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Cheolwon Suh,Sang Hee Kim,Hyo Jung Kim,Geundoo Jang,Eun Kyung Kim,Ok Bae Ko,Shin Kim,Hee Jung Sohn,Jung Shin Lee,Wookun Kim,Jooryung Huh 대한암학회 2005 Cancer Research and Treatment Vol.37 No.5
Purpose: Autologous stem cell transplantation (ASCT) is increasingly used in patients with non-Hodgkin’s lymphoma (NHL). Various clinical parameters-wereevaluated to obtain significant predictors of the outcome following ASCT in patients with NHLMaterials and Methods: Between April 1994 and December 2003, ASCT was performed on 80 patients with NHL at the Asan Medical Center. Results: Patients had various histological subtypes and disease status. The two year progression free survival (PFS) and overall survival for all patients were 34 and 31%, respectively. A univariate analysis showed the performance status, stage, modified extranodal involvement category, International Prognostic Index (IPI) at mobilization, disease status at mobilization, and history of radiation prior to mobilization as significant predictors of the outcome following ASCT. Four risk groups, with different 2 year PFS, were identified by the age adjusted IPI at mobilization (mAAIPI): low risk 44%; low intermediate risk 40%; high intermediate risk 19%; and high risk 0% (p=.0003). A multivariate analysis revealed 3 significant factors for the PFS: disease status, prior RT and mAAIPI. Conclusion: The mAAIPI was found to be an independent predictor of the outcome of NHL patients undergoing ASCT. This powerful prognostic tool should be used to evaluate potential candidates for ASCT.
뼈 전이를 동반한 진행성 위암 환자에서의 Flare Phenomenon
이상기 ( Sangki Lee ),시혜진 ( Hyejin Shi ),손성민 ( Sungmin Sohn ),박성락 ( Sungrock Park ),왕성호 ( Sungho Wang ),송진경 ( Jinkyung Song ),장근두 ( Geundoo Jang ) 대한내과학회 2016 대한내과학회지 Vol.91 No.3
Flare phenomenon refers to increased radiotracer uptake in bones despite clinical findings showing a positive response to treatment. Flare phenomena are most often observed in patients with breast or prostate cancer. Here, we present a case of bone flare in a 54-year-old male who had advanced gastric cancer with bone metastases. After three cycles of chemotherapy, a bone scan showed increased intensity, but the patient`s bone pain was alleviated and abdominal computed tomography revealed a decrease in the size of the primary mass and metastatic lymph nodes. We therefore continued chemotherapy using the same regimen, and a follow- up bone scan revealed decreased intensity. A flare phenomenon after treatment is rare in cases of gastric cancer with bone metastasis. Although flare phenomena are not common, they should be considered in patients with gastric cancer when the clinical results are inconsistent with bone-scan findings. (Korean J Med 2016;91:321-324)