thiazole derivatives 7a-f. In the same time compound 4 was reacted with a series of aromatic and heterocyclic aldehydes givining chalcones 8a-g (Claisen-Schemidt reaction). Also compound 4 was allowed to react with a series of aromatic and heterocyclic aldehydes, ethyl cyano acetate and/or malononitrile, and ammonium acetate giving pyridine derivatives 9a-d and 10a-e respectively. The biological effects of some of the new synthesized compounds was also investigated.
DC Motor Speed Control via FoPID-Controllers
Iqbal M. Batiha,Shaher Momani,Radwan M. Batyha,Iqbal H. Jebril,Duha Abu Judeh,Jamal Oudetallah 한국지능시스템학회 2024 INTERNATIONAL JOURNAL of FUZZY LOGIC and INTELLIGE Vol.24 No.1
This work aims to propose several designs for controlling the DC motor speed of a car. Suchmotor is broadly used in numerous applications like blowers, lathe machines, cranes, elevators,milling machines, fans, drilling rigs, etc. For achieving our aim, two optimization algorithms(Particle Swarm Optimization (PSO) and Bacterial Foraging Optimization (BFO)) will beexecuted to adjust the proposed controllers’ parameters. Accordingly, four Fractional-orderPID controllers (FoPID-controllers) will be formed in agreement with two types of schemes(Outstaloup’s and Continued Fraction Expansion (CFE) schemes), which will be used toapproximate the yielded Laplacian operators s±α, where 0 < α < 1.