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        Increased Low-Density Lipoprotein Cholesterol Levels after 6 Months of Citalopram Treatment in Patients with Panic Disorder

        HyunWook Cho,BumHee Yu 대한신경정신의학회 2007 PSYCHIATRY INVESTIGATION Vol.4 No.1

        Objective-Panic disorder is associated with an increased cardiovascular risk. Furthermore, several studies reported increased cholesterol levels after treatment with selective serotonin reuptake inhibitors (SSRIs). Methods-We examined the serum cholesterol levels in 21 panic disorder patients before and after 24 weeks of treatment with citalopram. Results-The levels of serum low-density lipoprotein cholesterol (LDL-C) were significantly increased after the treatment, whereas there were no significant changes in the levels of serum total cholesterol, triglyceride and high-density lipoprotein cholesterol (HDL-C). Significant weight changes were observed as well. Conclusions-Citalopram should be used with caution when panic patients have high risk of cardiovascular disorders.

      • SCIESSCISCOPUSKCI등재

        The Positive and Negative Affect Schedule: Psychometric Properties of the Korean Version

        YoungJin Lim,BumHee Yu,DohKwan Kim,JiHae Kim 대한신경정신의학회 2010 PSYCHIATRY INVESTIGATION Vol.7 No.3

        Objective-The Positive and Negative Affect Schedule (PANAS) was developed as a measure of positive affect (PA) and negative affect (NA). The aim here is to examine the factor structure and concurrent validity of the Korean version of the Positive and Negative Affect Schedule (K-PANAS) in a clinical sample in Korea. Methods-K-PANAS was administered to a clinical sample in Korea. Internal consistency, test-retest reliability, and confirmatory factor analysis (CFA) were undertaken to examine the factorial structure and reliability of the K-PANAS. Results-The reliability of K-PANAS is satisfactory. CFA showed that several of the models commonly used in Western populations provided an insufficient fit. The modified model provided a more adequate fit to the data. Conclusion-The authors demonstrate that the K-PANAS has adequate psychometric properties, and that findings obtained in the West using PANAS were partially replicated.

      • SCIESSCISCOPUSKCI등재

        Relationship between Personality and Insomnia in Panic Disorder Patients

        HaeRan Na,EunHo Kang,BumHee Yu,JongMin Woo,YoulRi Kim,SeungHwan Lee,EuiJung Kim,SangYeol Lee,SangKeun Chung 대한신경정신의학회 2011 PSYCHIATRY INVESTIGATION Vol.8 No.2

        Objective-Panic disorder (PD) is frequently comorbid with insomnia, which could exacerbate panic symptoms and contribute to PD relapse. Research has suggested that characteristics are implicated in both PD and insomnia. However, there are no reports examining whether temperament and character affect insomnia in PD. Thus, we examined the relationship between insomnia and personality ch-aracteristics in PD patients. Methods-Participants were 101 patients, recruited from 6 university hospitals in Korea, who met the DSM-IV-TR criteria for PD. We as-sessed sleep outcomes using the sleep items of 17-item Hamilton Depression Rating Scale (HAMD-17)(item 4=onset latency, item 5= middle awakening, and item 6=early awakening) and used the Cloninger’s Temperament and Character Inventory-Revised-Short to assess personality characteristics. To examine the relationship between personality and insomnia, we used analysis of variance with age, sex, and severity of depression (total HAMD scores minus sum of the three sleep items) as the covariates. Results-There were no statistical differences (p>0.1) in demographic and clinical data between patients with and without insomnia. Initial insomnia (delayed sleep onset) correlated to a high score on the temperamental dimension of novelty seeking 3 (NS3)(F1,96=6.93, p=0.03). There were no statistical differences (p>0.1) in NS3 between patients with and without middle or terminal insomnia. Conclusion-The present study suggests that higher NS3 is related to the development of initial insomnia in PD and that temperament and character should be considered when assessing sleep problems in PD patients.

      • SCIESSCISCOPUSKCI등재

        Temperament Affects Sympathetic Nervous Function in a Normal Population

        Bora Kim,JaeHon Lee,EunHo Kang,BumHee Yu 대한신경정신의학회 2012 PSYCHIATRY INVESTIGATION Vol.9 No.3

        Objective-Although specific temperaments have been known to be related to autonomic nervous function in some psychiatric disorders, there are few studies that have examined the relationship between temperaments and autonomic nervous function in a normal population. In this study, we examined the effect of temperament on the sympathetic nervous function in a normal population. Methods-Sixty eight healthy subjects participated in the present study. Temperament was assessed using the Korean version of the Cloninger Temperament and Character Inventory (TCI). Autonomic nervous function was determined by measuring skin temperature in a resting state, which was recorded for 5 minutes from the palmar surface of the left 5th digit using a thermistor secured with a Velcro?? band. Pearson’s correlation analysis and multiple linear regression were used to examine the relationship between temperament and skin temperature. Results-A higher harm avoidance score was correlated with a lower skin temperature (i.e. an increased sympathetic tone; r=-0.343, p=0.004) whereas a higher persistence score was correlated with a higher skin temperature (r=0.433, p=0.001). Hierarchical linear regression analysis revealed that harm avoidance was able to predict the variance of skin temperature independently, with a variance of 7.1% after controlling for sex, blood pressure and state anxiety and persistence was the factor predicting the variance of skin temperature with a variance of 5.0%. Conclusion-These results suggest that high harm avoidance is related to an increased sympathetic nervous function whereas high persistence is related to decreased sympathetic nervous function in a normal population.

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