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- 저자 : Fengguo Liu (검색결과 3 건)
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Photopolymerization of UV Curable Coatings Monitored by Raman Spectroscopy
Fengguo Liu,Ying Wang,Xiangxin Xue,He Yang 한국고분자학회 2016 폴리머 Vol.40 No.3
Photopolymerization process of UV curable coatings based on epoxy acrylate/tripropylene glycol diacrylate was monitored by Raman spectroscopy. The consumption of C=C double bond in coatings was observed under UV irradiation. Quantitative analysis of curing degree versus UV irradiation time was investigated by fitting Raman spectra. The results indicated that the initiation efficiency of cleavage type photoinitiators and Irgacure 184 are superior to that of hydrogen-abstraction type photoinitiator. High photoinitiator concentration is beneficial for achieving fast photopolymerization rate and high final conversion. However, when the concentration of photoinitiator exceeds a certain value, the polymerization rate and final conversion will not increase evidently because of initiation efficiency and free volume effect.
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Feng Guo,Haijun Zhong,Jing He, Baogang Xie,Fen Liu, Helin Xu,Minmin Liu,Chunlian Xu 대한약학회 2011 Archives of Pharmacal Research Vol.34 No.7
Dipyridamole shows poor and variable bioavailability after oral administration due to pHdependent solubility, low biomembrane permeability as well as being a substrate of P-glycoprotein. In order to improve the oral absorption of dipyridamole, a self-microemulsifying drug delivery system (SMEDDS) for dipyridamole was prepared and evaluated in vitro and in vivo. The optimum formulation was 18% oleic acid, 12% Labrafac lipophile WL 1349, 42% Solutol HS 15 and 28% isopropyl alcohol. It was found that the performance of self-microemulsification with the combination of oleic acid and Labrafac lipophile WL 1349 increased compared with just one oil. The results obtained from an in vitro dissolution assay indicated that dipyridamole in SMEDDS dissolved rapidly and completely in pH 6.8 aqueous media, while the commercial drug tablet was less soluble. An oral bioavailability study in rats showed that dipyridamole in the SMEDDS formulation had a 2.06-fold increased absorption compared with the simple drug suspension. It was evident that SMEDDS may be an effective approach to improve the oral absorption for drugs having pH-dependent solubility.
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Feng Guo,Chengchun Tang,Bo Huang,Lifei Gu,Jun Zhou,Zongyang Mo,Chang Liu,Yuqing Liu 한국분자세포생물학회 2022 Molecules and cells Vol.45 No.3
The aim of this study was to investigating whether lncRNA H19 promotes myocardial fibrosis by suppressing the miR-29a-3p/miR-29b-3p-VEGFA/TGF-β axis. Patients with atrial fibrillation (AF) and healthy volunteers were included in the study, and their biochemical parameters were collected. In addition, pcDNA3.1-H19, si-H19, and miR-29a/b-3p mimic/inhibitor were transfected into cardiac fibroblasts (CFs), and proliferation of CFs was detected by MTT assay. Expression of H19 and miR-29a/b-3p were detected using real-time quantitative polymerase chain reaction, and expression of α-smooth muscle actin (α-SMA), collagen I, collagen II, matrix metalloproteinase-2 (MMP-2), and elastin were measured by western blot analysis. The dual luciferase reporter gene assay was carried out to detect the sponging relationship between H19 and miR-29a/b-3p in CFs. Compared with healthy volunteers, the level of plasma H19 was significantly elevated in patients with AF, while miR-29a-3p and miR-29b-3p were markedly depressed (P < 0.05). Serum expression of lncRNA H19 was negatively correlated with the expression of miR-29a-3p and miR-29b-3p among patients with AF (rs = –0.337, rs = –0.236). Moreover, up-regulation of H19 expression and down-regulation of miR-29a/b-3p expression facilitated proliferation and synthesis of extracellular matrix (ECM)-related proteins. SB431542 and si-VEGFA are able to reverse the promotion of miR-29a/b-3p on proliferation of CFs and ECM-related protein synthesis. The findings of the present study suggest that H19 promoted CF proliferation and collagen synthesis by suppressing the miR-29a-3p/miR-29b-3p-VEGFA/TGF-β axis, and provide support for a potential new direction for the treatment of AF.
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