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Kerim Çayır,Ali Karadeniz,Nejdet Şimşek,Serap Yıldırım,Emre Karakuş,Adem Kara,Hürrem Turan Akkoyun,Emin Şengül 한국식품영양과학회 2011 Journal of medicinal food Vol.14 No.10
Cisplatin (CDDP), one of the most active cytotoxic agents against cancer, has adverse side effects, such as nephrotoxicity and hepatotoxicity. The present study was designed to investigate the potential protective effect of pomegranate seed extract (PSE) against oxidative stress caused by CDDP injury of the kidneys and liver by measuring tissue biochemical and antioxidant variables and immunohistochemically testing caspase-3–positive cells. Twenty-four Sprague–Dawley rats were divided into 4 groups: control; CDDP: injected intraperitoneally with CDDP (7 mg/kg body weight, single dose); PSE: treated for 15 consecutive days by gavage with PSE (300 mg/kg per day); and PSE+CDDP: treated by gavage with PSE 15 days after a single injection of CDDP. The degree of protection against CDDP injury afforded by PSE was evaluated by determining the levels of malondialdehyde as a measure of lipid peroxidation. The levels of glutathione and activities of glutathione peroxidase, glutathione S-transferase, and superoxide dismutase were estimated from liver and kidney homogenates; the liver and kidney were also histologically examined. PSE elicited a significant protective effect toward liver and kidney by decreasing the level of lipid peroxidation; elevating the levels of glutathione S-transferase; and increasing the activities of glutathione peroxidase, glutathione S-transferase, and superoxide dismutase. These biochemical observations were supported by immunohistochemical findings and suggested that PSE significantly attenuated nephrotoxicity and hepatotoxicity by the way of its antioxidant, radical-scavenging, and antiapoptotic effects. This PSE extract could be used as a dietary supplement in patients receiving chemotherapy medications.
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Murat Yaylacı,Bahar Şengül Şabano,Mehmet Emin Özdemir,Ahmet Birinci 국제구조공학회 2022 Structural Engineering and Mechanics, An Int'l Jou Vol.82 No.3
The aim of this study is to examine the frictionless double receding contact problem for two functionally graded (FG) layers pressed with a uniformly distributed load and resting on a homogeneous half plane (HP) using analytical and numerical methods. The FG layers are made of a non-homogeneous material with an isotropic stress-strain law with exponentially varying properties. It is assumed that the contact at the FG layers and FG layer-HP interface is frictionless. The body force of the FG layers and homogeneous HP are ignored in the study. Firstly, an analytical solution for the contact problem has been realized using the theory of elasticity and the Fourier integral transform techniques. Then, the problem modeled and two-dimensional analysis was carried out by using the ANSYS package program based on FEM. Numerical results for contact lengths and contact pressures between FG layers and FG layer-HP were provided for various dimensionless quantities including material inhomogeneity, distributed load width, the shear module ratio, and the heights of the FG layers for both methods. The results obtained using FEM were compared with the results found using the analytical formulation. It was found that the results obtained from analytical formulation were in perfect agreement with the FEM study.
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