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MiR-601 inhibited small cell lung cancer progression by modulating SIRT1
Ding Hao,Gong Chenhu,Zhang Zhihong,Xu Hui,Ma Chunping 대한독성 유전단백체 학회 2023 Molecular & cellular toxicology Vol.19 No.3
Background Dysfunction of microRNAs (miRNAs) contribute to small cell lung cancer (SCLC) progression. Accumulating evidence indicated miR-601, acted as a tumor suppressor gene, has shown an altered expression pattern in multiple cancers. However, little was known about in terms of the function of miR-601 during SCLC progression. Objective Our project intended to illustrate the functions of miR-601 during the development and metastasis of SCLC. Results We found a decreased expression of miR-601 in SCLC tumor tissues and cell lines. Moreover, functional studies suggested that miR-601 overexpression resulted in a reduced cell growth and induced apoptosis of SCLC cells. Notably, sirtuin 1 (SIRT1) was identifi ed as a putative target of miR-601. MiR-601 suppressed SIRT1 expression via interacting with the 3′-untranslated region (UTR) of SIRT1 in SCLC cells. Also, SIRT1 expression was negatively associated with that of miR-601 in SCLC tissues. The restoration of SIRT1 alleviated the inhibitory eff ect of miR-601 on SCLC progression. Conclusion Our data documented the tumor-suppressive function of miR-601 in SCLC via targeting SIRT1, suggesting miR-601 as a new potential therapeutic approach for SCLC treatment.
Zhigang Yin,Wei Sun,Yuehua Hu,Runqing Liu,Wei Jiang,Chenhu Zhang,Qingjun Guan,Chenyang Zhang 한국공업화학회 2017 Journal of Industrial and Engineering Chemistry Vol.52 No.-
A novel organic compound acetic acid-[(hydrazinylthioxomethyl)thio]-sodium was synthesized andcharacterized. Theflotation performance and adsorption mechanism of AHS to galena were investigatedby micro, benchflotation tests, UV spectra, zeta potential, FTIR and XPS measurements. The resultsdemonstrated that AHS exhibited superior depressing power to galena and could be used as selectivedepressant forflotation separation of molybdenite from galena. The results of UV spectra, FTIR, zetapotential and XPS measurements demonstrated that AHS chemisorb on galena surface by formingfivememberedcheat ring with releasing of H ions. Therefore, the possible adsorption mode of AHS on galenasurface was recommended.