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A full-quantum three-dimensional analysis on the dynamics of a single atom in an all-optical trap
Young-Tak Chough,Young-Tak Chough 한국물리학회 2004 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.44 No.2
We analyze two recent \state-of-the-art" experiments on the dynamics of a single atom in an all-optical trap by using computer simulations based on the theory of quantum trajectories. We compare the so-called \quasi-classical" simulations of the experiments with our full-quantum calculations and discuss how far the two models agree. We point out that the atomic wave packet spreading in quantum calculations is mimicked by an interesting behavior of atom skipping around from a potential minimum to another in the quasi-classical model.
Chough, Chieyeon,Joung, Misuk,Lee, Sunmin,Lee, Jaemin,Kim, Jong Hoon,Kim, B. Moon Elsevier 2018 Bioorganic & medicinal chemistry Vol.26 No.8
<P><B>Abstract</B></P> <P>A series of 3(<I>R</I>)-aminopyrrolidine derivatives were designed and synthesized for JAK1-selective inhibitors through the modification of tofacitinib’s core structure, (3<I>R</I>,4<I>R</I>)-3-amino-4-methylpiperidine. From the new core structures, we selected (<I>R</I>)-<I>N</I>-methyl-<I>N</I>-(pyrrolidin-3-yl)-7<I>H</I>-pyrrolo[2,3-<I>d</I>]pyrimidin-4-amine as a scaffold for further SAR studies. From biochemical enzyme assays and liver microsomal stability tests, (<I>R</I>)-3-(3-(methyl(7<I>H</I>-pyrrolo[2,3-<I>d</I>]pyrimidin-4-yl)amino)pyrrolidin-1-yl)-3-oxopropanenitrile (<B>6</B>) was chosen for further <I>in vivo</I> test through oral administration. Compound <B>6</B> showed improved selectivity for JAK1 compared to that of tofacitinib (IC<SUB>50</SUB> 11, 2.4 × 10<SUP>2</SUP>, 2.8 × 10<SUP>3</SUP>, and 1.1 × 10<SUP>2</SUP> nM for JAK1, JAK2, JAK3, and TYK2, respectively). In CIA and AIA model tests, compound <B>6</B> exhibited similar efficacy to tofacitinib citrate.</P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>
Chough, Yun-Sung,Kim, Mie-Young The Pharmaceutical Society of Korea 1973 약학회지 Vol.17 No.3
Fifteen thiosemicarbazone derivatives were synthesized and evaluated for their antimicrobial activity against Staphylococus aureus, Escherchia coli and Pichia sp. Anticancer activity in vitro was also tested against human carcinoma HeLa cells.
Chough, Chieyeon,Lee, Sunmin,Joung, Misuk,Lee, Jaemin,Kim, Jong Hoon,Kim, B. Moon The Royal Society of Chemistry 2018 MedChemComm Vol.9 No.3
<P>Based on (<I>R</I>)-<I>N</I>-methyl-<I>N</I>-(5-azaspiro[2.4]heptan-7-yl)-7<I>H</I>-pyrrolo[2,3-<I>d</I>]pyrimidin-4-amine as a core scaffold, we identified (<I>R</I>)-3-(7-(methyl(7<I>H</I>-pyrrolo[2,3-<I>d</I>]pyrimidin-4-yl)amino)-5-azaspiro[2.4]heptan-5-yl)-3-oxopropanenitrile [(R)-6c] as a JAK1 selective inhibitor. The structural design was based on the combination of tofacitinib's 7-deazapurine and 5-azaspiro[2.4]heptan-7-amine. Compound (R)-6c exhibited an IC50 value of 8.5 nM against JAK1 with a selectivity index of 48 over JAK2. To optimize (R)-6c as a lead compound, we performed <I>in vitro</I> ADME, hERG, kinase profiling, and pharmacokinetic tests. Mouse and rat <I>in vivo</I> studies verified that (R)-6c exhibited desired efficacies in CIA and AIA models.</P>
Chough Chan Suk(趙燦錫) 경인교육대학교 기전문화연구소 1992 기전문화연구 Vol.21 No.-
According to the Boopyung town publication, such various names have been handed down as Jubuto, Jangje, Suju, Annam, Gyeyang, Gilju, Boopyung, etc.. Since the 2nd year of King Chungsun(A. D. 1310) in Koryo Dynasty, it s been called Boopyung-bu, and since the 13th year of Taejong(A. D. 1413) of Chosun Dynasty, it s been called Boopyung-dohobu. The purpose of this paper is to investigate the changes of administrative district and the origin of each dong in Boopyung, focused on mainly Inchon City, The administractive districts are considered for periodical differences : (1) The Age of Boopyung-dohobu, (2) The Age of Boopyung-gun, (3) The Age of Boochun-gun, (4) The Age of Inchon-bu, (5) The Age of Inchon City and Inchon City of Government s direct control. The origin of each dong are examined In view of administrative division as well as legally fixed dong. The Boopyung area during the period of Boopyung-dohobu covered all 15 Myun and 84 Ri : Boonae-myun, Sangojung-myun, Haojung-myun, Oksan-myun, Dongsojung-myun, Su-myun, Majang-myun, Sukchun-myun, Mowolgot-myun, Hwango-myun, etc.. The administrative building of Boopyung-dohobu was situated in Kyesan-dong, Buk-gu(the present site of Boopyung Primary School). The present area of Buk-gu in Inchon City, however, is limited to the land of old Boonae-myun, Dong-myun, Su-myun, Donsojung-myun, Majang- myun, Hwango-myun, etc.. The present address of Buk-gu administrative building is 442-1, Boopyung-dong, Inchon City; covering 29 administrative dongs (32 legally fixed dongs) as of September, 1992. A characteristic is discovered from the transitional process of Boopyung area. The name of Boopyung as the administrative unit gun disappeared completely when the new Boochun-gun appeared by the integration of most Inchon-bu area 1914. Boopyung-dong, instead, as the unit name of dong remains at the present position. This dates back to the time of opening Gyungin Railway in 1899, when Boopyung station was situated in the present place (once Dongsojung-myun Daejung-ri). The old central district of Boopyung town where Boopyung-dohobu administrative building stood is displaced with the present Boopyung Primary School, but the name of the district is chnged to Kyesan-dong. What it means is that Boopyung met with the transition from farming area to commerce and industry area.
Flow cytometric DNA content study on Uterine Leiomyomatous tumors
Chough, Soo Yong,Lee, Kap N. 고려대학교 의과대학 1993 고려대 의대 잡지 Vol.30 No.2
종양에서 세포의 비정상적인 분열산은 종양의 한 특징으로 생각되어 왔다. 이러한 종양의 한 특징인 세포의 분열상을 연구하는 여러 방법중 최근에 소개된 유세포측정법을 이용한 세포의 분열상에 대한 연구가 활발하다. 그러나 대부분 epithelial세포에 관한 연구 논문들이고 sarcomatoid세포에 관한 연구는 드물다. 이에 본 연구자들은 고려대학교 부속병원들에서 자궁 절제술로 제거된 평활근 종양 중 양성 자궁 평활근종 21예, 심프라스틱(symplastic) 자궁 평활근종 2예, 이형성(atypical) 자궁평활근종 1예, 경계형(borderline) 자궁 평활근종 1예와 악성 평활근종 3예를 대상으로 이들의 파라핀 포매된 조직중 대표적인 것을 선정하여 유세포 측정을 시행하고 그 분열상에 있어서 어떠한 특징이 있는지 비교 검토한 결과, 21예의 양성 자궁 평활근종중 단지 2예와 3예의 악성 자궁 평활근종중 1예에서만 이수배수체(aneuploidy) 양상을 보였고, 다른 모든 예에서는 이배체(diploidy)를 보였다. 히스토그램 분석상, 양성 자궁 평활근종과 심프라스틱, 이형성, 경계형 자궁 평활근종과 악성 평활근종의 G_(2)+M/G_(1)비에서 유의한 차이를 보여 주었으며(P<0.05), G_(2)+M/G_(1)비에서는 양성과 양성이 아닌 군사이에서 아주 유의한 차이를 보여 주었다(P<0.001). 그러나 배수성 양상, G_(0)/G_(1), S, G_(2)/M, 증식지수(proliferation index)와 DNA지수는 어느 군사이에서도 차이를 보여주지 않았다. 양성종양(leiomyoma) 및 악성종양(leiomyosarcoma)의 이배체군과 이수배수체군들 사이의 각각의 비교에서 이배체군의 G_(2)+M/G_(1)비에서 유의한 차이를 보여주었고, 이수배수체군에서 G_(0)/G_(1)비에서 다소의 차이를 보여 주었으나 통계학적으로 유의하지는 않았다. Flow cytometric DNA content analysis of 21 cases of benign leiomyomas, 2 cases of symplastic leiomyomas, 1 case of atypical leiomyoma, 1 case of borderline malignancy of leiomyoma and 3 cases of leiomyosarcomas with paraffin blocks from uterine hysterectomy specimen were performed. Only two cases out of 21 cases of benign leiomyomas (9%) showed aneuploid patterns, one out of three leiomyosarcomas was aneuploidy and all others were diploidy. In histograms, the only G_(2)+M/G_(1) ratio fraction showed significant differences between benign leiomyomas and other symplastic, atypical leiomyomas, borderline malignancy of leiomyoma and leiomyosarcomas(P<0.05). In histogramic fractions between benign and non-benign tumors, there were very significants differences in G_(0)+M/G_(1) ratio(P<0.001). There were no differences in ploidy pattern, G_(0)/G_(1) fraction, S phase fraction, G_(2)+M fraction, proliferation index and DNA index. Between benign leiomyomas and leiomyosarcomas, in cases of diploid tumors, only G_(2)+M/G_(1) ratio showed significant difference (P<0.05) and in cases of aneuploid tumors, there was only suggestion of difference in only G_(0)/G_(1) fraction.
Syntheses and antimicrobial and antitumor activities of isatin derivatives
Chough, Yun-Sung,Kang, Kun-Il The Pharmaceutical Society of Korea 1973 약학회지 Vol.17 No.3
Eight isatin N-Mannich bases were synthesized and tested their antimicrobial and antitumor activities. N-Piperidinomethylisatin-(N-cyclohexyl)-thiosemicarbazone is active against St. aureus at 10${\mu}$g/disk and isatin thiosemicarbazone against P. chrysogenum at 10${\mu}$g disk.