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RISS 인기검색어
- 검색키워드
- 저자 : D. Scott McVey (검색결과 2 건)
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Immunogenicity and Efficacy of Schmallenberg Virus Envelope Glycoprotein Subunit Vaccines
Abaineh D. Endalew,Bonto Faburay,Jessie D. Trujillo,Natasha N. Gaudreault,A. Sally Davis,Vinay Shivanna,Sun-Young Sunwoo,Wenjun Ma,Barbara S. Drolet,D. Scott McVey,Igor Morozov,William C. Wilson,Juerg 대한수의학회 2019 Journal of Veterinary Science Vol.20 No.6
The Schmallenberg virus (SBV) is an orthobunyavirus that causes abortions, stillbirths, and congenital defects in pregnant sheep and cattle. Inactivated or live attenuated vaccines have been developed in endemic countries, but there is still interest in the development of SBV vaccines that would allow a differentiationng of infected from vaccinated animals (DIVA). Therefore, an attempt was made to develop novel DIVA-compatible SBV vaccines using SBV glycoproteins expressed in baculovirus. All vaccines and phosphate buffered saline (PBS) controls were prepared with adjuvant and administered subcutaneously to cattle at six6 months (Ed note: Numerals 1 to 9 are written in words.)of age. The first trial included two2 groups of animals vaccinated with either carboxyl-terminus glycoprotein (Gc) or PBS and boosted after two2 weeks. In the second trial, three3 groups of cattle were administered either Gc, Gc and Gnamino-terminus glycoprotein, or PBS with a booster vaccination after three3 weeks. The animals were challenged with the SBV nine9 days after the booster vaccination in the first study, and three3 weeks after the booster vaccination in the second study. Using SBV Gc-specific ELISAenzyme-linked immunosorbent assay, antibodies were first detected in serum samples 14 days after the first vaccination in both trials, and peaked on days seven7 and nine9 after the booster in the first and second trials, respectively. Low titers of neutralizing antibodies were detected in serum from only 3/6 and 2/4 animals in the first and second trial, respectively, at 14 days after the first vaccination. The titers increased 2 to 3-fold after the booster vaccination. On the other hand, SBV-specific RNA was detected in the serum and selective tissues in all animals after the challenge. The SBV candidate vaccines neither prevented viremia nor conferred protection against the SBV infection.
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Dmitriy Smolensky,Davina Rhodes,D. Scott McVey,Zachary Fawver,Ramasamy Perumal,Thomas Herald,Leela Noronha 한국식품영양과학회 2018 Journal of medicinal food Vol.21 No.10
As diet is one of the major controllable factors in cancer development, potentially chemopreventive foods are of significant interest to public health. One such food is sorghum (Sorghum bicolor), a cereal grain that contains varying concentrations of polyphenols. In a panel of 15 sorghum germplasm, we identified strains with higher polyphenol content than previously reported for this grain. Bran extracts from the germplasm with the highest and lowest polyphenol content were then tested against HepG2 and Caco2 cancer cells to assess effects on cancer cell viability, reactive oxygen species, apoptosis, DNA damage, cell cycle arrest, and protein expression patterns. High-polyphenol extracts, but not low-polyphenol extracts, reduced cell viability by inducing apoptosis and cell cycle arrest following production of reactive oxygen species and oxidative DNA damage. The results indicate that high-polyphenol sorghum bran extracts have potential anticancer properties and warrant further research, not only to test against specific cancers but also to elucidate underlying mechanisms of action.
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