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Michael D. McAlpine,William Gittings,Adam J. MacNeil,Wendy E. Ward 한국식품영양과학회 2021 Journal of medicinal food Vol.24 No.8
Many human studies suggest a benefit of tea consumption on bone health. The study objective was to compare the ability of different tea types to promote mineralization. Saos-2 cells underwent mineralization (5 days) in the presence of tea (white: WT, green: GT, black: BT, green rooibos: GR, or red rooibos: RR; 1 μg/mL of polyphenols) or control. Total polyphenol content (TPC, Folin-Ciocalteu's reagent), antioxidant capacity (2,2-diphenyl-1-picrylhydrazyl [DPPH] scavenging), mineralization (Alizarin Red staining), gene expression quantitative reverse transcription PCR (RT-qPCR), and cell activity (3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyltetrazolium bromide assay) were determined. TPC was highest in GT and BT. The ability of each tea to inhibit DPPH also differed (WT, GT > RR) after normalizing for polyphenol quantity. Each tea increased mineralization and differences were observed among types (GT/BT/GR/RR > WT, GT = BT = GR, RR > BT/GT). mRNA expression of alkaline phosphatase (ALP) and ectonucleotide pyrophosphatase/phosphodiesterase (NPP1) remained unchanged, whereas osteopontin (OPN) and sclerostin (SOST) were reduced in cells treated with tea, regardless of type. At 24- and 48-h postexposure to tea, cell activity was greater in cells receiving any of the teas compared with vehicle control. Supplementation increased mineralization regardless of tea type with both rooibos teas and black tea stimulating greater mineralization than WT, whereas green tea is similar to the others. While future study is needed to confirm in vivo effects, the results suggest that consuming any of the teas studied may benefit bone health.
Boyce - Codd 정규형을 위한 효율적인 알고리즘의 설계 및 구현
김기백(Git-Baeg Kim),서영훈(Young-Hoon Seo),정순기(Soon-Gli Jung) 한국정보과학회 1990 한국정보과학회 학술발표논문집 Vol.17 No.2
관계 데이타베이스 시스템의 설계에 있어 연산상의 이상을 배제하기 위해서 relation의 정규화가 요구되며, 이에 따라 정규화 알고리즘이 개발되어 왔다. 그러나 기존의 정규화 알고리즘에서는 정규형의 단계에 의존해 정규화 과정을 수행하여 연산의 중복이 발생되었다. 본 연구에서는 Boyce-Codd 정규형으로 정규화하는 알고리즘을 구성함에 있어 함수적 종속성에 중점을 두어, 중복되는 closure 계산량을 줄이는 알고리즘을 구성하고, 이를 구현하였다.