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- 저자 : Daniel E. Singer (검색결과 2 건)
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E. Mitchell Seymour,Andrew A.M. Singer,Ara Kirakosyan,Daniel E. Urcuyo-Llanes,Peter B. Kaufman,Steven F. Bolling 한국식품영양과학회 2008 Journal of medicinal food Vol.11 No.2
Elevated plasma lipids, glucose, insulin, and fatty liver are among components of metabolic syndrome, a phe-notypic pattern that typically precedes the development of Type 2 diabetes. Animal studies show that intake of anthocyaninsreduces hyperlipidemia, obesity, and atherosclerosis and that anthocyanin-rich extracts may exert these effects in associationwith altered activity of tissue peroxisome proliferator-activated receptors (PPARs). However, studies are lacking to test thiscorrelation using physiologically relevant, whole food sources of anthocyanins. Tart cherries are a rich source of anthocyanins,and whole cherry fruit intake may also affect hyperlipidemia and/or affect tissue PPARs. This hypothesis was tested in theDahl Salt-Sensitive rat having insulin resistance and hyperlipidemia. For 90 days, Dahl rats were pair-fed AIN-76a-based di-ets supplemented with either 1% (wt:wt) freeze-dried whole tart cherry or with 0.85% additional carbohydrate to matchmacronutrient and calorie provision. After 90 days, the cherry-enriched diet was associated with reduced fasting blood glu-cose, hyperlipidemia, hyperinsulinemia, and reduced fatty liver. The cherry diet was also associated with significantly en-hanced hepatic PPAR-. mRNA, enhanced hepatic PPAR-. target acyl-coenzyme A oxidase mRNA and activity, and in-creased plasma antioxidant capacity. In conclusion, physiologically relevant tart cherry consumption reduced several phenotypicrisk factors that are associated with risk for metabolic syndrome and Type 2 diabetes. Tart cherries may represent a wholefood research model of the health effects of anthocyanin-rich foods and may possess nutraceutical value against risk factorsfor metabolic syndrome and its clinical sequelae.
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Chia-Yu Hsu,Daniel E. Singer,Hooman Kamel,Yi-Ling Wu,Pei-Chun Chen,Jiann-Der Lee,Meng Lee,Bruce Ovbiagele 대한뇌졸중학회 2019 Journal of stroke Vol.21 No.2
Background and Purpose Preceding episodes of paroxysmal atrial fibrillation (AF) among stroke patients can be easily overlooked in routine clinical practice. We aim to determine whether an unrecognized history of paroxysmal AF is associated with an increased risk of recurrent stroke. Methods We retrospectively identified all adult patients hospitalized with a primary diagnosis of ischemic stroke who had no AF diagnosis on their discharge records, using the Taiwan National Health Insurance Research Database between January 2001 and December 2012. Patients were categorized into two groups: unrecognized AF history and no AF. Patients with unrecognized AF history were defined as having documented AF preceding the index ischemic stroke hospitalization, but not recording at the index ischemic stroke. Primary endpoint was recurrent stroke within 1 year after the index stroke. Results Among 203,489 hospitalized ischemic stroke patients without AF diagnosed at discharge, 6,731 patients (3.3%) had an unrecognized history of prior transient AF. Patients with an unrecognized AF history, comparing to those without AF, had higher adjusted risk of all recurrent stroke ([original cohort: hazard ratio (HR), 1.41; 95% confidence interval [CI], 1.30 to 1.53], [matched cohort: HR, 1.51; 95% CI, 1.37 to 1.68]) and recurrent ischemic stroke ([original cohort: HR, 1.42; 95% CI, 1.30 to 1.55], [matched cohort: HR, 1.56; 95% CI, 1.40 to 1.74]) during the 1-year follow-up period. Conclusions Unrecognized history of AF among patients discharged after an index ischemic stroke hospitalization is associated with higher recurrent stroke risk. Careful history review to uncover a paroxysmal AF history is important for ischemic stroke patients.
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