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Gaihre, Babita,Hee Lee, Young,Seob Khil, Myung,Keun Yi, Ho,Yong Kim, Hak Informa UK, Ltd. 2011 Journal of microencapsulation Vol.28 No.4
<P>The aim of this study was to modify the surfaces of magnetic iron oxide nanoparticles (IOPs) with gelatin in order to reduce cytotoxicity and enhance cellular uptake. The gelatin-coated IOPs were characterized in terms of their functionalization, size, surface charge, morphology and crystalline structure using Fourier transform infrared (FT-IR) spectroscopy, thermogravimetric analysis (TGA), dynamic light scattering (DLS), transmission electron microscopy (BIO-TEM) and x-ray diffraction (XRD) analysis. The cytotoxicity of the gelatin-coated IOPs to human fibroblasts was assessed using an MTT-assay and was compared with uncoated IOPs. Similarly, the cellular uptake of the coated and uncoated IOPs was visualized using BIO-TEM and quantified using inductively coupled plasma spectroscopy (ICPS). As shown by the Fourier emission scanning electron microscopy (FE-SEM) and viability test, the massive uptake of uncoated IOPs lead to reduced viability. However, gelatin coating lead to increased viability and slow uptake without any visible distortion to the cell morphology.</P>
Gaihre, Babita,Aryal, Santosh,Barakat, Nasser A.M.,Kim, Hak Y. Elsevier S.A. 2008 Materials Science and Engineering C Vol. No.
<P><B>Abstract</B></P><P>Inspired by the structural similarity of gelatin (and collagen) linked to a mineral phase based on Ca-phosphates compounds with natural bone and increasing application of magnetic iron oxides in hyperthermia, gelatin coated iron oxide (GIO) was synthesized and hydroxyapatite (HAp) crystal nucleation and growth in the nanoparticles was explored. A series of GIO/HAp nanocomposites with various amount of GIO were synthesized by co-precipitation technique using calcium hydroxide and phosphoric acid as precursor. Various physico-chemical analysis showed that the HAp crystal nucleation and growth occurred at acidic group of gelatin, while magnetic iron oxide nanoparticles (< 8nm) were bound to the amide groups of the gelatin chain. Moreover, the growth of HAp nanocrystals in aq. GIO solution was highly influenced by the GIO contents in the solution. The mineralized composite with magnetic properties could have great scope in biomedical field as a thermoseed to kill the cancerous cell in bone side by side for the bone reinforcement.</P>