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A novel practical cleavage of tert-butyl esters and carbonates using fluorinated alcohols
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Influence of Method of Asymmetric Trunk Mobilization on Shaping of a Physiological Thoracic Kyphosis in Children and Youth Suffering from Progressive Idiopathic Scoliosis
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Notch signals contribute to preserve the multipotentiality of human CD34^+CD38^-CD45RA^-CD90^+ hematopoietic progenitors by maintaining T cell lineage differentiation potential
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The effect of spatial resolution on the accuracy of landslide susceptibility mapping: a case study in Boun^ Korea
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산지 소유역에서 분포형 모형의 적용성에 대한 연구
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ON LEBESGUE NONLINEAR TRANSFORMATIONS
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- 저자 : Chisei Ra (검색결과 1 건)
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Most Highly Cytokinergic IgEs Have Polyreactivity to Autoantigens
Jun-ichi Kashiwakura,Yoshimichi Okayama,Masutaka Furue,Kenji Kabashima,Shinji Shimada,Chisei Ra,Reuben P. Siraganian,Yuko Kawakami,Toshiaki Kawakami 대한천식알레르기학회 2012 Allergy, Asthma & Immunology Research Vol.4 No.6
Purpose Monomeric IgE molecules, when bound to the high-affinity receptor, exhibit a vast heterogeneity in their ability to induce survival promotion and cytokine production in mast cells. At one end of this spectrum, highly cytokinergic (HC) IgEs can induce potent survival promotion, degranulation, cytokine production, migration, etc., whereas at the other end, poorly cytokinergic (PC) IgEs can do so inefficiently. In this study, we investigated whether IgEs recognize autoantigens and whether IgEs' binding of autoantigens correlates with difference s in HC versus PC properties. Methods Enzyme-linked immunosorbent assays were performed to test whether IgEs bind antigens. Histamine-releasing factor in human sera was quantified by western blotting. Cultured mast cells derived from human cord blood were used to test the effects of human sera on cytokine production. Results Most (7/8) of mouse monoclonal HC IgEs exhibited polyreactivity to double-stranded DNA (dsDNA), single-stranded DNA (ssDNA), β-galactosidase, thyroglobulin and/or histamine-releasing factor. By contrast, mouse PC IgEs failed to react with these antigens. A human monoclonal HC IgE also showed polyreactivity to histamine-releasing factor, dsDNA and ssDNA. Interestingly, sera from atopic dermatitis patients showed increased reactivity to ssDNA and β-galactosidase and increased levels of histamine-releasing factor. Some atopic dermatitis patients, but not healthy individuals, had substantial serum levels of HRF-reactive IgE. Sera from atopic dermatitis patients with high titers of DNA-reactive IgE could induce several fold more IL-8 secretion in human mast cells than sera from healthy individuals. Conclusions The results show that most HC, but not PC, IgEs exhibit polyreactivity to autoantigens, supporting the autoimmune mechanism in the pathogenesis of atopic dermatitis.
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