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        S1000A12, Chitotriosidase, and Resolvin D1 as Potential Biomarkers of Familial Mediterranean Fever

        Ali Taylan,Oguz Gurler,Burak Toprak,Ali Riza Sisman,Hulya Yalcin,Ayfer Colak,Ismail Sari 대한의학회 2015 Journal of Korean medical science Vol.30 No.9

        Familial Mediterranean fever (FMF) is an auto-inflammatory disease characterised by periodic inflammatory attacks. We investigated changes in monocyte-granulocyte derived S10012A and chitotriosidase in both the attack and silent period of FMF for better estimation of inflammation. Endogenous resolvin was determined for utility to restrict inflammation. This study included 29 FMF patients (15 M/14 F) and 30 healthy controls (15 M/15 F). Serum levels of highly sensitive C-reactive protein, serum amiloid A (SAA), S100A12, chitotriosidase, and resolvin D1 were measured. Age, sex, body mass indexes, and lipids were similar between patients and controls. Biomarkers including hs-CRP, SAA, S100A12, chitotriosidase, and resolvin D1 were higher in the attack period of FMF patients compared to controls (P < 0.001). When FMF patients in the silent period were compared with their attack period, hs-CRP, SAA, and chitotriosidase were found elevated in the attack period (P < 0.001, P < 0.001, and P = 0.02 respectively). Serum levels of SAA, S100A12, chitotriosidase, and resolvin D1 in the silent period of FMF patients were still found elevated compared to healthy controls, indicating subclinical inflammation (P < 0.001, P < 0.001, P = 0.009, and P < 0.001 respectively ). In subgroup analysis, patients with M694V homozygote and heterozygote mutations had higher S10012A and hs-CRP compared to other mutation carriers. Our findings indicate that chitotriosidase and S10012A are useful in diagnosis and detection of subclinical inflammation and/or assessment of disease activity in FMF patients. They could be more informative for inflammation in various disease states compared to hsCRP and SAA. Resolvin D1 is elevated in both the attack and silent periods of FMF. It may be helpful to restrict inflammation.

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        An Investigation on Comfort Properties of Dyed Mulberry Silk/Cotton Blended Fabrics

        Memik Bunyamin Uzumcu,Burak Sari,Nida Oglakcioglu,Huseyin Kadoglu 한국섬유공학회 2019 Fibers and polymers Vol.20 No.11

        Mulberry silk is one of the well known silk types. Especially, its lustrous appearance and handle properties makethis fiber type an important natural source for textiles. Even if its properties let the fiber to be produced by itself, blendingwith other fiber types can be preferred in order to reduce raw material costs and make it more affordable. Cotton can be agood companion to this fiber type because of its tendency to be textile material. In this study, mulberry silk/combed cottonblended yarns were produced by using siro and ring spinning systems, in three different yarn counts. These yarns were dyedand then knitted in a laboratory type circular knitting machine. The comfort properties of these fabrics were investigated. According to test results, increasing silk content in the blend and using the siro spinning system positively affected thecomfort properties of fabrics, in general.

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