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- 저자 : Chen Jinghong (검색결과 5 건)
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Chen Qun,Kao Xibin,Gao Yan,Chen Jinghong,Dong Zhaoheng,Chen Chen 대한독성 유전단백체 학회 2023 Molecular & cellular toxicology Vol.19 No.1
Backgrounds Nitric oxide (NO) plays a key role in the pathological chondrocyte apoptosis of osteoarthritis (OA). Cytoskeletal proteins form cytoskeleton network to maintain normal chondrocyte structure and function. JNK and ERK pathways are the signal pathways involved in the cell apoptosis. The role of cytoskeletal proteins in cytoskeleton perturbation and cell apoptosis was investigated in this study. Objectives In vitro cell apoptosis was induced in rabbit articular chondrocytes by NO donor Sodium Nitroprusside (SNP). The JNK-specific inhibitor SP600125 and ERK-specific inhibitor PD98059 were employed to clarify the mechanism. The level of apoptosis was evaluated by TUNEL assay and Annexin V flow cytometry. Results SNP induced concentration-dependent apoptosis, which was further enhanced by PD98059 but reduced by SP600125. Furthermore, PD98059 significantly increased caspase-3 expression and activity respectively, whereas SP600125 reduced caspase- 3 expression and activity. SP600125 increased the cytoskeletal protein mRNA and protein expression, while PD98059 decreased them. Conclusion Intracellular JNK/ERK pathways were involved in chondrocyte apoptosis induced by SNP through oppositely regulated effects on cytoskeletal proteins; ERK pathway protected cytoskeletal protein from dissolution via inhibition of caspase-3 activation, while JNK pathway promoted the dissolution via activation of caspase-3 activity.
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Jinghong Wang,Manman Chen,Wenyu Yan,Youran Zhi,Zhirong Wang 대한토목학회 2019 KSCE JOURNAL OF CIVIL ENGINEERING Vol.23 No.1
In public gathering places, pedestrian flow congestion may happen in transportation bottlenecks. Limitations exist in the conventional judgment of congestion by considering the crowd density or the walking speed merely. In this paper, a data-driven mathematical approach based on Kernel Density Estimation (KDE) to analyze the probability of pedestrian flow congestion is proposed, which comprehensively considers the walking speed, the crowd density and the flow rate when pedestrians walk towards possible bottlenecks. With the case study of Nanjing metro station during rush hours, the advantages of non-parametric KDE compared with traditional parametric normal distribution estimation are analyzed and the optimal bandwidth for KDE is also discussed. The case study shows that the proposed method can obtain a more reliable quantitative assessment of congestion risk, as it overcomes the limitation of parametric estimation that relies on experience, and also avoids biased assessment of congestion that merely concerns single parameter of pedestrian flow. Finally, an assessment framework for dynamic congestion risk at bottlenecks is suggested. With this framework, the change of congestion situations of a monitored region can be mastered through data-driven approach, and thus the transformation of normal flowing to congestion of the crowd can be quantified through probabilistic analysis.
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Jinghong Zhou,Long Zhao,Hong Chen,Mingguang Zhang,Zhijun Sui,Xinggui Zhou 한국화학공학회 2010 Korean Journal of Chemical Engineering Vol.27 No.5
Carbon nanofiber (CNFs) supported Ru catalysts for sorbitol hydrogenolysis to ethylene glycol and propylene glycol were prepared by incipient wetness impregnation, calcination and reduction. The effect of calcination on catalyst properties was investigated using thermal gravimetry analysis, temperature-programmed reduction, X-ray diffraction,X-ray photoelectron spectroscopy, transmission electron microscopy and N2 physisorption. The results indicated that calcination introduced a great amount of surface oxygen-containing groups (SOCGs) onto CNF surface and induced the phase transformation of Ru species, but slightly changed the texture of Ru/CNFs. The catalytic performance in sorbitol hydrogenolysis showed that Ru/CNFs catalyst calcined at 240 oC presented the highest glycol selectivities and reasonable glycol yields. It was believed that the inhibition and confinement effect of SOCGs around Ru particles as well as the high dispersion of Ru particles was the key factor for the catalytic activity.
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Manman Chen,Jinghong Wang,Youran Zhi,Jinhua Sun 대한토목학회 2019 KSCE JOURNAL OF CIVIL ENGINEERING Vol.23 No.5
The intersection of pedestrian flows is a general phenomenon in daily pedestrian traffic and emergency evacuation. However, lacking of effective controls in crowed areas will result in pedestrian deceleration, stopping, and even threats to safety in evacuation. This paper focused on exploring the influence of different intersecting angles on evacuation efficiency of pedestrian flows in high volume. Through establishing a bidirectional pedestrian flow model with different intersecting angles for a busy metro station in China based on the social force model, two factors, namely the impact between pedestrians and the conflict frequency, were firstly proposed and validated as that playing major roles in influencing the evacuation efficiency during the pedestrian intersection. With the case study, it is found that the best intersecting angle is 120 degree and angles between 40 and 80 degree are unfavorable in optimizing the average crowd speed and the crowd density. The results are verified based on the comparative analysis with some existing experimental results. The outcomes of this work can offer some guidelines to control the intersection of pedestrian flows during evacuation and can make contributions to a proposal for the related, optimized design of a structure to increasing the evacuation efficiency of a dense crowd.
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Wang Hanming,Zhao Jinghong,Guo Guoqiang,Chen Hansi,Xiong Yiyong,Yan Sinian 대한전기학회 2023 Journal of Electrical Engineering & Technology Vol.18 No.2
Due to its simple structure, the linear induction motor provides a linear driving force without any intermediate conversion devices. Linear induction motors are gradually used in various applications, including rail transit and the national defense industry. However, linear induction motors are affected by the end-effect phenomenon and suffer from problems such as low efficiencies and low power factors. In this paper, to optimize the performance of short primary double-sided linear induction motors (SP-DLIMs), first, a new analytical model is established based on an equivalent circuit considering both transverse and longitudinal end effects. Second, to analyze the impact of main parameters on the output characteristics of SP-DLIMs, a simple iterative design method (IDM) is presented. Third, a multi-objective optimal design method is proposed to optimize the efficiency, power factor and tooth weight of SP-DLIMs, with proposed design constraints and four different optimization problems. Moreover, an improved differential evolutionary (IDE) algorithm is proposed to optimize the design. A comparison of the results proved that the IDE yielded a competitive performance to those of other advanced heuristic algorithms. Finally, a three-dimensional time-stepping finite-element method was utilized to verify the validity of the optimization results.
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