Radiotherapy dose de-escalation in patients with high grade non-Hodgkin lymphoma in a real-world clinical practice

Budhi Singh Yadav,Treshita Dey 대한방사선종양학회 2023 Radiation Oncology Journal Vol.41 No.4

Purpose: The standard treatment of non-Hodgkin lymphoma (NHL) comprises combined modality treatment, radiotherapy (RT), and chemotherapy with rituximab which has significantly improved both disease-free survival (DFS) and overall survival (OS). However, there is no uniformity in radiation dose usage in these patients. In this retrospective study, we compared lower radiation dose with higher in patients with aggressive NHL. Materials and Methods: From 2007 to 2017, treatment records of all high-grade NHL or diffuse large B-cell lymphoma and non-central nervous system NHL were included. We compared response rates, OS and DFS of patients who received ≤30 Gy RT to those with >30 Gy. Univariate and multivariate analyses were done to determine factors affecting prognosis, i.e., age, sex, stage, International Prognostic Index (IPI), adding rituximab, and radiation dose. Results: A total of 184 NHL patients treated with combined modality or radiation alone having complete follow-up details were analyzed. At median follow-up of 66.8 months, 5-year OS was 72.8% in high-dose group versus 69.9% in low-dose group (p = 0.772) and 5-year DFS 64.7% versus 64.1% (p = 0.871). Patients having early-stage disease receiving low dose and those with advanced disease treated with >30 Gy had better OS and DFS though not statistically significant. Adding rituximab was associated with significantly better OS and DFS irrespective of radiation dose delivered. High IPI score and omitting rituximab were the only factors that significantly worsened both OS and DFS. Acute radiation toxicities were comparable in both groups (p = 0.82). Among late toxicities, no patient developed a second malignancy and 5% died due to cardiovascular complications (p = 0.595) though only two patients (1.1%) had received thoracic radiation. Conclusion: The two groups had comparable response rates, acute toxicities, DFS and OS. This study suggests that RT dose reduction may be possible in high-grade NHL without compromising the DFS and OS.

Accelerated hypofractionated breast radiotherapy with simultaneous integrated boost: a feasibility study

Budhi Singh Yadav,Shipra Gupta,Divya Dahiya,Ankita Gupta,Arun Singh Oinam 대한방사선종양학회 2022 Radiation Oncology Journal Vol.40 No.2

Purpose: To assess the feasibility of accelerated hypofractionated radiotherapy with simultaneous integrated boost (SIB) in patients with breast cancer. Materials and Methods: A total of 27 patients after breast-conserving surgery were included in this study. Patients were planned on a four-dimensional computerized tomogram, and contouring was done using RTOG guidelines. The dose was 34 Gy/10#/2 week to the breast and 40 Gy/10#/2 week to the tumor bed as SIB with volumetric modulated arc technique. The primary endpoint was grade 2 acute skin toxicity. Doses to the organs-at-risk were calculated. Toxicities and cosmesis were assessed using RTOG/LENT/SOMA and HARVARD/NSABP/RTOG grading scales, respectively. Disease-free survival (DFS) and overall survival (OS) were calculated with Kaplan-Meier curves. Results: The mean age of the patients was 42 years. Left and right breast cancers were seen in 17 (63%) and 10 (37%) patients, respectively. The mean values of ipsilateral lung V₁₆ and contralateral lung V₅ were 16.01% and 3.74%, respectively. The mean heart doses from the left and right breast were 7.25 Gy and 4.37 Gy, respectively. The mean doses to the contralateral breast, oesophagus, and Dmax to brachial plexus were 2.64 Gy, 3.69 Gy, and 26.95 Gy, respectively. The mean value of thyroid V₂₅ was 19.69%. Grade 1 and 2 acute skin toxicities were observed in 9 (33%) and 5 (18.5%) patients, respectively. Grade 2 hyperpigmentation, edema, and induration were observed in 1 (3.7%), 2 (7.4%), and 4 (14.8%) patients, respectively. Mild breast pain and arm/shoulder discomfort were reported by 1 (3.4%) patient. The median follow-up was 51 months (range, 12 to 61 months). At four years, breast induration, edema, and fibrosis were observed in 1 (3.7%) patient. Cosmesis was excellent and good in 21 (78%) and 6 (22%) patients, respectively. Local recurrence and distant metastases occurred in 1 (3.7%) and 2 (7.4%) patients, respectively. DFS and OS at four years were 88% and 92%, respectively. Conclusion: With this radiotherapy schedule, acute and late toxicity rates were acceptable with no adverse cosmesis. Local control, DFS, and OS were good.

The Green Brand Marketing Strategies that Utilize Word of Mouth : Survey on Green Electronic Products in Indonesia

Budhi Haryanto,Santi Budiman People&Global Business Association 2016 Global Business and Finance Review Vol.21 No.2

In this study, the objective is focused to explain the relationship between the three independent variables (price fairness, green brand quality and green risk) and Words of Mouth (WOM), which is mediated by the satisfaction and trust. Sample is taken as many as 200 visitors at the Mall in Surakarta - Indonesia, who had the intention to buy liquid edge display (LED) screen TV. Of all the questionnaires returned, there are 12 questionnaires that cannot be used. By using Generalized Structured Component Analysis, the results indicate that the satisfaction and trust is significantly influenced by the price fairness, green brand quality and green risk. Also found that WOM is significantly influenced by the trust. Furthermore it is found also that WOM is not influenced by the price fairness and green brand quality and it is found too that WOM is not influenced by satisfaction.

Late-term effects of hypofractionated chest wall and regional nodal radiotherapy with two-dimensional technique in patients with breast cancer

Budhi Singh Yadav,Anshuma Bansal,Philip George KuttikatDeepak Das,Ankita Gupta,Divya Dahiya 대한방사선종양학회 2020 Radiation Oncology Journal Vol.38 No.2

Purpose: Hypofractionated radiotherapy (RT) is becoming a new standard in postoperative treatment of patients with early stage breast cancer after breast conservation surgery. However, data on hypofractionation in patients with advanced stage disease who undergo mastectomy followed by local and regional nodal irradiation (RNI) is lacking. In this retrospective study, we report late-term effects of 3 weeks post-mastectomy hypofractionated local and RNI with two-dimensional (2D) technique in patients with stage II and III breast cancer. Methods: Between January 1990 and December 2007, 1,770 women with breast cancer who were given radical treatment with mastectomy, systemic therapy and RT at least 10 years ago were included. RT dose was 35 Gy/15 fractions/3 weeks to chest wall by two tangential fields and 40 Gy in same fractions to supraclavicular fossa (SCF) and internal mammary nodes (IMNs). SCF and IMNs dose was prescribed at dmax and 3 cm depth, respectively. Chemotherapy and hormonal therapy was given in 64% and 74% patients, respectively. Late-term toxicities were assessed with the Radiation Therapy Oncology Group (RTOG) scores and LENT-SOMA scales (the Late Effects Normal Tissue Task Force-Subjective, Objective, Management, Analytic scales). Results: Mean age was 48 years (range, 19 to 75 years). Median follow-up was 12 years (range, 10 to 27 years). Moderate/marked arm/shoulder pain was reported by 254 (14.3%) patients. Moderate/marked shoulder stiffness was reported by 219 (12.3%) patients. Moderate/marked arm edema was seen in 131 (7.4%) patients. Brachial plexopathy was not seen in any patient. Rib fractures were noted in 6 (0.3%) patients. Late cardiac and lung toxicity was seen in 29 (1.6%) and 23 (1.3%) patients, respectively. Second malignancy developed in 105 (5.9%) patients. Conclusion: RNI with 40 Gy/15 fractions/3 weeks hypofractionation with 2D technique seems safe and comparable to historical data of conventional fractionation (ClinicalTrial.gov Registration No. NCT04175821).

Control and Monitoring Process Industrial Automation based on SCADA system using Android Smartphone

Prayoga Budhi(프라요가 부디),Isnanto(이스난도),Jeong-Hun Kim(김정훈),Sung-Jun Park(박성준) 전력전자학회 2013 전력전자학술대회 논문집 Vol.2013 No.7

Trainees’ perceptions and expectations of formal academic mentoring during the COVID-19 pandemic in Indonesian cardiology residency programs

Sunu Budhi Raharjo,Rita Mustika,Aida Lydia,Mefri Yanni,Heru Sulastomo,Rahma Tsania Zhuhra,Celly Anantaria Atmadikoesoemah 한국보건의료인국가시험원 2021 보건의료교육평가 Vol.18 No.-

Purpose: During medical residency programs, physicians develop their professional identities as specialists and encounter high expectations in terms of achieving competencies. The responsibilities of medical trainees include caring for patients, balancing work with personal life, and weathering stress, depression, and burnout. Formal academic mentoring programs strive to ease these burdens. The coronavirus disease 2019 (COVID-19) pandemic has altered the trainee–academic mentor relationship, and solutions are needed to address these challenges. The present study aimed to evaluate the formal academic mentoring process through trainees’ perceptions and expectations of formal mentoring programs during COVID-19 in Indonesian cardiology residency programs. Methods: This cross-sectional study used a self-administered online questionnaire to capture trainees’ perceptions and expectations regarding academic mentoring programs in 3 cardiology residency programs in Indonesia from October to November 2020. The questionnaire was developed before data collection. Perceptions of the existing mentoring programs were compared with expectations. Results: Responses were gathered from 169 out of 174 residents (response rate, 97.3%). Most trainees reported having direct contact with COVID-19 patients (88.82%). They stated that changes had taken place in the mode and frequency of communication with their academic advisors during the pandemic. Significant differences were found between trainees’ perceptions of the existing mentoring programs and their expectations for academic mentoring programs (P<0.001). Conclusion: Despite the challenges of interacting with their academic mentors, trainees still perceived academic mentors as a vital resource. Study programs need to consider trainees’ expectations when designing academic mentoring programs.

Enhancing the catalytic performance and coke reduction using low-cost Ni-based promoted catalyst for hydrogen production

Yogi Wibisono Budhi,Fitri Az Zahra,Wulan Reyhana,Salma Liska,Intan Clarissa Sophiana,Elvi Restiawaty,Manabu Miyamoto,Shigeyuki Uemiya,Norikazu Nishiyama 한국공업화학회 2023 Journal of Industrial and Engineering Chemistry Vol.128 No.-

Dry reforming of methane (DRM) is a highly promising reforming technology that facilitates convertingCO2-rich natural gas into synthesis gas. However, the commercial application of DRM has concerns suchas carbon deposition and sintering of the catalyst at high temperatures, leading to catalyst deactivation. This study aimed to determine the effect of an alkaline promoter addition on the amount of carbondeposited and activity test of alkaline-promoted nickel-based catalysts. Alkaline-promoted nickelbasedcatalysts were prepared using the incipient wetness impregnation method, followed by characterizationusing X-ray diffraction, N2 physisorption, H2-TPR, CO2-TPD, and thermogravimetric analysis. Theperformances of the catalysts were tested in a fixed-bed reactor under atmospheric pressure at 700 C for240 min. The Mg-promoted catalyst yielded the highest CH4 conversion (78%), CO2 conversion (64%), andH2 to CO ratio (1.52) compared to the non-promoted nickel-based and other alkaline-promoted catalysts. Furthermore, the thermogravimetric analysis revealed the Mg and Na-promoted catalyst produced 1.2and 3.5 times less carbon than a commercial steam reforming catalyst.

Innovative and intensified technology for the biological pretreatment of agro waste for ethanol production

Rajarathinam Ravikumar,Budhi Venkatesan Ranganathan,Kanchana Nandanan Chathoth,Sriramulu Gobikrishnan 한국화학공학회 2013 Korean Journal of Chemical Engineering Vol.30 No.5

Lignocellulosic biomass is an abundant, renewable resource, but the structural and chemical complexity of biomass acts as a hindrance in its effective utilization for cellulosic ethanol production. Hence, effective pretreatment is always necessary to remove the surrounding matrix of lignin prior to the enzymatic hydrolysis. Pretreatment of rice straw by Pleurotus florida was found to be effective and resulted in 49% lignin degradation, whereas fungus along with grape leaves resulted in 99% lignin degradation. This method not only explores a pathway for utilizing the solid agro waste but also results in a value-added product of edible mushrooms that has proved to be the best pretreatment technology for ethanol production. FTIR and SEM analysis confirmed the structural transformation taking place during the pretreatment. The components of grape leaves were also analyzed using GC-MS.

Odoo Data Mining Module Using Market Basket Analysis

Yulia, Yulia,Budhi, Gregorius Satia,Hendratha, Stefani Natalia The Korea Institute of Information and Commucation 2018 Journal of information and communication convergen Vol.16 No.1

Odoo is an enterprise resource planning information system providing modules to support the basic business function in companies. This research will look into the development of an additional module at Odoo. This module is a data mining module using Market Basket Analysis (MBA) using FP-Growth algorithm in managing OLTP of sales transaction to be useful information for users to improve the analysis of company business strategy. The FP-Growth algorithm used in the application was able to produce multidimensional association rules. The company will know more about their sales and customers' buying habits. Performing sales trend analysis will give a valuable insight into the inner-workings of the business. The testing of the module is using the data from X Supermarket. The final result of this module is generated from a data mining process in the form of association rule. The rule is presented in narrative and graphical form to be understood easier.

Automatic Classification of Sunspot Groups for Space Weather Analysis

Rudy Adipranata,Gregorius Satia Budhi,Bambang Setiahadi 보안공학연구지원센터 2013 International Journal of Multimedia and Ubiquitous Vol.8 No.3