언론의 자유와 프라이버시권에 관한 고찰

김권일 연세대학교 언론연구소 1993 언론 사회 문화 Vol.- No.3

Resveratrol attenuates matrix metalloproteinase-9 and -2- regulated differentiation of HTB94 chondrosarcoma cells through the p38 kinase and JNK pathways

GWEON, EUN JEONG,KIM, SONG-JA Spandidos Publications 2014 ONCOLOGY REPORTS Vol.32 No.1

<P>Resveratrol has been shown to possess anticancer, anti-aging, and anti-inflammatory properties. Matrix metalloproteinases (MMPs) appear to be responsible for much of the extracellular matrix (ECM) degradation observed in the progression of cancer, aging and inflammation. We found that resveratrol significantly inhibited MMP-2 and MMP-9, and induced the expression of type II collagen and sex-determining region Y-box (SOX)-9 and the production of sulfated proteoglycans in HTB94 chondrosarcoma cells. Moreover, inhibition of MMPs with an MMP inhibitor further enhanced the effects of resveratrol. Phosphorylation of p38 was increased and phosphorylation of c-Jun N-terminal kinase (JNK) was inhibited by resveratrol. Treatment with SB203580, a p38 kinase inhibitor, enhanced the suppression of MMP-2 and MMP-9 by resveratrol and inhibited resveratrol-induced stimulation of type II collagen and SOX-9 expression and production of sulfated proteoglycans. Treatment with SP600125, a JNK inhibitor, attenuated the effects of resveratrol on MMP-2 and MMP-9, and accelerated resveratrol-induced effects on type II collagen, SOX-9 and sulfated proteoglycan production. Our results suggest that resveratrol inhibits MMP-induced differentiation via the p38 kinase and JNK pathways in HTB94 chondrosarcoma cells.</P>

Fecal Microbiota Transplantation Using Upper Gastrointestinal Tract for the Treatment of Refractory or Severe Complicated <i> Clostridium difficile</i> Infection in Elderly Patients in Poor Medical Condition: The First Study in an Asian Country

Gweon, Tae-Geun,Kim, Jinsu,Lim, Chul-Hyun,Park, Jae Myung,Lee, Dong-Gun,Lee, In Seok,Cho, Young-Seok,Kim, Sang Woo,Choi, Myung-Gyu Hindawi Publishing Corporation 2016 Gastroenterology Research and Practice Vol.2016 No.-

<P><I>Background and Aims</I>. Fecal microbiota transplantation (FMT) is a highly effective treatment option for refractory<I> Clostridium difficile</I> infection (CDI). FMT may be challenging in patients with a low performance status, because of their poor medical condition. The aims of this study were to describe our experience treating patients in poor medical condition with refractory or severe complicated CDI using FMT via the upper GI tract route.<I> Methods</I>. This study was a retrospective review of seven elderly patients with refractory or severe complicated CDI and a poor medical condition who were treated with FMT through the upper GI tract route from May 2012 through August 2013. The outcomes studied included the cure rate of CDI and adverse events.<I> Results</I>. Of these seven patients who received FMT via the upper GI tract route, all patients were cured. During the 11-month follow-up period, CDI recurrence was observed in two patients; rescue FMT was performed in these patients, which led to a full cure. Vomiting was observed in two patients.<I> Conclusions</I>. FMT via the upper gastrointestinal tract route may be effective for the treatment of refractory or severe complicated CDI in patients with a low performance status. Physicians should be aware of adverse events, especially vomiting.</P>

Relative strength of perpendicular magnetic anisotropy at bottom and top interfaces in Pt/Co/MgO trilayers

Gweon, Hyung Keun,Lim, Sang Ho Institute of Pure and Applied Physics 2018 Japanese Journal of Applied Physics Vol. No.

<P>In Pt/Co/MgO trilayers, the contribution to the total perpendicular magnetic anisotropy from the bottom Pt/Co interface is significantly greater than that from the top Co/MgO interface at intermediate annealing temperatures. However, the relative contribution is reversed at the highest annealing temperature examined in this study, 400 degrees C. These results indicate that as the annealing temperature increases, the quality of the Pt/Co interface deteriorates owing to the intermixing of Pt and Co, whereas the quality of the Co/MgO interface improves as oxygen atoms, which are interpenetrated into the Co layer during the deposition of MgO, are diffused toward the Co/MgO interface. (C) 2018 The Japan Society of Applied Physics</P>

Trimodal imaging endoscopy reduces the risk of synchronous gastric neoplasia

Gweon, Tae-Geun,Park, Jae Myung,Lim, Chul-Hyun,Kim, Jin Su,Cho, Yu Kyung,Kim, Sang Woo,Choi, Myung-Gyu Wolters Kluwer Health, Inc. All rights reserved. 2015 European journal of gastroenterology & hepatology Vol.27 No.3

BACKGROUND AND AIM: The accurate detection of synchronous neoplasia is important to reduce the risk of recurrence after endoscopic resection. Trimodal imaging endoscopy (TMIE) was developed for this purpose. Our aim was to compare the effects of TMIE and white-light imaging endoscopy (WLIE) in gastric neoplasia detection. PATIENTS AND METHODS: Six hundred and seventy-eight patients with gastric dysplasia or cancer initially treated by endoscopic resection and who underwent follow-up endoscopy were analyzed retrospectively. Gastric neoplasia detected within 1 year of endoscopic resection was defined as synchronous disease. WLIE or TMIE was used to detect another gastric neoplasia before endoscopic resection. RESULTS: Synchronous gastric neoplasia was observed in 41 patients (6%), and occurred more frequently after the resection of carcinoma than dysplasia (8.5 vs. 4.6%, P=0.04). TMIE significantly reduced the frequency of synchronous gastric lesions than WLIE (2.3 vs. 9.3%, P<0.01). TMIE was more effective than WLIE in reducing the risk of missing a synchronous gastric lesion after adjusting for lesion multiplicity, experience, and resected lesion pathology (hazard ratio, 0.32; 95% confidence interval, 0.108–0.762). CONCLUSION: The risk of missing synchronous gastric neoplasia is higher after endoscopic resection for gastric cancer than dysplasia, but is reduced by TMIE. TMIE before endoscopic treatment can be useful in decreasing the risk of synchronous gastric neoplasia.

A NEW SCHEME FOR RAPID CDMA PILOT CHANNEL ACQUISITION

Gweon Do Jo 한국통신학회 1995 Asia-Pacific Conference on Communications Vol.1 No.1

Prospective, Randomized Comparison of Same-Day Dose of 2 Different Bowel Cleanser for Afternoon Colonoscopy : Picosulfate, Magnesium Oxide, and Citric Acid Versus Polyethylene Glycol

Gweon, Tae-Geun,Kim, Sang Woo,Noh, Yong-Sun,Hwang, Seawon,Kim, Na-Young,Lee, Yoonbum,Lee, Soon-Wook,Lee, Sung Won,Lee, Jong Yul,Lim, Chul-Hyun,Hun Kim, Hyung,Kim, Jin Su,Kyung Cho, Yu,Myung Park, Jae Wolters Kluwer Health 2015 Medicine Vol.94 No.13

<P><B>Abstract</B></P><P>For afternoon colonoscopy, same-day administration of sodium picosulfate, magnesium oxide, and citric acid (PM/Ca) is recommended. However, few studies have evaluated the bowel-cleansing efficacy and safety of this regimen. The aim of this study was to compare the bowel-cleansing efficacy, side effects, and patient's tolerability of a same-day split administration of PM/Ca with polyethylene glycol (PEG) for afternoon colonoscopy.</P><P>Patients were randomly assigned to a PM/Ca group or a PEG group. The PM/Ca group consumed 1 sachet of PM/Ca at 06:00 and 1 sachet of PM/Ca 4 hours before the colonoscopy. They also took 2 tablets of bisacodyl before sleep on the night before. The PEG group consumed 2 L of PEG at 06:00 and 2 L of PEG 4 hours before the colonoscopy. All subjects were instructed to finish the bowel cleanser or fluid at least 2 hours before colonoscopy. All colonoscopic examinations were performed in the afternoon on the same day. The bowel-cleansing efficacy was scored using 2 scales: the Ottawa Bowel Preparation Scale (OBPS) and the Aronchick scale. Ease of using the bowel cleanser was rated from 1 (very easy) to 5 (very difficult).</P><P>Two hundred nine patients underwent colonoscopy. The bowel-cleansing scores by OBPS did not differ between groups (5.0 vs 4.9, <I>P</I> = 0.63). Ease of using the bowel cleanser was superior in the PM/Ca group (<I>P</I> < 0.01).</P><P>The cleansing efficacy of PM/Ca administered on the day of colonoscopy is comparable to that of PEG. Patients prefer PM/Ca.</P>

Hematologic diseases: high risk of Clostridium difficile associated diarrhea.

Gweon, Tae-Geun,Choi, Myung-Gyu,Baeg, Myong Ki,Lim, Chul-Hyun,Park, Jae Myung,Lee, In Seok,Kim, Sang Woo,Lee, Dong-Gun,Park, Yeon Joon,Lee, Jong Wook WJG Press 2014 WORLD JOURNAL OF GASTROENTEROLOGY Vol.20 No.21

<P>To investigate the incidence and clinical outcome of Clostridium difficile (C. difficile) associated diarrhea (CDAD) in patients with hematologic disease.</P>

$^{13}C-^{1}H$ Coupling Constant as a Criterion for the Presence of $\pi$ Bridging in Substituted 9-Benzonorbornenyl Cation

Gweon-Young Ryu,Jung-Hyu Shin Korean Chemical Society 1993 Bulletin of the Korean Chemical Society Vol.14 No.5

The discrete structure of substituted 9-benzonorbornenyl cation 3a and 3c was studied using the empirical ${\Delta}$J equation which was developed by Kelly and coworker$^5$. The ${\Delta}$J values of substituted 9-benzonorbornenyl cations were obtained from p-methyl-6,7-dimethyl benzonorbornen-9-yl (3a) and 9-methyl-6,7-dimethyl benzonorbonen-9-yl (3c) cations under stable ion conditions, and were compared with those of the corresponding ketone analog; these cations were generated by dissolving the corresponding carbinols in superacid at -120$^{\circ}$C and the nmr spectra taken at -60$^{\circ}$C~-90$^{\circ}$C. The ${\Delta}$J values are 8.7 Hz for the bridgehead carbons in cation 3c and 3.1 Hz for cation 3b. The ${\Delta}$J values at C5,8 in fused benzene ring are 14.3 Hz for cation 3c and 8.7 Hz for cation 3a. The excellent correlation of the ${\Delta}$J values with 1$^9F$ chemical shifts of p-fluorophenyl-6,7-dimethylbenzonorbornenyl cation (3d) indicate that ${\Delta}$J value is a reliable probe to charge density at adjacent cationic carbon. These NMR parameters strongly support that the symmetrically ${\pi}$-bridged nonclassical structure (type 2) of substituted 9-benzonorbornenyl cations in stable ion conditions.

Prolongation of Neuromuscular Block of Succinylcholine Chloride by Ketamine in Rabbits

Gweon, Kyeong Deog,Chung, Woon Hyok CATHOLIC MEDICAL CENTER 1980 Bulletin of the Clinical Research Institute Vol.8 No.1

The effect of ketamine on the muscle relaxation produced by succinylcholine chloride was studied. The cause of prolongation of neuromuscular block of succinylcholine chloride by ketamine was discussed. The clinical dose of S.C.C. should be carefully adjusted, if ketamine would be administered.