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- 저자 : Dong Chaochao (검색결과 2 건)
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Wang Shumin,Dong Kaiye,Zhang Ji,Chen Chaochao,Shuai Hongyan,Yu Xin 한국영양학회 2023 Nutrition Research and Practice Vol.17 No.6
BACKGROUND/OBJECTIVES: Inonotus obliquus has been used as antidiabetic herb around the world, especially in the Russian and Scandinavian countries. Diabetes is widely believed to be a key factor in Alzheimer’s disease (AD), which is widely considered to be type III diabetes. To investigate whether I. obliquus can also ameliorate AD, it would be interesting to identify new clues for AD treatment. We tested the anti-AD effects of raw Inonotus obliquus polysaccharide (IOP) in a mouse model of AD (3×Tg-AD transgenic mice). MATERIALS/METHODS: SPF-grade 3×Tg-AD mice were randomly divided into three groups (Control, Metformin, and raw IOP groups, n = 5 per group). β-Amyloid deposition in the brain was analyzed using immunohistochemistry for AD characterization. Gene and protein expression of pertinent factors of the ubiquitin-proteasome system (UPS) was determined using real-time quantitative polymerase chain reaction and Western blotting. RESULTS: Raw IOP significantly reduced the accumulation of amyloid aggregates and facilitated UPS activity, resulting in a significant reduction in AD-related symptoms in an AD mouse model. The presence of raw IOP significantly enhanced the expression of ubiquitin, E1, and Parkin (E3) at both the mRNA and protein levels in the mouse hippocampus. The mRNA level of ubiquitin carboxyl-terminal hydrolase isozyme L1, a key factor involved in UPS activation, also increased by approximately 50%. CONCLUSIONS: Raw IOP could contribute to AD amelioration via the UPS pathway, which could be considered as a new potential strategy for AD treatment, although we could not exclude other mechanisms involved in counteracting AD processing.
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Cao Miaomiao,Shao Zhiyu,Wu Siyu,Dong Chaochao,Yang Xiaotian 대한조선학회 2021 International Journal of Naval Architecture and Oc Vol.13 No.1
The water entry behaviors of projectiles with different cone-headed angles were studied numerically, experimentally and theoretically, mainly focusing on the hydrodynamic impact in the initial stage. Based on MMALE algorithm, it was proposed a formula of impact deceleration, which relied on the initial entry velocity and cone-headed angle. Meanwhile, in order to verify the validity of the simulation model, experiments using accelerometer and high-speed camera were carried out, and their results were in a good agreement with simulation results. Also, theoretical calculation results of cavity diameter were compared with experiments and simulation results. It was observed that the simulation method had a good reliability, which would make forecast on impact deceleration in an engineering project.
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