http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
- 中文 을 입력하시려면 zhongwen을 입력하시고 space를누르시면됩니다.
- 北京 을 입력하시려면 beijing을 입력하시고 space를 누르시면 됩니다.
RISS 인기검색어
- 검색키워드
- 저자 : Dhruba Acharya (검색결과 4 건)
- 무료
- 기관 내 무료
- 유료
-
( Dhruba Acharya ),( Bikash Bogati ) 대한내과학회 2014 대한내과학회 추계학술대회 Vol.2014 No.1
Background: The role of TORCH infections as a cause of bad obstetric outcomes is still debatable with con. icting Results: Even though, the demonstration of seroconversion in the patient sera in vitro is a highly established method to predict bad obstetric outcomes. However, it is our impression that the TORCH test has not been optimally used in hospital settings in Nepal. Methods: This descriptive case control study was undertaken (January 2012 to December, 2013) to discover the association of TORCH infections in women with bad obstetric history by serological testing. A serological evaluation was carried out to determine the presence of Toxoplasma gondii, Rubella, Cytomegalovirus (CMV) and Herpes Simplex Virus (HSV) speci. c immunoglobulin G (IgG) and immunoglobulin M (IgM) antibodies, using ELISA technique. Results: Mean age of the study and control subjects were 27. 8+/-5. 4 and 25. 3+/- 2. 8 years, respectively where majority of the study subjects were of the age between 20 to 35 years. Most of the cases were of spontaneous abortions (81%) followed by IUGR (9%). Only 0. 9% of both IgG and IgM seropositivity against TORCH agents were noted among the study subjects whereas highest IgG seropositivity was detected with Rubella (76. 8%) followed by HSV-I (71. 8%). An infection susceptibility rate of 75. 9% to Toxoplasma gondii, 9. 2% to Rubella, 41. 2% to CMV, 21. 4% to HSV-I and 72. 1% to HSV-II was noted. Conclusions: Two possible results might be concluded from our study. first, acute infection of TORCH agents might not be the only possible etiology of bad obstetric outcome and secondly, serological TORCH screening may not be conclusive. This study, probably the . rst of its kind from Nepal, suggests that TORCH test is questionable for its reliability.
-
( Prabodh Risal ),( Dhruba Acharya ),( Prabin Gyawali ),( Meera Hada ) 대한간학회 2013 춘·추계 학술대회 (KASL) Vol.2013 No.1
Background and Methods: Medical complications in intestinal parasitic infection include diarrhea, anemia and malnutrition. Another important problem is human parasites decreases the secretion of immunoglobulinA (IgA), resulting in increased risk of viral infection including hepatitis. There are many reports on co-infection by intestinal parasites and worms among HIV-infected patients, but the parasitic infection among viral hepatitis has not been studied so far in Nepal. There are some experts considering parasitic infections to be the missing diagnosis in many acute and chronic health problems including hepatitis. We conducted this study to evaluate the frequency of common intestinal parasites among viral hepatitis patients in Kathmandu University Hospital. 289 patients diagnosed as viral hepatitis during the period of August 2012 to April 2013 in Kathmandu University Hospital were enrolled in the study. Blood samples and stool samples were analyzed to see the frequency of co-infection and the association between the presence of parasites in their stools and the level of serum Billirubin, Aspartate Transaminase (AST), Alanine transaminase (ALT), and Alkaline phosphatase (ALP). Results: The laboratory results showed significantly higher prevalence of intestinal parasite among the patients with viral hepatitis compared to the control group. The most common parasite infection was Entamoeba coli, followed by E. histolytica, Trichuris trichuria, Giardia lamblia, Ascaris lumbricoides and hookworm. Among the total positive cases around 30% had multiple parasitic infections. Serum AST and ALT was higher in the patients with intestinal parasitic infection where as serum bilirubin and ALP were not different among the control and viral hepatitis groups. Conclusions: In conclusion, higher prevalence of intestinal parasitic infection was seen in the patients with viral hepatitis, resulting in a more severe disease outcome.
-
Liver Hydroxylation of Vitamin D and Its Relationship to Autoimmune Thyroid Disease
( Mukunda Raj Kalouni ),( Bhup Dev Bhatta ),( Dhruba Acharya ) 대한간학회 2017 춘·추계 학술대회 (KASL) Vol.2017 No.1
Aims: 25 hydroxy vitamin D is synthesized in the liver by microsomal enzyme 25-hydroxylase. Vitamin D is associated with autoimmune thyroid disease. Recently its role in the immune modulator has been discovered. The aim of the study was to evaluate the relationship between 25 hydroxy vitamin D and thyroperoxidase (TPO) antibody. Methods: 200 subjects were enrolled in this study, among them 100 were study group and 100 were healthy control group during june 2014 to may 2016. Serum levels of anti TPO antibody, 25 hydroxy vitamin D, thyroid stimulating hormone, free thyroxine and free tri-iodothyronine were measured by chemiluminiscence immuno assay (CLIA, maglumi 1000) Results: We found a statistically significant correlation between 25 hydroxy vitamin D and thyroperoxidase antibody (p= <0.001). Study group had lower levels of vitamin D than control group 21.86 ± 8.41 and 32.27 ± 11.75 respectively.( p= <0.001). Serum 25 hydroxy vitamin D was inversely correlated with antithyroperoxidase antibody (r = -0.318, p= < 0.001). Study group had higher TPO antibody levels as compared to control group. Conclusions: Our study suggests that vitamin D deficiency was significantly associated with autoimmune thyroid disease. It also found that patients with autoimmune thyroid disease had lower levels of 25 hydroxy vitamin D. We also found a negative correlation between TPO antibody and Vitamin D.
-
The fate of hepatocyte cell line derived from a liver injury model with long-term in vitro passage
Lokendra Chand,Prabodh Risal,Nirajan Shrestha,Dhruba Acharya,Yae Sul Jeong,Chan-Young Kim,Yeon Jun Jeong 대한독성 유전단백체 학회 2018 Molecular & cellular toxicology Vol.14 No.3
Backgrounds: Orthotopic Liver Transplantation (OLT) is the therapy of choice for the treatment of end-stage liver disease, but the severe shortage of organ donors, complex and expensive surgical procedure and increased mortality of prospective organ recipient limit the use of OLT. To overcome this problem the technique of hepatocyte transplantation has been considered as an alternative to OLT. Hepatocyte transplantation is less invasive, cost effective cryo-preservable and can be distributed from single donor to multiple recipients. In this study we have established and characterize the hepatocyte cell line possessing the morphological and functional characteristics of hepatocytes from chemically injured liver. Hence we hypothesized that the hepatocyte cell line derived from liver injury can be used for hepatocyte transplantation. Methods: To induce the priming of hepatocyte, mice were fed with 3,5-diethoxycarbonyl-1,4-dihydro-collidine (DDC) diet for 3 weeks and hepatocytes were obtained by two step collagenase perfusion method, hepatocytes hence obtained was expended by >300 passages and tested for various hepatocyte specific functions. Results: The cell line derived from liver injury model retains morphological and functional characteristics of hepatocytes in long-term in vitro culture. These cells transplanted to mice showed significant survival rate. Conclusion: The Hepatocyte cell line derived from liver injury model were used for hepatocyte transplantation and showed the significantly higher survival rate.
연관 검색어 추천
이 검색어로 많이 본 자료
활용도 높은 자료
