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Usability and Evaluation of a Deployed 4G Network Prototype
Cuevas Antonio,Serrano Pablo,Moreno Jose I.,Bernardos Carlos J.,Jahnert Jurgen,Aguiar Rui L.,Marques Victor The Korea Institute of Information and Commucation 2005 Journal of communications and networks Vol.7 No.2
This article presents a field evaluation of an IP-based architecture for heterogeneous environments that has been developed under the aegis of the Moby Dick project, covering UMTS-like (universal mobile telecommunications system) TD-CDMA (time division-code division multiple access) wireless access technology, wireless and wired LANs. The architecture treats all transmission capabilities as basic physical and data-link layers, and replaces all higher-level tasks by IP-based strategies. The Moby Dick architecture incorporates mobile IPv6, fast handovers, AAA-control (authentication, authorisation, accounting), charging and quality of service (QoS) in an integrated framework. The architecture further allows for optimised control on the radio link layer resources. It has been implemented and tested by expert users, and evaluated by real users on field trials with multiple services available.
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Jesus Antonio Pineda-Alegrıa,Jose Ernesto Sa´nchez-Vazquez,Manases Gonzalez-Cortazar,Alejandro Zamilpa,Marıa Eugenia Lopez-Arellano,Edgar Josue Cuevas-Padilla,Pedro Mendoza-de-Gives,Liliana Aguilar-Ma 한국식품영양과학회 2017 Journal of medicinal food Vol.20 No.12
Pleurotus djamor is an edible mushroom that has medicinal properties. This study aimed to assess the in vitro activity of P. djamor extracts and fractions against Haemonchus contortus eggs and exsheathed infective larvae (L3). Crude hydroalcoholic extracts were obtained by maceration and fractions were obtained through chromatography. Metabolite identity was determined using gas chromatography/mass spectrometry (GC-MS) analysis. The results showed that P. djamor extracts had no significant activity against eggs at the concentrations used. However, the extract showed 98.7% and 77% larval mortality 72 h postconfrontation at 320 and at 160 mg/mL, respectively. The chromatography analysis resulted in 23 fractions that were eventually grouped into three fractions (E1, E2, and E3). These fractions showed the following egg hatching inhibition percentages: E1 = 100, E2 = 38.7, and E3 = 5.5 at 10 mg/mL concentration 72 h postexposure. Likewise, larval mortality percentages after this period were 90.6, 100, and 0.44 at 40 mg/mL (P < .05), respectively. The GC-MS showed five major compounds in E1 fraction, including four fatty acids: (i) pentadecanoic, (ii) hexadecanoic, (iii) octadecadienoic, (iv) octadecanoic acid, and one terpene identified as β-sitosterol. We concluded that the edible mushroom P. djamor possesses nematicidal metabolites, which could be used as an alternative anthelmintic treatment.
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Role of Choline in the Modulation of Degenerative Processes: In Vivo and In Vitro Studies
Tania Merinas-Amo,Inmaculada Tasset-Cuevas,Antonio M. Dıaz-Carretero,Angeles Alonso-Moraga,Fernando Calahorro 한국식품영양과학회 2017 Journal of medicinal food Vol.20 No.3
The purpose of the present study was to examine the nutraceutical potential of choline as an added value to its well-known brain nutrient role. Several toxicity, antitoxicity, genotoxicity, antigenotoxicity, and longevity endpoints were checked in the somatic mutation and recombination test in in vivo Drosophila animal model. Cytotoxicity in human leukemia-60 cell line (HL-60) promyelocytic and NIH3T3 mouse fibroblast cells, proapoptotic DNA fragmentation, comet assay, methylation status, and macroautophagy (MA) activity were tested in in vitro assays. Choline is not only safe but it is also able to protect against the DNA damage caused by an oxidative genotoxin. Moreover, it improves the life extension in the animal model. The in vitro results show that it is able to exhibit genetic damage against leukemia HL-60 cells. Single-strand breaks in DNA are observed at the molecular level in treatments with choline, although only a significant hypermethylation on the long interspersed elements-1 and a hypomethylation on the satellite-alpha DNA repetitive DNA sequences of HL-60 cells at the lowest concentration (0.447 mM) were observed. Besides, choline decreased MA at the lower assayed concentration and the MA response to topoisomerase inhibitor (etoposide) is maintained in the presence of treatment with 0.22 mM choline. Taking into account the hopeful results obtained in the in vivo and in vitro assays, choline could be proposed as a substance with an important nutraceutical value for different purposes.
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