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Choudhury, Aaheli Roy,Ju, Zhenyu,Djojosubroto, Meta W,Schienke, Andrea,Lechel, Andre,Schaetzlein, Sonja,Jiang, Hong,Stepczynska, Anna,Wang, Chunfang,Buer, Jan,Lee, Han-Woong,von Zglinicki, Thomas,Gans Nature Pub. Co 2007 Nature genetics Vol.39 No.1
Telomere shortening limits the proliferative lifespan of human cells by activation of DNA damage pathways, including upregulation of the cell cycle inhibitor p21 (encoded by Cdkn1a, also known as Cip1 and Waf1)) (refs. 1–5). Telomere shortening in response to mutation of the gene encoding telomerase is associated with impaired organ maintenance and shortened lifespan in humans and in mice. The in vivo function of p21 in the context of telomere dysfunction is unknown. Here we show that deletion of p21 prolongs the lifespan of telomerase-deficient mice with dysfunctional telomeres. p21 deletion improved hematolymphopoiesis and the maintenance of intestinal epithelia without rescuing telomere function. Moreover, deletion of p21 rescued proliferation of intestinal progenitor cells and improved the repopulation capacity and self-renewal of hematopoietic stem cells from mice with dysfunctional telomeres. In these mice, apoptotic responses remained intact, and p21 deletion did not accelerate chromosomal instability or cancer formation. This study provides experimental evidence that telomere dysfunction induces p21-dependent checkpoints in vivo that can limit longevity at the organismal level.
FIXED POINTS OF GENERALIZED KANNAN TYPE MAPPINGS IN GENERALIZED MENGER SPACES
Choudhury, Binayak S.,Das, Krishnapada Korean Mathematical Society 2009 대한수학회논문집 Vol.24 No.4
Generalized Menger space introduced by the present authors is a generalization of Menger space as well as a probabilistic generalization of generalized metric space introduced by Branciari [Publ. Math. Debrecen 57 (2000), no. 1-2, 31-37]. In this paper we prove a Kannan type fixed point theorem in generalized Menger spaces. We also support our result by an example.
WEAK INEQUALITIES WITH CONTROL FUNCTIONS AND FIXED POINT RESULTS
Choudhury, Binayak S. The Korean Society for Computational and Applied M 2010 Journal of applied mathematics & informatics Vol.28 No.3
In recent times control functions have been used in several problems of metric fixed point theory. Also weak inequalities have been considered in a number of works on fixed points in metric spaces. Here we have incorporated a control function in certain weak inequalities. We have established two fixed point theorems for mapping satisfying such inequalities. Our results are supported by examples.
Short and long distance contributions to B→K<sup>∗</sup>γγ
Choudhury, S.R.,Cornell, A.S.,Mahajan, Namit Elsevier 2004 Physics letters: B Vol.580 No.3
<P><B>Abstract</B></P><P>We study the decay of the neutral <I>B</I> meson to K<sup>∗</sup>γγ within the framework of the Standard Model, including long distance contributions.</P>
Choudhury, Payel,Bhunia, Biswanath,Bandyopadhyay, Tarun Kanti,Ray, Rup Narayan The Korean Electrochemical Society 2021 Journal of electrochemical science and technology Vol.12 No.1
To improve the potential of single chamber microbial fuel cells (SCMFCs) as an applicable technology, the main challenge is a practical application for larger scales bioenergy production from potent exoelectrogenic microorganism with real dairy wastewater. To increase power generation, three individual MFCs were together operated in series best under the fed batch condition for 15 days. The volume of MFC 1 and MFC 2 is "300 mL" and MFC 3 is "500 mL" respectively. The individual MFCs 1, MFC 2 and MFC 3 gives an open circuit voltage of 0.60 V, 0.66 V and 0.55 V and result in total working voltage when connected in series of 1.745V, which lead an LED to glow. The maximum power densities obtained from MFC 1, MFC 2 and MFC 3 are 62 mW/㎡, 50 mW/㎡ and 45 mW/㎡ (normalized to the surface area of the anodic electrode, which was 50 ㎠ for all three MFCs), and corresponding to current densities of 141 mA/㎡, 155 mA/㎡ and 123 mA/㎡, respectively. Therefore this work suggests the cheapest way to connect microbial fuel cells in series to gain power with the lowest operating cost and chemical oxygen demand (COD) removal.