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      • THESEUS: A key space mission concept for Multi-Messenger Astrophysics

        Stratta, G.,Ciolfi, R.,Amati, L.,Bozzo, E.,Ghirlanda, G.,Maiorano, E.,Nicastro, L.,Rossi, A.,Vinciguerra, S.,Frontera, F.,,tz, D.,Guidorzi, C.,O’Brien, P.,Osborne, J.P.,Tanvir, N.,Branchesi, M. Elsevier 2018 ADVANCES IN SPACE RESEARCH Vol.62 No.3

        <P><B>Abstract</B></P> <P>The recent discovery of the electromagnetic counterpart of the gravitational wave source GW170817, has demonstrated the huge informative power of multi-messenger observations. During the next decade the nascent field of multi-messenger astronomy will mature significantly. Around 2030 and beyond, third generation ground-based gravitational wave detectors will be roughly ten times more sensitive than the current ones. At the same time, neutrino detectors currently upgrading to multi km<SUP>3</SUP> telescopes, will include a 10 km<SUP>3</SUP> facility in the Southern hemisphere. In this review, we describe the most promising sources of high frequency gravitational waves and neutrinos that will be detected in the next two decades. In this context, we show the important role of the <I>Transient High Energy Sky and Early Universe Surveyor</I> (THESEUS), a mission concept accepted by ESA for phase A study and proposed by a large international collaboration in response to the call for the Cosmic Vision Programme M5 missions. THESEUS aims at providing a substantial advancement in early Universe science as well as in multi–messenger and time–domain astrophysics, operating in strong synergy with future gravitational wave and neutrino detectors as well as major ground- and space-based telescopes. This review is an extension of the THESEUS white paper (Amati et al., 2017), also in light of the discovery of GW170817/GRB170817A that was announced on October 16th, 2017.</P>

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        Functional Status in Older Adults following Hospitalization for COVID-19: A Cohort Study

        Pía Izaguirre,Érica Arakaki,Jorge Vogt Boero,Ángeles Zalazar,Mariano Ghirlanda,Diego Caruso 대한노인병학회 2023 Annals of geriatric medicine and research Vol.27 No.4

        Background: Coronavirus disease 2019 (COVID-19) can cause multiple acute complications. This study evaluated the long-term functional status of older patients hospitalized for acute COVID-19. Methods: We analyzed data from a multicenter ambispective cohort study on patients aged >60 years who were hospitalized for COVID-19 at two tertiary care hospitals in Argentina. The participants were contacted by telephone between November 2021 and September 2022 to collect data on their functional status. Ordinal logistic regression was used to identify factors associated with functional limitations after discharge. Results: Among the 374 included patients, 205 (55%) showed functional limitations, including 58 (28%) who died during follow-up. The factors independently associated with functional limitations were low baseline functional status (odds ratio [OR]=9.19; 95% confidence interval [CI], 3.35–25.17) and admission to the intensive care unit (OR=4.41; 95% CI, 2.28–8.53). Men had lower odds of functional impairment (OR=0.55; 95% CI, 0.35–0.86). Conclusion: Older patients had high mortality rates and poor functional status at 2 years post-discharge for COVID-19. Several factors at the time of discharge were associated with a higher risk of functional limitations and can be used to identify patients’ long-term needs for support and rehabilitation services.

      • The THESEUS space mission concept: science case, design and expected performances

        Amati, L.,O’Brien, P.,,tz, D.,Bozzo, E.,Tenzer, C.,Frontera, F.,Ghirlanda, G.,Labanti, C.,Osborne, J.P.,Stratta, G.,Tanvir, N.,Willingale, R.,Attina, P.,Campana, R.,Castro-Tirado, A.J.,Contini, Elsevier 2018 ADVANCES IN SPACE RESEARCH Vol.62 No.1

        <P><B>Abstract</B></P> <P>THESEUS is a space mission concept aimed at exploiting Gamma-Ray Bursts for investigating the early Universe and at providing a substantial advancement of multi-messenger and time-domain astrophysics. These goals will be achieved through a unique combination of instruments allowing GRB and X-ray transient detection over a broad field of view (more than 1sr) with 0.5–1 arcmin localization, an energy band extending from several MeV down to 0.3 keV and high sensitivity to transient sources in the soft X-ray domain, as well as on-board prompt (few minutes) follow-up with a 0.7 m class IR telescope with both imaging and spectroscopic capabilities. THESEUS will be perfectly suited for addressing the main open issues in cosmology such as, e.g., star formation rate and metallicity evolution of the inter-stellar and intra-galactic medium up to redshift ∼ 10, signatures of Pop III stars, sources and physics of re-ionization, and the faint end of the galaxy luminosity function. In addition, it will provide unprecedented capability to monitor the X-ray variable sky, thus detecting, localizing, and identifying the electromagnetic counterparts to sources of gravitational radiation, which may be routinely detected in the late ’20s/early ’30s by next generation facilities like aLIGO/ aVirgo, eLISA, KAGRA, and Einstein Telescope. THESEUS will also provide powerful synergies with the next generation of multi-wavelength observatories (e.g., LSST, ELT, SKA, CTA, ATHENA).</P>

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