Electro-acupuncture Stimulation at Acupoints Reduced the Severity of Hypotension During Anesthesia in Patients Undergoing Liver Transplantation

Mohammad Hossein Eghbal,Mohammad Ali Sahmeddini,Mohammad Bagher Khosravi,Sina Ghaffaripour,Farahzad Janatmakan,Sakine Shokrizade 사단법인약침학회 2012 Journal of Acupuncture & Meridian Studies Vol.5 No.1

Background: Patients with end-stage liver diseases who undergo liver transplantation may suffer from hypotension related to the liver disease itself or related to the surgical procedure. Because electro-acupuncture (EA) at the Neiguan (PC-6) and the Jianshi (PC-5) points influences hemodynamics,we hypothesize that electro-acupuncture at the traditionally used acupuncture points will reduce the severity of hypotension in patients who undergo liver transplantation. Methods: Forty patients with end-stage liver disease who underwent orthotropic deceased donor liver transplantation were randomized into two groups. The norepinephrine (NE) group received norepinephrine as a vasoconstrictor, and the electro-acupuncture group received EA at the PC-5and the PC-6 points for treatment of hypotension during anesthesia for the liver transplantation. The patients were monitored, during the three stages of liver transplantation by using hemodynamic parameters. Results: During the three stages of liver transplantation, there were no significant differences in the hemodynamic measurements including the mean arterial pressure, heart rate and central venous pressure between the two groups (p > 0.05). Conclusions: Electro-acupuncture at the acupuncture points reduced the severity and the incidence of hypotension during anesthesia for liver transplantation.

Surgical management of a failed internal root resorption treatment: a histological and clinical

Asgary, Saeed,Eghbal, Mohammad Jafar,Mehrdad, Leili,Kheirieh, Sanam,Nosrat, Ali The Korean Academy of Conservative Dentistry 2014 Restorative Dentistry & Endodontics Vol.39 No.2

This article presents the successful surgical management of a failed mineral trioxide aggregate (MTA) orthograde obturation of a tooth with a history of impact trauma and perforated internal root resorption. A symptomatic maxillary lateral incisor with a history of perforation due to internal root resorption and nonsurgical repair using MTA was referred. Unintentional overfill of the defect with MTA had occurred 4 yr before the initial visit. The excess MTA had since disappeared, and a radiolucent lesion adjacent to the perforation site was evident radiographically. Surgical endodontic retreatment was performed using calcium enriched mixture (CEM) cement as a repair material. Histological examination of the lesion revealed granulation tissue with chronic inflammation, and small fragments of MTA encapsulated within fibroconnective tissue. At the one and two year follow up exams, all signs and symptoms of disease had resolved and the tooth was functional. Complete radiographic healing of the lesion was observed two years after the initial visit. This case report illustrates how the selection of an appropriate approach to treatment of a perforation can affect the long term prognosis of a tooth. In addition, extrusion of MTA into a periradicular lesion should be avoided.

Surgical management of a failed internal root resorption treatment: a histological and clinical report

Saeed Asgary,Mohammad Jafar Eghbal,Leili Mehrdad,Sanam Kheirieh,Ali Nosrat 대한치과보존학회 2014 Restorative Dentistry & Endodontics Vol.39 No.2

This article presents the successful surgical management of a failed mineral trioxide aggregate (MTA) orthograde obturation of a tooth with a history of impact trauma and perforated internal root resorption. A symptomatic maxillary lateral incisor with a history of perforation due to internal root resorption and nonsurgical repair using MTA was referred. Unintentional overfill of the defect with MTA had occurred 4 yr before the initial visit. The excess MTA had since disappeared, and a radiolucent lesion adjacent to the perforation site was evident radiographically. Surgical endodontic retreatment was performed using calcium enriched mixture (CEM) cement as a repair material. Histological examination of the lesion revealed granulation tissue with chronic inflammation, and small fragments of MTA encapsulated within fibroconnective tissue. At the one and two year follow up exams, all signs and symptoms of disease had resolved and the tooth was functional. Complete radiographic healing of the lesion was observed two years after the initial visit. This case report illustrates how the selection of an appropriate approach to treatment of a perforation can affect the long term prognosis of a tooth. In addition, extrusion of MTA into a periradicular lesion should be avoided.

Assessing the Effects of Deforestation and Reforestation on Soil Carbon Dynamics and 14c Dating

Ebrahim Moghiseh,Ahmad Heidari,Mohammad Ghannadi,Hassan Tofighi,Fereydoon Sarmadian,Mostafa Karimian Eghbal,Nejat Pirvali,Sadollah Teimouri,Ali Khorasani 한국토양비료학회 2014 한국토양비료학회 학술발표회 초록집 Vol.2014 No.6

Correlates of Lymphedema in Women with Breast Cancer: a Case Control Study in Shiraz, Southern Iran

Honarvar, Behnam,Sayar, Negin,Tahmasebi, Sedigheh,Zakeri, Zeinab,Talei, Asra,Rostami, Sara,Khademi, Sahar,Sarvestani, Amene Sabzi,Sekhavati, Eghbal Asian Pacific Journal of Cancer Prevention 2016 Asian Pacific journal of cancer prevention Vol.17 No.no.sup3

Globally, the burden of breast cancer (BC) continues to increase. BC related lymphedema (BCRL) is currently non curable and as a life time risk it affects at least 25% of BC patients. Knowing more about BCRL and appropriate control of its modifiable risk factors can improve quality of life (QOL) of the affected patients. In this case control study to detect factors, 400 women with BCRL (as the case group) and 283 patients with BC without lymphedema (as the control group) that were referred to Shiraz University of Medical Sciences affiliated BC clinic center were assessed. The data were analyzed in SPSS. The mean age of the case group was $52.3{\pm}11.0years$ and of the control group was $50.1{\pm}10.9years$. In patients with BCRL, 203(50.7%) had left (Lt) side BC and in non- lymphedema group 151 (53.3%) had Lt side BC. Out of all BCRL patients, 204 (51%) had lymphedema in all parts of their affected upper extremities, 100 (25%) had swelling in the arm and forearm and 23 (5.7%) had edema in both the upper extremity and trunk. Edema, heaviness, concern about changing body image, pain and paresthesia were the most common signs/symptoms among patients with BCRL. In BCRL patients, the difference of circumference between the affected upper limb and non-affected limb was $4.4{\pm}2.5cm$ and the difference in volume displacement was $528.7{\pm}374.4milliliters$. Multiple variable analysis showed that moderate to severe activity (OR; odds ratio =14, 95% CI :2.6-73.3), invasiveness of BC (OR =13.7, 95% CI :7.3-25.6), modified radical mastectomy (OR=4.3, 95% CI :2.3-7.9), BMI =>25 (OR=4.2, 95% CI :2-8.7), radiotherapy (OR=3.9, 95% CI :1.8-8.2), past history of limb damage (OR=1.7, 95% CI :0.9-3.1) and the number of excised lymph nodes (OR=1.06, 95% CI :1.02-1.09) were the significant predictors of lymphedema in women with BC. Modifiable risk factors of BCRL such as non-guided moderate to severe physical activity, high BMI and trauma to the limb should be controlled as early as possible in BC patients to prevent development of BCRL and improve QOL of these patients.

In vitro and in vivo evaluation of the mechanisms of citalopraminduced hepatotoxicity

Elham Ahmadian,Aziz Eftekhari,Javad Khalili Fard,Hossein Babaei,Alireza Mohajjel Nayebi,Daryoush Mohammadnejad,Mohammad Ali Eghbal 대한약학회 2017 Archives of Pharmacal Research Vol.40 No.11

Even though citalopram is commonly used inpsychiatry, there are several reports on its toxic effects. So,the current study was designed to elucidate the mechanismsof cytotoxic effects of in vitro and in vivo citalopramtreatment on liver and the following cytolethal events. Forin vitro experiments, freshly isolated rat hepatocytes wereexposed to citalopram along with/without various agents. To do in vivo studies liver function enzyme assays andhistological examination were performed. In the in vitroexperiments, citalopram (500 lM) exposure demonstratedcell death, a marked elevation in ROS formation, mitochondrialpotential collapse, lysosomal membrane leakiness,glutathione (GSH) depletion and lipid peroxidation. In vivo biochemistry panel assays for liver enzymesfunction (AST, ALT and GGTP) and histological examinationconfirmed citalopram (20 mg/kg)-induced damage. citalopram-induced oxidative stress cytotoxicity markerswere significantly prevented by antioxidants, ROS scavengers,MPT pore sealing agents, endocytosis inhibitors,ATP generators and CYP inhibitors. Either enzymeinduction or GSH depletion were concomitant with augmentedcitalopram-induced damage both in vivo andin vitro which were considerably ameliorated withantioxidants and CYP inhibitors. In conclusion, it is suggestedthat citalopram hepatotoxicity might be a result ofoxidative hazard leading to mitochondrial/lysosomal toxicconnection and disorders in biochemical markers whichwere supported by histomorphological studies.

Relationship between Urbanization and Cancer Incidence in Iran Using Quantile Regression

Momenyan, Somayeh,Sadeghifar, Majid,Sarvi, Fatemeh,Khodadost, Mahmoud,Mosavi-Jarrahi, Alireza,Ghaffari, Mohammad Ebrahim,Sekhavati, Eghbal Asian Pacific Journal of Cancer Prevention 2016 Asian Pacific journal of cancer prevention Vol.17 No.no.sup3

Quantile regression is an efficient method for predicting and estimating the relationship between explanatory variables and percentile points of the response distribution, particularly for extreme percentiles of the distribution. To study the relationship between urbanization and cancer morbidity, we here applied quantile regression. This cross-sectional study was conducted for 9 cancers in 345 cities in 2007 in Iran. Data were obtained from the Ministry of Health and Medical Education and the relationship between urbanization and cancer morbidity was investigated using quantile regression and least square regression. Fitting models were compared using AIC criteria. R (3.0.1) software and the Quantreg package were used for statistical analysis. With the quantile regression model all percentiles for breast, colorectal, prostate, lung and pancreas cancers demonstrated increasing incidence rate with urbanization. The maximum increase for breast cancer was in the 90th percentile (${\beta}$=0.13, p-value<0.001), for colorectal cancer was in the 75th percentile (${\beta}$=0.048, p-value<0.001), for prostate cancer the 95th percentile (${\beta}$=0.55, p-value<0.001), for lung cancer was in 95th percentile (${\beta}$=0.52, p-value=0.006), for pancreas cancer was in 10th percentile (${\beta}$=0.011, p-value<0.001). For gastric, esophageal and skin cancers, with increasing urbanization, the incidence rate was decreased. The maximum decrease for gastric cancer was in the 90th percentile(${\beta}$=0.003, p-value<0.001), for esophageal cancer the 95th (${\beta}$=0.04, p-value=0.4) and for skin cancer also the 95th (${\beta}$=0.145, p-value=0.071). The AIC showed that for upper percentiles, the fitting of quantile regression was better than least square regression. According to the results of this study, the significant impact of urbanization on cancer morbidity requirs more effort and planning by policymakers and administrators in order to reduce risk factors such as pollution in urban areas and ensure proper nutrition recommendations are made.