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ER membrane protein complex subunit 6 (EMC6) is a novel tumor suppressor in gastric cancer
( Xiaokun Wang ),( Yan Xia ),( Chentong Xu ),( Xin Lin ),( Peng Xue ),( Shijie Zhu ),( Yun Bai ),( Yingyu Chen ) 생화학분자생물학회(구 한국생화학분자생물학회) 2017 BMB Reports Vol.50 No.8
The endoplasmic reticulum (ER) membrane protein complex subunit 6 (EMC6) is a novel human autophagy-related molecule. Here, using tissue microarray and immunohistochemistry, we report that EMC6 protein is lost or reduced in glandular cells of patients with gastric adenocarcinoma, compared to normal stomach mucosa. Overexpression of EMC6 in gastric cancer cells inhibited cell growth, migration, invasion, and induced apoptosis and cell cycle arrest at S-phase. Further investigation suggested that EMC6 overexpression in BGC823 human adenocarcinoma gastric cancer cells reduced tumorigenicity in a xenograft model, demonstrating that EMC6 has the characteristics of a tumor suppressor. This is the first study to show that EMC6 induces cell death in gastric cancer cells. The molecular mechanism of how EMC6 functions as a tumor suppressor needs to be further explored. [BMB Reports 2017; 50(8): 411-416]
DISTRIBUTED FORMATION CONTROL OF HOMOGENEOUS VEHICLE PLATOON CONSIDERING VEHICLE DYNAMICS
Liwei Xu,Weichao Zhuang,Guodong Yin,Chentong Bian 한국자동차공학회 2019 International journal of automotive technology Vol.20 No.6
Vehicle dynamics plays a significant role on the formation of a vehicle platoon, especially at high speed condition. This paper proposes a distributed platoon formation framework for homogeneous autonomous vehicles which takes the vehicle dynamics into consideration. The boundaries of vehicle stability are firstly calculated by considering both lateral dynamics and actuator saturation. By combining the stability boundaries with multi-objective flocking (MOF) algorithm, a distributed formation controller is designed, which can form the vehicle platoon with high cruising speed steadily and rapidly. In addition, a low-level tracking controller is proposed to constitute a hierarchical control architecture which can achieve stable and accurate formation of platoon. Simulation results show the proposed platoon formation controller achieves safe, stable and rapid platoon formation than the traditional MOF-based formation controller which does not consider the vehicle dynamics.