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Wang Hui-Ching,Moi Sin-Hua,Chan Leong-Perng,Wu Chun-Chieh,Du Jeng-Shiun,Liu Pei-Lin,Chou Meng-Chun,Wu Che-Wei,Huang Chih-Jen,Hsiao Hui-Hua,Pan Mei-Ren,Chen Li-Tzong 생화학분자생물학회 2023 Experimental and molecular medicine Vol.55 No.-
Personalized genetic profiling has focused on improving treatment efficacy and predicting risk stratification by identifying mutated genes and selecting targeted agents according to genetic testing. Therefore, we evaluated the role of genetic profiling and tumor mutation burden (TMB) using next-generation sequencing in patients with head and neck squamous cell carcinoma (HNSC). The relapse mutation signature (RMS) and chromatin remodeling mutation signature (CRMS) were explored to predict the risk of relapse in patients with HNSC treated with concurrent chemoradiotherapy (CCRT) with platinum-based chemotherapy. Patients in the high RMS and CRMS groups showed significantly shorter relapse-free survival than those in the low RMS and CRMS groups, respectively (p < 0.001 and p = 0.006). Multivariate Cox regression analysis showed that extranodal extension, CCRT response, and three somatic mutation profiles (TMB, RMS, and CRMS) were independent risk predictors for HNSC relapse. The predictive nomogram showed satisfactory performance in predicting relapse-free survival in patients with HNSC treated with CCRT.
A BINARY OBSERVING PROJECT ON THE NCUO SPECKLE INTERFEROMETER
TSAY WEAN-SHUN,KUO HUI-JEAN,CHAN PEI-CHING The Korean Astronomical Society 1996 Journal of The Korean Astronomical Society Vol.29 No.suppl1
Speckle Interferometer equipped with an ITT intensified CCD have been used on the NCUO ( National Central University Observatory, Taiwan) 24-inch telescope for studying the orbits of bright binary systems selected from the Yale's Bright Star Catalogue. The high resolution and high sensitivity ITT intensified solid state video camera ( F4577 ) has external gain and gate control functions which will simplify the design of the speckle camera and allow us to do precise speckle photometry. The goal of this project is trying to study the bright binary systems with separations between the average size of seeing disk and the diffraction limit of the 24-inch telescope. Recently some observing data have been reduced and compared with the other teams' results. We are now improving the data reduction technology and trying to use real time observing mode on the monthly routine observation.