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RISS 인기검색어
- 검색키워드
- 저자 : Elahe Taghiabadi (검색결과 4 건)
- 무료
- 기관 내 무료
- 유료
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Effect of Aqueous and Ethanolic Extracts of Nigella sativa Seeds on Milk Production in Rats
Hossein Hosseinzadeh,Mohsen Tafaghodi,Mojdeh Jalal Mosavi,Elahe Taghiabadi 사단법인약침학회 2013 Journal of Acupuncture & Meridian Studies Vol.6 No.1
Nigella sativa L. is used as a galactagogue in traditional medicine. Hence, the effects of aqueous and ethanolic extracts of N. sativa seeds on milk production in rats were evaluated. The measurement of milk production was by measuring pup weight during suckling period. The intraperitoneal LD50 values of aqueous and ethanolic extracts of N. sativa were 4.23 and 4.9 g/kg, respectively. The aqueous (0.5 g/kg) and ethanolic extracts (1 g/kg) increased milk production significantly (p < 0.001), producing about 31.3% and 37.6% more milk than control, respectively. During the study period, the pups gained weight with the aqueous (0.5 g/kg, p < 0.01) and ethanolic extracts (1 g/kg,p < 0.05). It is concluded that aqueous and ethanolic extracts of N. sativa can stimulate milk production in rats.
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Javad Behravan,Fatemeh Mosafa,Negar Soudmand,Elahe Taghiabadi,Bibi Marjan Razavi,Gholamreza Karimi 사단법인약침학회 2011 Journal of Acupuncture & Meridian Studies Vol.4 No.3
The comet assay is a standard method for measuring DNA damage. In this study, the protective effects of ethanolic and aqueous extracts of Portulaca oleracea L. (P. oleracea)on human lymphocyte DNA lesions were evaluated with the comet assay. Lymphocytes were isolated from blood samples taken from healthy volunteers. Human lymphocytes were incubated in H_2O_2 (50,100, and 200 mM), aqueous extract (0.05, 0.1,0.5, 1, and 2.5 mg/ml), and ethanolic extracts (0.05, 0.1, 0.5, 1, and 2.5 mg/ml) of P. oleraceae aerial parts alone with a combination of H_2O_2 (100 mM) with either 1 or 2.5 mg/ml of both extracts at 4℃ for 30 minutes. The extent of DNA migration was measured using the alkaline single cell gel electrophoresis approach assay, and DNA damage was expressed as percentage tail DNA. We found that the aqueous extract of P. oleracea significantly inhibited DNA damage, while there was no effect of the ethanolic extract. These data suggest that the aqueous extract of P. oleracea can prevent oxidative DNA damage to human lymphocytes, which is likely due to antioxidant constituents in the extract.
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Anticonvulsant Effect of Berberis integerrima L. Root Extracts in Mice
Hossein Hosseinzadeh,Mohammad Ramezani,Hojjat Shafaei,Elahe Taghiabadi 사단법인약침학회 2013 Journal of Acupuncture & Meridian Studies Vol.6 No.1
Berberis integerrima is a member of Berberidaceae family. Berberine is one of the main constituents of this plant, having neuroprotective effect on central nervous system diseases. In this study, the anticonvulsant activity of methanolic extract, and hydromethanolic fraction, and chloroform fraction of B integerrima was assessed. The anticonvulsant effect of B integerrima was investigated using both pentylenetetrazole (PTZ) and maximal electroshock (MES)-induced seizure models. The LD50 value of the methanolic extract was 302.676 mg/kg. In the PTZ test, methanolic extract (140 and 200 mg/kg,i.p., p < 0.01), hydromethanolic fraction (200 mg/kg, p < 0.01), and chloroform fraction (200 mg/kg, p < 0.01) increased the onset time of hind limb tonic extensions (HLTEs). The protective effect against mortality (convulsion survivors/animals tested) was 2/8 in methanolic extract, and 3/8 in hydromethanolic fraction at a dose of 200 mg/kg and in chloroform fraction at a dose of 140 mg/kg. In the MES test, this plant did not display any significant effect in reducing HLTE duration. According to phytochemical screening,methanolic extract contained alkaloids and tannins. The present study, conducted in mice, indicated that B integerrima has anticonvulsant activity in PTZ-induced seizures. It is concluded that B integerrima may be useful in petit mal epilepsy.
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Effect of Aqueous and Ethanolic Extracts of Pimpinella anisum L. Seeds on Milk Production in Rats
Hossein Hosseinzadeh,Mohsen Tafaghodi,Shirin Abedzadeh,Elahe Taghiabadi 사단법인약침학회 2014 Journal of Acupuncture & Meridian Studies Vol.7 No.4
Pimpinella anisum L. (P. anisum) is used as a galactagogue in traditional medicine; hence, the effect of aqueous and ethanolic extracts of P. anisum seeds on milk production in rats was evaluated. The milk production was assessed by measuring the pups’ weights during the suckling period. The intraperitoneal LD 50 values of P. anisum aqueous and ethanolic extracts were 4.93 and 3.77 g/kg, respectively. The aqueous (1 g/kg) and ethanolic ex- tracts (1 g/kg) increased the milk production significantly (p < 0.001), with about 68.1% and 81% more milk being produced, respectively, than in the control group. The pups gained weight during the study period with the aqueous (0.5 and 1 g/kg, p < 0.05) and ethanolic (0.5 and 1 g/kg, p < 0.01) extracts. Thus, P. anisum aqueous and ethanolic extracts can increase milk production in rats.
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