The role of reactive oxygen species in methamphetamine self-administration and dopamine release in the nucleus accumbens : ROS in METH-taking behavior

Jang, Eun Young,Yang, Chae Ha,Hedges, David M.,Kim, Soo Phil,Lee, Jun Yeon,Ekins, Tyler G.,Garcia, Brandon T.,Kim, Hee Young,Nelson, Ashley C.,Kim, Nam Jun,Steffensen, Scott C. Wiley Blackwell (Blackwell Publishing) 2017 Addiction Biology Vol.22 No.5

Modeling Brand Equity for Lifestyle Brand Extensions

Eun Young Kim,Lynn Brandon 한국마케팅과학회 2010 마케팅과학연구 Vol.20 No.1

Today, the fashion market challenged by a maturing retail market needs a new paradigm in the "evolution of brand" to improve their comparative advantages. An important issue in fashion marketing is lifestyle brand extension with a specific aim to meet consumers' speci fic needs for their changing lifestyle. For fashion brand extensions into li festyle product categorics, Gen Y and Baby Boomer are emerging as "prospects"-Baby Boomers who are renovating their lifestyle, and generation Y cxperiencing changes in their life stage-with demands for buying new products. Therefore, it i imperative that apparel companies pay special attention to the consumer cohort for brand extension to create and manage their brand equity in a new product category. The purposes of this study are to (a) evaluate brand equity between parent and extension brands: (b) identify consumers' perceived marketing elements for brand extension: and (c) estimate a structural equation model for examining causative relationship bet\,yeen marketing elements and brand equity for brand extensions in lifestyle product category including home fashion items for the selected two groups (e.g., Gen Y, and Baby boomer). For theoretical frameworks, this study focused on the traditional marketing 4P's mix to identify what marketing element is more impOltantly related to brand extension equity for this study. It is assumed that comparable marketing capability can be critical to establish "brand extension equity", leads to successfully entering the new categories. Drawing tram the relevant literature, this study developed research hypotheses incorporating brand equity factors and marketing elements by focusing on the selected consumers (e.g., Gen Y, Baby Boomer). In the context of brand extension in the lifestyle products, constructs of brand equity consist of brand awareness/association, brand perceptions (e.g., perceived quality, emotional value) and brand resonance adapted trom eBBE factors (Keller, 200 I). It is postulated that the marketing elements create brand extension equity in telms of brand awareness/association, brand perceptions by the brand extension into lifestyle products, which in turn influence brand resonance. For data collection, the sample was comprised of Korean fcmale consumers in Gen Y and Baby Boomer consumer categories who have a high demand for lifestyle products due to changing their Ii fecyclcs. A total of 651 usable questionnaires were obtained from female consumers of Gen Y (n=326) and Baby Boomer (n=325) in South Korea. StlUctural and measurement models using a con'elation matrix was estimated using L1SREL 8.8. Findings indicated that perceived marketing elements for brand extension consisted of three factors: price/store image, product, and adveltising. In the model of Gen Y consumers price/store image had a positive effect on brand equity factor~(e.g., brand awareness/association, perceived quality), while product had positive effect on emotional value in the brand extensions; and the brand awareness/association was likely to increase the perceived quality and emotional value, leading to brand resonance for brand extensions in the lifestyle products. In the model of Baby Boomer consumers, price/store image had a positive effect on perceived quality, which created brand resonance of brand extension; and product had a positive effect on perceived quality and emotional value, which leads to brand resonance for brand extension in the lifestyle products. However, adveltising was negatively related to brand equity for both groups. This study provides an insight for fashion marketers 111 developing a successful brand extension strategy, leading to a sustainable competitive advantage. This study complements and extends prior works in the brand extension through critical factors of marketing efforts that affect brand extension success.

Modeling Brand Equity for Lifestyle Brand Extensions: A Strategic Approach into Generation Y vs. Baby Boomer

Kim, Eun-Young,Brandon, Lynn Korean Academy of Marketing Science 2010 마케팅과학연구 Vol.20 No.1

Today, the fashion market challenged by a maturing retail market needs a new paradigm in the "evolution of brand" to improve their comparative advantages. An important issue in fashion marketing is lifestyle brand extension with a specific aim to meet consumers' specific needs for their changing lifestyle. For fashion brand extensions into lifestyle product categories, Gen Y and Baby Boomer are emerging as "prospects"-Baby Boomers who are renovating their lifestyle, and generation Y experiencing changes in their life stage-with demands for buying new products. Therefore, it is imperative that apparel companies pay special attention to the consumer cohort for brand extension to create and manage their brand equity in a new product category. The purposes of this study are to (a) evaluate brand equity between parent and extension brands; (b) identify consumers' perceived marketing elements for brand extension; and (c) estimate a structural equation model for examining causative relationship between marketing elements and brand equity for brand extensions in lifestyle product category including home fashion items for the selected two groups (e.g., Gen Y, and Baby boomer). For theoretical frameworks, this study focused on the traditional marketing 4P's mix to identify what marketing element is more importantly related to brand extension equity for this study. It is assumed that comparable marketing capability can be critical to establish "brand extension equity", leads to successfully entering the new categories. Drawing from the relevant literature, this study developed research hypotheses incorporating brand equity factors and marketing elements by focusing on the selected consumers (e.g., Gen Y, Baby Boomer). In the context of brand extension in the lifestyle products, constructs of brand equity consist of brand awareness/association, brand perceptions (e.g., perceived quality, emotional value) and brand resonance adapted from CBBE factors (Keller, 2001). It is postulated that the marketing elements create brand extension equity in terms of brand awareness/association, brand perceptions by the brand extension into lifestyle products, which in turn influence brand resonance. For data collection, the sample was comprised of Korean female consumers in Gen Y and Baby Boomer consumer categories who have a high demand for lifestyle products due to changing their lifecycles. A total of 651 usable questionnaires were obtained from female consumers of Gen Y (n=326) and Baby Boomer (n=325) in South Korea. Structural and measurement models using a correlation matrix was estimated using LISREL 8.8. Findings indicated that perceived marketing elements for brand extension consisted of three factors: price/store image, product, and advertising. In the model of Gen Y consumers, price/store image had a positive effect on brand equity factors (e.g., brand awareness/association, perceived quality), while product had positive effect on emotional value in the brand extensions; and the brand awareness/association was likely to increase the perceived quality and emotional value, leading to brand resonance for brand extensions in the lifestyle products. In the model of Baby Boomer consumers, price/store image had a positive effect on perceived quality, which created brand resonance of brand extension; and product had a positive effect on perceived quality and emotional value, which leads to brand resonance for brand extension in the lifestyle products. However, advertising was negatively related to brand equity for both groups. This study provides an insight for fashion marketers in developing a successful brand extension strategy, leading to a sustainable competitive advantage. This study complements and extends prior works in the brand extension through critical factors of marketing efforts that affect brand extension success. Findings support a synergy effect on leveraging of fashion brand extensions (Aaker and Keller, 1990; Tauber, 1988; Shine et a 今天, 受到成熟零?市?挑?的??市?需要新的 "品牌?展" 典范?提高他?的????. ??市?的一?重要??是??足消?者由于生活方式的?化而?生的特?需求所?行的生活方式品牌??. ??品牌??到生活方式?品??, Y世代和??潮可以?是新?的 "前景"(??潮的消?者正在改?他?的生活方式. Y世代正??着他?生命?段的?化). 他?有??新?品的需求. 因此, 服?公司?品牌??注重消?群?而在新的?品??中建立和管理他?的品牌??是??的. 本文的?究目的是(a)??母品牌和子品牌的品牌??. (b)?定消?者?品牌??的感知??因素. (c)??????的群?(Y世代和??潮)的??因素和??到生活方式的?品??(包括家居???品)品牌的品牌??之?因果?系的??方程模型. ?于理??架, 本文?注??的??4P?合??定????因素在品牌????方面更重要. 比???可以建立 "品牌????", ?而成功的?入新??. 借?相?的文?, 通??注??的消?者(Y世代, ??潮), 本?究?展的?究假??合了品牌??因子和??因素. 在品牌??至生活方式?品的背景下, 品牌??的?念包括品牌?知/?合, 品牌感知(例如感知?量, 情感价?)和?CBBE因子(Keller, 2001)中而?的品牌共?. 据推?, 通?品牌??至生活方式?品, 市???要素在品牌?知/?合, 品牌感知方面?建品牌????, ?而影?品牌的共?. ?了收集?据, ?本由??Y世代的女性消?者和在??潮中出生的消?者. ?些在??潮中出生的消?者由于生活周期的改?而?生活方式?品有?高的需求. 在??Y世代(n=326)和??潮(n=325)的女性消?者中共有651?有用的?卷被使用. 我?用LISREL8.8??了使用相?矩?的??和?量模型. ?果?示品牌??的感知??因素包括三?因子: 价格/店?形象, ?品和?告. 在Y世代的模型中, 价格/店?形象?品牌??因素有??的影?(例如品牌?知/?合, 感知?量). 同?, 在品牌??中?品?情感价?有??的影?. 品牌?知/?合有可能提高感知?量和情感价?, ?而???至生活方式???的品牌?生品牌共?. 在??潮消?者模型中, 价格/店?形象?感知?量有??的影?, 感知?量可以?造品牌??的品牌共?. ?品??量感知和情感价?有正的影?, ?些都?消?者?生???至生活方式?品的品牌的品牌共?. 但是, 在???群?中?告和品牌??都是?相?. 本?究?????者提供了?展成功的品牌???略以及可持?的????的?解. 本?究?充和?展了先前的有?通???努力的因素促使品牌??成功的?究. ?究?果支持??入新的?品??, ??品牌??(Aaker and Keller, 1990; Tauber, 1998; Shine et al., 2007; Pitta and Katsanis, 1995)和??行?的增效作用. 因此, 我?推???者同???Y世代和??潮一代通??准化的??推??入新?品??(例如家具)可以降低??成本. ????者可以(a)提供高价的?品?. (b)在??通?零?渠道(例如??百?商店)强?高?特征的商店形象定位. (c)?合服??生活方式?品包括新?的款式和???的限量版. ?品牌??,成功品牌延伸的??是消?者的品牌?知度和品牌?合,?保新?品??的品牌特征. ?于??者??, 在?入新?品??的?候知道什?有助于更具?的?合是必要的. ???品牌而言, 品牌??的第二???是?入 "奢侈" 生活方式新?品??的途?. 更高的价格或店?形象都??量感知有影?.

PROCEEDINGS (2) : Sport Biomechanics ; Effects of a lower - Body Compression Garment on Warm - up Time and Jump Performance

(Jae Kun Shim),(Brandon K . Doan),(Robert U . Newton),(Young Hoo Kwon) 한국체육학회 2001 The 2001 Seoul International Sport Science Congres Vol.- No.-

Reciprocal influences of dissolved organic matter and nanosized zero-valent iron in aqueous media

Kim, Cheolyong,Chin, Yu-Ping,Ahn, Jun-Young,Wei-Haas, Maya,McAdams, Brandon,Hwang, Inseong Elsevier 2018 CHEMOSPHERE - Vol.193 No.-

<P><B>Abstract</B></P> <P>We investigated concurrent effects between nano-sized zero-valent iron (NZVI) and dissolved organic matter (DOM). Specific UV absorbance of DOM revealed that aromatic/hydrophobic moieties of DOM were bounded to NZVI surfaces. The DOM fluorescence emission peak shifted toward lower wavelength after NZVI exposure, which indicated removal of aromatic DOM fractions. This blue shift of the emission peak also attributes to the reduction of electron acceptors through NZVI-DOM charge transfer complexes. High molecular weight (10<SUP>3</SUP>–10<SUP>4</SUP> Da) DOM fractions, which are suspected to be both aromatic and hydrophobic, were removed. X-ray absorption spectroscopy (XAS) elucidated that Fe(0) content in the 30-d aged NZVI in the presence of DOM (61.6%) was substantially higher than that in the absence of DOM (25.0%). Corrosion and oxidation of NZVI were mitigated due to interruption of electron transfer by surface bounded DOM and stabilization of Fe(II) by Fe-DOM complexes. The XAS also revealed that the evolution of the iron (oxyhydr)oxide shell of NZVI was significantly altered by complexed aromatic DOM.</P> <P><B>Highlights</B></P> <P> <UL> <LI> NZVI surface preferentially sorbs aromatic/high molecular weight moieties of DOM. </LI> <LI> DOM sorption mitigates rapid oxidation of NZVI by water. </LI> <LI> DOM sorption significantly alters the evolution of NZVI shell structure. </LI> <LI> Fe(0) core of NZVI reduces DOM to interrupt intermolecular charge transfer. </LI> <LI> Interactions between NZVI and DOM can substantially affect remediation processes. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>

Direct reprogramming into endothelial cells: a new source for vascular regeneration

Lee, Sangho,Kim, Jin Eyun,Johnson, Brandon AL,Andukuri, Adinarayana,Yoon, Young-Sup Future Medicine 2017 Regenerative medicine Vol.12 No.4

Control of mammalian G protein signaling by N-terminal acetylation and the N-end rule pathway

Park, Sang-Eun,Kim, Jeong-Mok,Seok, Ok-Hee,Cho, Hanna,Wadas, Brandon,Kim, Seon-Young,Varshavsky, Alexander,Hwang, Cheol-Sang American Association for the Advancement of Scienc 2015 Science Vol.347 No.6227

<P><B>The N-end rule finds a physiological function</B></P><P>The N-end–rule pathway for protein degradation is a canonical degradation pathway discovered in the 1980s. In recent years, studies have focused on finding novel variant pathways of N-end recognition. The “classical” pathway is blocked by N-terminal acetylation of the substrate. However, in yeast, N-terminal acetylation need not block degradation, because a second pathway can act on acetylated N-termini. But is this alternate pathway a major player in the physiology of mammals? Park <I>et al.</I> now confirm the existence of the alternate pathway in mammalian cells. Most notably, patient-derived point mutations thought to confer hypertension in humans affect susceptibility to this pathway for the encoded protein substrate, Rgs2.</P><P><I>Science</I>, this issue p. 1249</P><P>Rgs2, a regulator of G proteins, lowers blood pressure by decreasing signaling through Gα<SUB>q</SUB>. Human patients expressing Met-Leu-Rgs2 (ML-Rgs2) or Met-Arg-Rgs2 (MR-Rgs2) are hypertensive relative to people expressing wild-type Met-Gln-Rgs2 (MQ-Rgs2). We found that wild-type MQ-Rgs2 and its mutant, MR-Rgs2, were destroyed by the Ac/N-end rule pathway, which recognizes N<SUP>α</SUP>-terminally acetylated (Nt-acetylated) proteins. The shortest-lived mutant, ML-Rgs2, was targeted by both the Ac/N-end rule and Arg/N-end rule pathways. The latter pathway recognizes unacetylated N-terminal residues. Thus, the Nt-acetylated Ac-MX-Rgs2 (X = Arg, Gln, Leu) proteins are specific substrates of the mammalian Ac/N-end rule pathway. Furthermore, the Ac/N-degron of Ac-MQ-Rgs2 was conditional, and Teb4, an endoplasmic reticulum (ER) membrane-embedded ubiquitin ligase, was able to regulate G protein signaling by targeting Ac-MX-Rgs2 proteins for degradation through their N<SUP>α</SUP>-terminal acetyl group.</P>

A comparison between DASL and Affymetrix on probing the whole-transcriptome

정재식,Robert Audet,Jenny Chang,Helen Wong,Scooter Willis,Brandon Young,Susan Edgerton,Ann Thor,George Sledge,Renata Duchnowska,Jacek Jassem,Krzysztof Adamowicz,Brian Leyland-Jones,Changyu Shen 한국통계학회 2016 Journal of the Korean Statistical Society Vol.45 No.1

Whole-transcriptome microarray analysis has become a popular strategy to study geneexpression in cancer, exploiting the largely available formalin-fixed paraffin-embedded (FFPE) sample resources. However, there have been relatively few comparative studies evaluating the performance of the different gene-expression array platforms. We compared two commonly used whole-transcriptome microarray platforms: Illumina human whole genome cDNA-mediated annealing, selection extension and ligation (DASL) beadchip and Affymetrix U133 Plus2 GeneChip (Affymetrix). Gene expression data based on both platforms were collected on the same total RNA extracted from FFPE tissue samples of 221 advanced breast cancer patients. Correlations between two platforms were assessed using Pearson and Spearman correlation coefficients (CCs). For both platforms we also assessed coefficient of variation, which measures relative dispersion. Finally, we compared the applicability of DASL and Affymetrix for classification of breast cancer molecular subtypes using the PAM50 classifiers. Overall, there was a statistically significant, positive gene- and patient-wise correlation between the two platforms, with stronger relationship for patient-wise CC. The relative dispersion was smaller in DASL compared to Affymetrix. The consistency in subtype classification for both microarray platforms was weak (63%). We observed weak, yet positive correlation between two platforms and different magnitudes of correlations were observed according to the metrics used.

Plant Cell and Signaling Symposium : Plant sugar sensing and signaling networks

( Jen Sheen ),( Filip Rolland ),( Wan Hsing Cheng ),( Shuichi Yanagisawa ),( Qi Hall ),( Elena Baena Gonzalez ),( Young Hee Cho ),( Sang Dong Yoo ),( Patricia Leon ),( Brandon Moore ),( Li Zhou ) 한국생화학분자생물학회 (구 한국생화학회) 2004 생화학분자생물학회 춘계학술발표논문집 Vol.2004 No.-