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Spatio-Temporal Expression of COK9-Cyclin T1 in Mouse Early Oevelopment
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공압시험용 플러그 노즐의 핀틀 형상 및 작동압력에 따른 유동 특성 분석
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PReAmacy : 소셜 네트워크 서비스에서 사용자의 친밀도를 고려한 개인화 추천 알고리즘
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혼돈신호에 따른 암호화 정도 분석
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Mesenteric cysts^ lymphatic leak^ and cerebral cavernous malformation in a proband with KRIT1‐related disease
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Experimental and Numerical Studies of Delamination in Mode Ⅰ^ Ⅱ of Fiber Metal Laminates
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- 저자 : Chunxiao Wu (검색결과 5 건)
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Chunxiao Wang,Yu-Qiang Wu,Jiang-Bo Yu 제어·로봇·시스템학회 2017 International Journal of Control, Automation, and Vol.15 No.6
This paper studies the problem of controller design for pure-feedback nonlinear systems with asymmetrictime-varying full state constraints. The mean value theorem is employed to transform a pure-feedback system intoa strict-feedback structure with non-affine terms. For the transformed system, a time-varying asymmetric BarrierLyapunov Function (ABLF) with the error variables is employed to ensure the time-varying constraints satisfaction. By allowing the barriers to vary with the desired trajectory in time, the initial condition requirements are relaxedefficiently. The presented control scheme can guarantee that all signals in the closed-loop system are ultimatelybounded. It is also proved that the tracking error converges to an adjustable neighborhood of the origin even in thepresence of disturbance. The performance of the ABLF-based control are illustrated through two examples.
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Preparation and properties of coated silica/aluminum cermet materials via powder metallurgy method
Jieguang Song,Yue Liu,Chunxiao Wu,Xueqing Yang,Huihui Luo,Chunyan He,Chengbin Li,Haizhen Yang 한양대학교 세라믹연구소 2020 Journal of Ceramic Processing Research Vol.21 No.2
Cermet is a combination of metal and ceramic, it exhibits some special properties, so it is one of the most widely usedengineering materials. In this paper, the properties of encapsulated SiO2/Al cermet were prepared by powder metallurgymethod. Results showed that the density of SiO2/Al cermet is increased with an increasing Al content. When the Al contentis high, and the high temperature is sintered, the liquid phase can fully bond the surrounding SiO2 particles to form a relativelycontinuous and dense structure, thereby obtaining a high microstructure density. When the SiO2:Al ratio is increased from 1:1to 1:3, the hardness is gradually increased. The hardness and density of the sample are gradually increased with an increasingmolding pressure. The surface hardness of the cermet is increased first and then decreased with an increasing sinteringtemperature. When the SiO2:Al ratio is 1:3, the holding time is 10 min under molding pressure of 15 MPa, and the sinteringtemperature is 900 °C for 1 h, the surface hardness of the obtained coated SiO2/Al cermet is high, the value is 175.2 HV.
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Jieguang Song,Yue Liu,Chunxiao Wu,Xueqing Yang,Yipeng Gong,Jianzhen Huang,Chunyan He,Huihui Luo,Aixia Chen 한양대학교 세라믹연구소 2020 Journal of Ceramic Processing Research Vol.21 No.1
Cermet application is extensive because it retains the characteristics of ceramic materials and has the advantages of metalmaterials. In this paper, alumina/aluminum cermet materials were prepared through powder metallurgy method. Theinfluence of raw material formula on the properties of alumina/aluminum cermet was investigated on the basis that ceramicmaterials have good wear resistance and high thermal conductivity. Results show that when the mass ratio of alumina toaluminum is 1:3, the prepared cermet samples have excellent properties, highest density, and uniform distribution ofaluminum and alumina. MgO addition exhibits better effect, higher degree of densification, and renders higher hardness andstrength for the sample as compared with SiO2 and Y2O3 addition. The sintered cermet with composite powder prepared viaprecipitation has better properties and higher densities and surface hardness than that prepared via the ball mill method. Therelative density was 97.1%, surface hardness was 875 HV, and electric resistance was 0.0169 Ω·m.
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Zhao Chijun,Jia Xinglin,Pan Yanying,Liao Simeng,Zhang Shuo,Ji Chunxiao,Kuang Guangwei,Wu Xin,Liu Quan,Tang Yulong,Fang Lihua 한국미생물학회 2023 The journal of microbiology Vol.61 No.4
Streptococcus suis serotype 2 (SS2) is an important zoonotic pathogen that can infect humans in contact with infected pigs or their byproducts. It can employ different types of genes to defend against oxidative stress and ensure its survival. The thioredoxin (Trx) system is a key antioxidant system that contributes adversity adaptation and pathogenicity. SS2 has been shown to encode putative thioredoxin genes, but the biological roles, coding sequence, and underlying mechanisms remains uncharacterized. Here, we demonstrated that SSU05_0237-ORF, from a clinical SS2 strain, ZJ081101, encodes a protein of 104 amino acids with a canonical CGPC active motif and an identity 70–85% similar to the thioredoxin A (TrxA) in other microorganisms. Recombinant TrxA efficiently catalyzed the thiol-disulfide oxidoreduction of insulin. The deletion of TrxA led to a significantly slow growth and markedly compromised tolerance of the pathogen to temperature stress, as well as impaired adhesion ability to pig intestinal epithelial cells (IPEC-J2). However, it was not involved in H2O2 and paraquat-induced oxidative stress. Compared with the wild-type strain, the ΔTrxA strain was more susceptible to killing by macrophages through increasing NO production. Treatment with TrxA mutant strain also significantly attenuated cytotoxic effects on RAW 264.7 cells by inhibiting inflammatory response and apoptosis. Knockdown of pentraxin 3 in RAW 264.7 cells was more vulnerable to phagocytic activity, and TrxA promoted SS2 survival in phagocytic cells depending on pentraxin 3 activity compared with the wild-type strain. Moreover, a co-inoculation experiment in mice revealed that TrxA mutant strain is far more easily cleared from the body than the wild type strain in the period from 8–24 h, and exhibits significantly attenuated oxidative stress and liver injury. In summary, we reveal the important role of TrxA in the pathogenesis of SS2.
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Hypoglycemic Effects of Ganoderma lucidum Polysaccharides in Type 2 Diabetic Mice
Chun Xiao,Qingping Wu,Xiao-Bing Yang,Wen Cai,Jian-Bin Tan,Jumei Zhang 대한약학회 2012 Archives of Pharmacal Research Vol.35 No.10
Our aims were to investigate the hypoglycemic effects and mechanisms of action of Ganoderma lucidum polysaccharides (GLPs) administered for 7 days in type 2 diabetic mice. The mice were randomly divided into four groups (8 mice/group): normal control group, diabetic control group, low-dose GLP-treated diabetic group (50 mg/kg/d), and high-dose GLP-treated diabetic group (100 mg/kg/d). Diabetes was induced by streptozotocin injection and high-fat dietary feeding. At the end of the study, fasting serum glucose, insulin, body weight (BW) and epididymal white adipose tissue weight were measured. The hepatic mRNA levels of glycogen phosphorylase (GP), fructose-1,6-bisphosphatase (FBPase), phosphoenolpyruvate carboxykinase (PEPCK) and glucose-6-phosphatase (G6Pase) genes were determined by real-time polymerase chain reaction. Both doses of GLPs significantly decreased fasting serum glucose, insulin and epididymal fat/BW ratio compared with the diabetic control group (p < 0.05). The hepatic mRNA levels of GP, FBPase, PEPCK and G6Pase were significantly lower in both GLP-treated groups compared with the diabetic control group. Taken together, GLPs significantly decrease fasting serum glucose levels in type 2 diabetic mice in a dose-dependent manner. The decreases in fasting serum glucose levels may be associated with decreased mRNA expression levels of several key enzymes involved in gluconeogenesis and/or glycogenolysis.
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