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Critical Role for CD38-mediated Ca2+ Signaling in Thrombin-induced Procoagulant Activity of Mouse Platelets and Hemostasis
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단일전구체를 이용한 SiC 나노로드의 성장
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유육종증의 초기에 발견된 동창루푸스
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Hysterectomy - a life-saving as well as a life-enhancing operation?
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Wit-Rusland: dictatuur en legitimiteit tussen Rusland en Europa
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Beyond 'Pluralism'
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- 저자 : Del R Millan, Jose (검색결과 4 건)
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( Octavio Godinez ),( Paul Dyson ),( Ricardo Del Sol ),( Javier Barrios Gonzalez ),( Cesar Millan Pacheco ),( Armando Mejia ) 한국미생물 · 생명공학회 2015 Journal of microbiology and biotechnology Vol.25 No.11
The transition from primary to secondary metabolism in antibiotic-producing Streptomyces correlates with expression of genes involved in stress responses. Consequently, regulatory pathways that regulate specific stress responses are potential targets to manipulate to increase antibiotic titers. In this study, genes encoding key proteins involved in regulation of the osmotic stress response in Streptomyces avermitilis, the industrial producer of avermectins, are investigated as targets. Disruption of either osaBSa, encoding a response regulator protein, or osaCSa, encoding a multidomain regulator of the alternative sigma factor SigB, led to increased production of both oligomycin, by up to 200%, and avermectin, by up to 37%. The mutations also conditionally affected morphological development; under osmotic stress, the mutants were unable to erect an aerial mycelium. In addition, we demonstrate the delivery of DNA into a streptomycete using biolistics. The data reveal that information on stress regulatory responses can be integrated in rational strain improvement to improve yields of bioactive secondary metabolites.
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Julio Gir?-Calle,Javier Vioque,Maria del Mar Yust,Justo Pedroche,Manuel Alaiz,Francisco Millan 한국식품영양과학회 2004 Journal of medicinal food Vol.7 No.2
Pulses should be part of a healthy diet, and it is also becoming clear that they have health-promoting effects. Nevertheless, most studies on the bioactive or health-promoting properties of pulses have been carried out using soybeans. We have studied cell growth-regulating properties, which may be responsible for anti-cancer properties, in chickpea seeds. Chickpea seeds are a staple in the traditional diet of many Mediterranean, Asian, and South and Central American countries. In addition, chickpea seeds have industrial applications since they can be used for the preparation of protein concentrates and isolates. The cell lines Caco-2 (epithelial intestinal) and J774 (macrophages) have been exposed to chickpea seed extracts and protein preparations in order to screen the different chickpea fractions for effects on cell growth. Both cell growth-promoting and cell growth-inhibiting effects were found. Most interestingly, a fraction soluble in ethanol and acetone specifically and almost completely inhibited the growth of Caco-2 cells exhibiting a cancerous phenotype. It is concluded that chickpea seeds are a source of bioactive components and deserve further study for their possible anti-cancer effect.
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Comparison of physicochemical properties of bio and commercial hydroxyapatite
A.L. Giraldo-Betancur,D.G. Espinosa-Arbelaez,A. del Real-López,B.M. Millan-Malo,E.M. Rivera-Muñoz,E. Gutierrez-Cortez,P. Pineda-Gomez,S. Jimenez-Sandoval,M.E. Rodriguez-García 한국물리학회 2013 Current Applied Physics Vol.13 No.7
This article reports a physicochemical comparison of synthetic and biological Hydroxyapatite (HAp). Eight samples were separated into two groups: bio and commercial hydroxyapatite (bio-HAp and commercial-HAp). The bio-HAp group containing defat, alkaline, and calcined samples taken from bovine bone were obtained by using three different treatments, in order to establish their effect on the final product quality. The commercial-HAp group, from different sources: NIST, sigma, apafill G, coralina, and biograft, were analyzed and compared with the bio-HAp results. Thermogravimetric analysis (TG) was used in order to establish thermal degradation of the samples; structural behavior was then analyzed by X-Ray Diffraction (XRD) to found the crystalline phases, as well as the crystalline quality. Fourier Transform Infrared Spectroscopy (FTIR) was performed in order to identify the corresponding HAp functional groups within the samples. The surface morphology was analyzed by Scanning Electron Microscopy (SEM) and the elemental composition was established by using Inductively Coupled Plasma Optical Emission Spectroscopy (ICP-OES). It was found that the calcination process obtains HAp with comparable quality to the commercial samples. A crystallinity greater than 62% after the alkaline process was found. Additionally, the surface of the alkaline sample presents a transition behavior between dense and porous morphology.
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Muller-Putz, Gernot,Leeb, Robert,Tangermann, Michael,Hohne, Johannes,Kubler, Andrea,Cincotti, Febo,Mattia, Donatella,Rupp, Rudiger,Muller, Klaus-Robert,Del R Millan, Jose IEEE 2015 Proceedings of the Institute of Electrical and Ele Vol.103 No.6
<P>In their early days, brain-computer interfaces (BCIs) were only considered as control channel for end users with severe motor impairments such as people in the locked-in state. But, thanks to the multidisciplinary progress achieved over the last decade, the range of BCI applications has been substantially enlarged. Indeed, today BCI technology cannot only translate brain signals directly into control signals, but also can combine such kind of artificial output with a natural muscle-based output. Thus, the integration of multiple biological signals for real-time interaction holds the promise to enhance a much larger population than originally thought end users with preserved residual functions who could benefit from new generations of assistive technologies. A BCI system that combines a BCI with other physiological or technical signals is known as hybrid BCI (hBCI). In this work, we review the work of a large scale integrated project funded by the European commission which was dedicated to develop practical hybrid BCIs and introduce them in various fields of applications. This article presents an hBCI framework, which was used in studies with nonimpaired as well as end users with motor impairments.</P>
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