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RISS 인기검색어
- 검색키워드
- 저자 : Eleiwa, Mona M.E. (검색결과 3 건)
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Naglaa Z. H. Eleiwa,Azza A. A. Galal,Reda M. Abd El‑Aziz,Eman M. Hussin 경희대학교 융합한의과학연구소 2018 Oriental Pharmacy and Experimental Medicine Vol.18 No.2
Male infertility is a common side effect of doxorubicin (DOX) that substantially impairs the quality of life of young cancer survivors. Therefore, the current work was designed to evaluate the possible antioxidant and gonado-protective effects of Spirulina platensis (S. platensis) in DOX-treated rats. Intraperitoneal administration of DOX (3 mg/kg b.wt.) once weekly for 5 weeks significantly decreased the levels of testicular catalase, superoxide dismutase and glutathione peroxidase. Moreover, it significantly decreased serum testosterone, luteinizing hormone, and follicle-stimulating hormone levels, as well as sperm motility and sperm count. Additionally, DOX treatment significantly increased the testicular malondialdehyde concentration and the percent of sperm abnormalities and resulted in marked cystic dilation of seminiferous tubules with extensive separation, dissociation of germinal cells from the basement membrane and arrested spermatogenesis. Oral administration of S. platensis at a dose of 300 mg/kg daily for 5 weeks mitigated DOX-induced oxidative stress, testicular damage, hormone alterations and spermiogram abnormalities via its potent antioxidant activity. S. platensis may represent a potential therapeutic option to protect testicular tissue during DOX treatment.
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Embryotoxic and Teratogenic Effects of Tartrazine in Rats
Hashem, Mohamed Mohammed,Abd-Elhakim, Yasmina Mohammed,Abo-EL-Sooud, Khaled,Eleiwa, Mona M.E. Korean Society of ToxicologyKorea Environmental Mu 2019 Toxicological Research Vol.35 No.1
Tartrazine (TAZ) is one of the most commonly used artificial dyes for foods and drugs. We determined the effect of TAZ on fetal development by examining morphological, visceral, and skeletal malformations in rat fetuses following daily oral administration of TAZ to pregnant Wistar rats at the 6th-15th day of gestation. TAZ at 0.45 and 4.5 mg/kg induced 6.0 and 7.1% fetal resorptions, as well as 10.0 and 10.5% fetal mortality, respectively. Fetal body weight and length were significantly lower in the groups treated with TAZ at 0.45 ($3.97{\pm}0.21g$ and $27.3{\pm}0.54mm$, respectively) and 4.5 mg/kg ($3.48{\pm}0.15g$ and $23.22{\pm}1.02mm$, respectively) than in the control group ($4.0{\pm}0.15g$ and $30.01{\pm}0.42mm$, respectively). TAZ at 0.45 and 4.5 mg/kg induced hepatic damage (20 and 33.3%, respectively), dark brown pigmentation due to hemosiderin in the splenic parenchyma (16.7 and 21.7%, respectively), as well as destructed and necrotic renal tubules (16.7 and 26.7%, respectively) in the fetuses. Moreover, TAZ at 0.45 and 4.5 mg/kg caused one or more missing coccygeal vertebrae (20 and 40%, respectively), missing sternebrae (6 and 10%, respectively), missing hind limbs (24 and 4%, respectively), and irregular ribs (16 and 20, respectively) in the fetuses. We concluded that TAZ has embryotoxic and teratogenic potentials in rats.
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Embryotoxic and Teratogenic Effects of Tartrazine in Rats
Mohamed Mohammed Hashem,Yasmina Mohammed Abd-Elhakim,Khaled Abo-EL-Sooud,Mona M. E. Eleiwa 한국독성학회 2019 Toxicological Research Vol.35 No.1
Tartrazine (TAZ) is one of the most commonly used artificial dyes for foods and drugs. We determined the effect of TAZ on fetal development by examining morphological, visceral, and skeletal malformations in rat fetuses following daily oral administration of TAZ to pregnant Wistar rats at the 6th-15th day of gestation. TAZ at 0.45 and 4.5 mg/kg induced 6.0 and 7.1% fetal resorptions, as well as 10.0 and 10.5% fetal mortality, respectively. Fetal body weight and length were significantly lower in the groups treated with TAZ at 0.45 (3.97 ± 0.21 g and 27.3 ± 0.54 mm, respectively) and 4.5 mg/kg (3.48 ± 0.15 g and 23.22 ± 1.02 mm, respectively) than in the control group (4.0 ± 0.15 g and 30.01 ± 0.42 mm, respectively). TAZ at 0.45 and 4.5 mg/kg induced hepatic damage (20 and 33.3%, respectively), dark brown pigmentation due to hemosiderin in the splenic parenchyma (16.7 and 21.7%, respectively), as well as destructed and necrotic renal tubules (16.7 and 26.7%, respectively) in the fetuses. Moreover, TAZ at 0.45 and 4.5 mg/kg caused one or more missing coccygeal vertebrae (20 and 40%, respectively), missing sternebrae (6 and 10%, respectively), missing hind limbs (24 and 4%, espectively), and irregular ribs (16 and 20, respectively) in the fetuses. We concluded that TAZ has embryotoxic and teratogenic potentials in rats.
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