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Common interleukin 10 polymorphism associated with decreased risk of tuberculosis
신형두,Lyoung Hyo Kim,정현섭,In Hee Lee,Seung Kyu Park,Byung Lae Park1, 생화학분자생물학회 2005 Experimental and molecular medicine Vol.37 No.2
Interleukin 10 (IL10) is a powerful TH2-cel cyto-kine that inhibits lymphocyte replication and secretion of inflammatory cytokines. The genetic associations of polymorphisms in IL10 with clini-cal manifestations of tuberculosis (TB) were exa-mined in a large number of patients with clinical TB infection (n = 459) and normal controls (n = 871). One comon promoter SNP (IL10 -592 A>C) was found to be significantly asociated with decreased risk of TB manifestation. The fre-quency of the "C"-bearing genotype was higher in normal controls than in patients with clinical TB infection (P = 0.005, OR = 0.69). A sumary of the genetic effect of IL10 -1082 A>G, the other nearby promoter SNP, in other ethnic groups is also presented.