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      • KCI등재

        ON THE HILBERT SPACE OF FORMAL POWER SERIES

        YOUSEFI, Bahman,SOLTANI, Rahmat The Honam Mathematical Society 2004 호남수학학술지 Vol.26 No.3

        Let $\{{\beta}(n)\}^{\infty}_{n=0}$ be a sequence of positive numbers such that ${\beta}(0)=1$. We consider the space $H^2({\beta})$ of all power series $f(z)=^{Po}_{n=0}{\hat{f}}(n)z^n$ such that $^{Po}_{n=0}{\mid}{\hat{f}}(n){\mid}^2{\beta}(n)^2<{\infty}$. We link the ideas of subspaces of $H^2({\beta})$ and zero sets. We give some sufficient conditions for a vector in $H^2({\beta})$ to be cyclic for the multiplication operator $M_z$. Also we characterize the commutant of some multiplication operators acting on $H^2({\beta})$.

      • Anti-Proliferative Properties of Cornus mass Fruit in Different Human Cancer Cells

        Yousefi, Bahman,Abasi, Mozhgan,Abbasi, Mehran Mesgari,Jahanban-Esfahlan, Rana Asian Pacific Journal of Cancer Prevention 2015 Asian Pacific journal of cancer prevention Vol.16 No.14

        Background: There is a long standing interest in natural compounds especially those with a high polyphenolic content and high scavenging activity for hazardous free radicals. Cornus mas (CM) fruit is well known for its antioxidant activities; however, its toxicity against human cancers needs to be addressed. Here, we investigated selective anticancer effects of CM on different human cancer cells. Materials and Methods: A hydro-alcoholic extract of CM (HECM) was prepared and total phenolic content (TPC) and total flavonoid content (TFC) were determined by colorimetric assays. Antioxidant activity was assessed with respectto DPPH radical scavenging. MTT assays were used to evaluate the cytotoxicity of different doses of CM (0, 5, 20, 100, 250, 500, $1000{\mu}g/ml$) towards A549 (lung non small cell cancer), MCF-7 (breast adenocarcinoma), SKOV3 (ovarian cancer) and PC-3 (prostate adenocarcinoma) cells. Results: Significant (P<0.05) or very significant (P<0.001) differences were observed in comparison to negative controls at all tested doses ($5-1000{\mu}g/ml$). In all cancer cells, HECM reduced the cell viability to values below 26%, even at the lowest doses. In all cases, $IC_{50}$ was obtained at doses below $5{\mu}g/ml$. The mean growth inhibition was 81.8%, 81.9%, 81.6% and 79.3% in SKOV3, MCF-7, PC-3 and A549 cells, respectively. Conclusions: Altogether, to our best knowledge, this is a first study that evaluated toxicity of a HECM with high antioxidant activity in different human cancer cells in vitro. Our results indicated that a hydro-alcoholic extract of CM possesses high potency to inhibit proliferation of different tumor cells in a dose independent manner, suggesting that an optimal biological dose is more important and relevant than a maximally tolerated one.

      • SCIESCOPUSKCI등재

        ON THE HEREDITARILY HYPERCYCLIC OPERATORS

        Yousefi, Bahman,Farrokhinia, Ali Korean Mathematical Society 2006 대한수학회지 Vol.43 No.6

        Let X be a separable Banach space. We give sufficient conditions under which $T:X{\rightarrow}X$ is hereditarily hypercyclic. Also, we prove that hereditarily hypercyclicity with respect to a special sequence implies the hereditarily hypercyclicity with respect to the entire sequence.

      • KCI등재

        On the hereditarily hypercyclic operators

        Bahman Yousefi,Ali Farrokhinia 대한수학회 2006 대한수학회지 Vol.43 No.6

        LetX be a separable Banach space. We give sucientconditions under which T : X ! X is hereditarily hypercyclic.Also, we prove that hereditarily hypercyclicity with respect to aspecial sequence implies the hereditarily hypercyclicity with respectto the entire sequence.

      • Time - and Concentration - Dependent Effects of Resveratrol on miR 15a and miR16-1 Expression and Apoptosis in the CCRF-CEM Acute Lymphoblastic Leukemia Cell Line

        Azimi, Ako,Hagh, Majid Farshdousti,Talebi, Mehdi,Yousefi, Bahman,feizi, Abbas Ali Hossein pour,Baradaran, Behzad,Movassaghpour, Ali Akbar,Shamsasenjan, Karim,Khanzedeh, Taghi,Ghaderi, Abdol Hasan,Heyd Asian Pacific Journal of Cancer Prevention 2015 Asian Pacific journal of cancer prevention Vol.16 No.15

        Background: Chemotherapy is one of the common approaches in treatment of cancers, especially leukemia. However, drug resistance phenomena reduce the likelihood of treatment success. Resveratrol is a herbal compound which through complicated processes makes some selected cells sensitive to treatment and induction of apoptosis. In the present study, the effects of resveratrol on the expression of miR 15a and miR16-1 and apoptosis in the CCRF-CEM cell line were investigated. Materials and Methods: The CCRF-CEM cell line was cultured under standard conditions and changes in miR 15a and miR 16-1 expression were analyzed by real time-PCR technique, with attention to reveratrol dose and time dependence. Also, apoptosis is evaluated by flow cytometry using annexin V and PI. Results: CCRF-CEM cells underwent dose-dependent apoptotic cell death in response to resveratrol. MiR 15a and miR 16-1 expression was up-regulated after 24 and 48 hours resveratrol treatment (p<0.05). Conclusions: The results of our study indicate that resveratrol induces apoptosis in a time and dose-dependent manner in CCRF-CEM cells. Also, increased expression level of miR 16-1 and miR 15a by means of resveratrol in CCRF-CEM cells might have a role in apoptosis induction and predisposition. According to our results resveratrol can be regarded as a dietary supplement to improve efficacy of anti-leukemia therapies.

      • KCI등재

        Investigation of BAX and BCL2 expression and apoptosis in a resveratrol- and prednisolone-treated human T-ALL cell line, CCRF-CEM

        Taghi Khanzadeh,Majid Farshdousti Hagh,Mehdi Talebi,Bahman Yousefi,Ako Azimi,Abbas Ali Hossein pour feizi,Behzad Baradaran 대한혈액학회 2018 Blood Research Vol.53 No.1

        BackgroundThe numerous side effects and chemo-resistance of conventional chemical drugs in thetreatment of malignancies have led to consideration of the anti-cancer properties of naturalproducts. In the present study, we aimed to explore the apoptotic effect of two naturalcomponents, resveratrol and prednisolone, on the T acute lymphoblastic leukemia (ALL)cell line, CCRF-CEM. Our findings suggested the incorporation of these natural agentsinto drug regimens to treat patients with ALL. MethodsIn this study, we investigated the effect of different doses of resveratrol (15, 50 and 100μM) and prednisolone (700 μM) on BAX (apoptosis promoter) and BCL2 (apoptosis inhibitor)expressions following 24 and 48 hours of treatment on CCRF-CEM cells, usingreal-time PCR, and on apoptosis induction using flow cytometry. ResultsThe results showed a time- and dose-dependent increase in BAX expression and a decreasein BCL2 expression. Apoptosis was induced in CCRF-CEM cells treated with resveratroland prednisolone for 24 and 48 hours. Combined resveratrol and prednisolone treatmentshowed synergistic effects on the overexpression of BAX and the downregulationof BCL2. The drug combination had a greater influence on apoptosis induction comparedwith either drug administered alone after 48 hours of treatment. ConclusionThe results of this study suggested that resveratrol exhibited a remarkable efficacy to improvethe influence of glucocorticoids drugs, especially prednisolone, to induce apoptosisin the CCRF-CEM cell line.

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