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        Effective Heterogeneous Ensemble Classification: An Alternative Approach for Selecting Base Classifiers

        Esra’a Alshdaifat,Malak Al-hassan,Ahmad Aloqaily 한국통신학회 2021 ICT Express Vol.7 No.3

        In this paper, an alternative approach to select base classifiers forming a parallel Heterogeneous ensemble is proposed. The fundamental concept is to trim poorly performing classifiers; thus, a more effective Heterogeneous ensemble can be generated. More specifically, the proposed trimming approach finds an optimal subset of classifiers to form the desired heterogeneous ensemble. The main challenge is how to detect poor performance classifiers. To address this issue, the differences in effectiveness between base classifiers forming the ensemble are utilized to spot weak classifiers. For evaluating the proposed approach, eighteen benchmark datasets are used for generating the heterogeneous ensemble classification and comparisons with the state-of-the-art methods are conducted. The experimental analysis demonstrated the effectiveness and superiority of the proposed approach when compared to other state-of-the-art approaches.

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        Association of single-nucleotide polymorphisms in the ESR2 and FSHR genes with poor ovarian response in infertile Jordanian women

        Amer Mahmoud Sindiani,Osamah Batiha,Esra’a Al-zoubi,Sara Khadrawi,Ghadeer Alsoukhni,Ayesha Alkofahi,Nour Alhoda Alahmad,Sherin Shaaban,Eman Alshdaifat,Masood Abu-Halima 대한생식의학회 2021 Clinical and Experimental Reproductive Medicine Vol.48 No.1

        Objective: Poor ovarian response (POR) refers to a subnormal follicular response that leads to a decrease in the quality and quantity of the eggs retrieved after ovarian stimulation during assisted reproductive treatment (ART). The present study investigated the associations of multiple variants of the estrogen receptor 2 (ESR2) and follicle-stimulating hormone receptor (FSHR) genes with POR in infertile Jordanian women undergoing ART.Methods: Four polymorphisms, namely ESR2 rs1256049, ESR2 rs4986938, FSHR rs6165, and FSHR rs6166, were investigated in 60 infertile Jordanian women undergoing ART (the case group) and 60 age-matched fertile women (the control group), with a mean age of 33.60±6.34 years. Single-nucleotide polymorphisms (SNPs) were detected by restriction fragment length polymorphism and then validated using Sanger sequencing.Results: The p-value of the difference between the case and control groups regarding FSHR rs6166 was very close to 0.05 (p=0.054). However, no significant differences were observed between the two groups in terms of the other three SNPs, namely ESR2 rs1256049, ESR2 rs4986938, and FSHR rs6165 (p=0.561, p=0.433, and p=0.696, respectively).Conclusion: The association between FSHR rs6166 and POR was not statistically meaningful in the present study, but the near-significant result of this experiment suggests that statistical significance might be found in a future study with a larger number of patients.

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