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RISS 인기검색어
- 검색키워드
- 저자 : Fisch, Michael R. (검색결과 5 건)
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Heidrun Gehlen,Judith Fisch,Roswitha Merle,Dagmar S. Trachsel 대한수의학회 2021 Journal of Veterinary Science Vol.22 No.5
Background: Pituitary pars intermedia dysfunction (PPID), a neurodegenerative disease leading to reduced dopamine production, is a common disease in aged horses. The treatment is based on administration of the dopamine agonist pergolide. This drug has been related to valvular fibrosis in humans, but the cardiovascular effect of this drug has not yet been investigated in horses. Objectives: To determine whether pergolide induces valvular disease in horses or affects the cardiac function. Methods: Standard, tissue Doppler (TDE) and two-dimensional speckle tracking (STE) echocardiography were performed in horses with diagnosed PPID based on adrenocorticotropic hormone dosage. Measurements taken in horses treated with pergolide were compared with those from untreated horses with nonparametric t-tests. Furthermore, measurements from follow-up examinations performed at least three months after the initial exam were compared with a Wilcoxon signed rank test for repeated measurements in each group. Results: Twenty-three horses were included. None of the 12 horses under treatment developed valvular regurgitation. Furthermore, no differences in the measurements of the left ventricular systolic or diastolic function could be seen between the group of horses with treatment and those without treatment. Measurements taken in the follow-up exam did not differ compared to those taken in the initial exam in both groups. Conclusions: No changes of the left ventricular function assessed by TDE and STE could be shown in a small population of horses with confirmed PPID. Treatment with pergolide did not affect the ventricular function nor induce valvular disease.
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New Techniques for Fabrication of Flexible Plastic LCD's
West, John.L.,Novotny, Grea R.,Fisch, Michael R.,Heinman, David The Korean Infomation Display Society 2001 Journal of information display Vol.2 No.4
We report simple techniques to manufacture low-powered, high-resolution, reflective cholesteric displays using flexible plastic substrates. We use wax transfer printing to replace photo-lithography and incorporate polymer walls to increase the mechanical strength and lifetime of the displays. These printing methods can easily be adapted to roll-to-roll production.
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Sylvia Weis,Tim A. Ludwig,Omar Bahassan,Philipp Gild,Malte W. Vetterlein,Margit Fisch,Roland Dahlem,Valentin Maurer 대한배뇨장애요실금학회 2023 International Neurourology Journal Vol.27 No.2
Purpose: This study investigated the functional outcomes and complication rates of cuff downsizing for the treatment of recurrent or persistent stress urinary incontinence (SUI) in men after the implantation of an artificial urinary sphincter (AUS). Methods: Data from our institutional AUS database spanning the period from 2009 to 2020 were retrospectively analyzed. The number of pads per day was determined, a standardized quality of life (QoL) questionnaire and the International Consultation on Incontinence Questionnaire (ICIQ) were administered, and postoperative complications according to the ClavienDindo classification were analyzed. Results: Out of 477 patients who received AUS implantation during the study period, 25 (5.2%) underwent cuff downsizing (median age, 77 years; interquartile range [IQR], 74–81 years; median follow-up, 4.4 years; IQR, 3–6.9 years). Before downsizing, SUI was very severe (ICIQ score 19–21) or severe (ICQ score 13–18) in 80% of patients, moderate (ICIQ score 6–12) in 12%, and slight (ICIQ score 1–5) in 8%. After downsizing, 52% showed an improvement of >5 out of 21 points. However, 28% still had very severe or severe SUI, 48% had moderate SUI, and 20% had slight SUI. One patient no longer had SUI. In 52% of patients, the use of pads per day was reduced by ≥50%. QoL improved by >2 out of 6 points in 56% of patients. Complications (infections/urethral erosions) requiring device explantation occurred in 36% of patients, with a median time to event of 14.5 months. Conclusions: Although cuff downsizing carries a risk of AUS explantation, it can be a valuable treatment option for selected patients with persistent or recurrent SUI after AUS implantation. Over half of patients experienced improvements in symptoms, satisfaction, ICIQ scores, and pad use. It is important to inform patients about the potential risks and benefits of AUS to manage their expectations and assess individual risks.
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Inpatients hypospadias care: Trends and outcomes from the American nationwide inpatient sample
Christian Meyer,Shyam Sukumar,Akshay Sood,Julian Hanske,Malte Vetterlein,Jack S. Elder,Margit Fisch,Quoc-Dien Trinh,Ariella A. Friedman 대한비뇨의학회 2015 Investigative and Clinical Urology Vol.56 No.8
Purpose: Hypospadias is the most common congenital penile anomaly. Information about current utilization patterns of inpatienthypospadias repair as well as complication rates remain poorly evaluated. Materials and Methods: The Nationwide Inpatient Sample was used to identify all patients undergoing inpatient hypospadiasrepair between 1998 and 2010. Patient and hospital characteristics were attained and outcomes of interest included intra- and immediatepostoperative complications. Utilization was evaluated temporally and also according to patient and hospital characteristics. Predictors of complications and excess length of stay were evaluated by logistic regression models. Results: A weighted 10,201 patients underwent inpatient hypospadias repair between 1998 and 2010. Half were infants (52.2%),and were operated in urban and teaching hospitals. Trend analyses demonstrated a decline in incidence of inpatient hypospadiasrepair (estimated annual percentage change, –6.80%; range, –0.51% to –12.69%; p=0.037). Postoperative complication rate was4.9% and most commonly wound-related. Hospital volume was inversely related to complication rates. Specifically, higher hospitalvolume (>31 cases annually) was the only variable associated with decreased postoperative complications. Conclusions: Inpatient hypospadias repair have substantially decreased since the late 1990’s. Older age groups and presumablymore complex procedures constitute most of the inpatient procedures nowadays.
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