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RISS 인기검색어
- 검색키워드
- 저자 : Gjustina Loloci (검색결과 2 건)
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Loloci Gjustina,Kim Yu Min,Choi Won-Il,Jang Hye Jin,Park Sang Joon,Kwon Kun Young 대한의학회 2023 Journal of Korean medical science Vol.38 No.31
Background: Profibrotic properties of pleural mesothelial cells may play an important role in the fibrosis activity in idiopathic pulmonary fibrosis (IPF). The purpose of this study was to compare the expression of pleural mesothelial cell markers in IPF and cryptogenic organizing pneumonia (COP), with an assumption that increased expression implies increase in fibrosis. Methods: Twenty IPF lung samples were stained by immunohistochemistry for the pleural mesothelial cell markers: leucine rich repeat neuronal 4 (LRRN4), uroplakin 3B, CCchemokine ligand 18, and laminin-5. Nine COP lung samples were used as controls. A semiquantitative analysis was performed to compare markers expression in IPF and COP. Results: LRRN4 expression was found in epithelial lining cells along the honeycombing and fibroblastic foci in IPF, but not in the fibrotic interstitial lesion and airspace filling fibrous tufts in COP. We found a significant decrease in baseline forced vital capacity when LRRN4 expression was increased in honeycombing epithelial cells and fibroblastic foci. Conclusion: LRRN4 expression patterns in IPF are distinct from those in COP. Our findings suggest that mesothelial cell profibrotic property may be an important player in IPF pathogenesis and may be a clue in the irreversibility of fibrosis in IPF.
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Association between Antacid Exposure and Risk of Interstitial Lung Diseases
Won-Il Choi,Soohyun Bae,Gjustina Loloci,Dong Yoon Lee,Hye Jin Jang,Jihyeon Jeong 대한결핵및호흡기학회 2024 Tuberculosis and Respiratory Diseases Vol.87 No.2
Background: The mechanisms leading to lung fibrosis are still under investigation. Thisstudy aimed to demonstrate whether antacids could prevent the development of interstitiallung disease (ILD). Methods: This population-based longitudinal cohort study was conducted betweenJanuary 2006 and December 2010 in South Korea. Eligible subjects were ≥40 years ofage, exposed to proton pump inhibitors (PPI)±histamine-2 receptor antagonists (H-2blockers) or H-2 blockers only, and had no history of ILD between 2004 and 2005. Exposure to antacids was defined as the administration of either PPI or H-2 receptorantagonists for >14 days, whereas underexposure was defined as antacid treatmentadministered for less than 14 days. Newly developed ILDs, including idiopathic pulmonaryfibrosis (IPF), were counted during the 5-year observation period. The associationbetween antacid exposure and ILD development was evaluated using adjusted Coxregression models with variables, such as age, sex, smoking history, and comorbidities. Results: The incidence rates of ILD with/without antacid use were 43.2 and33.8/100,000 person-years, respectively and those of IPF were 14.9 and 22.9/100,000person-years, respectively. In multivariable analysis, exposure to antacid before the diagnosisof ILD was independently associated with a reduced development of ILD (hazardratio [HR], 0.57; 95% confidence interval [CI], 0.45 to 0.71; p<0.001), while antacidexposure was not associated with development of IPF (HR, 0.88; 95% CI, 0.72 to 1.09;p=0.06). Conclusion: Antacid exposure may be independently associated with a decreased riskof ILD development.
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