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Effect of Retinoic Acid on Leptin, Glycerol, and Glucose Levels in Mature Rat Adipocytes In Vitro
Myoung-Sool Do,안인숙,정헌순,D. Vernon Rayner,홍성의 한국식품영양과학회 2004 Journal of medicinal food Vol.7 No.3
To elucidate the effects of retinoic acids (RAs) on adipogenesis and insulin sensitivity, we treated mature adipocytes with two different kinds of RA, 9-cis RA and all-trans RA. Both 9-cis and all-trans RA inhibited the secretion of leptin. However, the inhibition was significantly decreased at a higher dose of each RA. The inhibitory effect of 9-cis RA was synergistically enhanced by the addition of rosiglitazone, a synthetic ligand for PPAR. 9-cis RA also leads to adipogenesis in a dose dependent manner. On the contrary, all-trans RA does not increase adipogenesis in a dose dependent manner. To clarify the anti-diabetic effects of RA, glucose uptake was assessed by estimating glucose concentrations in the medium. 9-cis RA reduced glucose levels in the culture media but all-trans RA did not. In conclusion, all-trans RA does not alter adipogenesis and glucose uptake but does inhibit the leptin secretion. 9-cis RA, however, seems to increase both adipogenesis and glucose uptake through the activation of the RXR/PPAR heterodimer.