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RISS 인기검색어
- 검색키워드
- 저자 : Bafna, Pallavi (검색결과 5 건)
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Effect of Cynodon dactylon on rotenone induced Parkinson's disease
Sharma, Neha,Bafna, Pallavi 경희한의학연구센터 2012 Oriental Pharmacy and Experimental Medicine Vol.12 No.3
In the present study, the aqueous extract of Cynodon dactylon (AECD) Pers. (Graminae) was evaluated for anti-parkinson's activity in rats.The anti-parkinson's effect of AECD was studied against rotenone (2 mg/kg, s.c.) - induced parkinsons in rats. In this study, chronic administration of rotenone in rats (28 days) produced motor dysfunctions like catalepsy and muscle rigidity along with a reduction in locomotor activity. Rotenone administration was also found to generate oxidative stress in the brain as evident from an increase in the level of TBARS and decrease in the levels of SOD and GSH. Pretreatment with AECD resulted in a significant (p<0.001) decrease in catalepsy and muscle rigidity along with a significant (p<0.001) increase in locomotion as compared to the rotenone-treated control group. AECD treated rats also showed a reduction in the TBARS level and an increase in the GSH, SOD and CAT levels; thus reducing the oxidative stress in the brain of animals. The study thus proved that Cynodon dactylon treatment significantly attenuated the motor defects and also protected the brain from oxidative stress, both induced by rotenone. These results strongly indicate the possible therapeutic potential of Cynodon dactylon as an antioxidant in Parkinson's disease and other movement disorders.
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Anti-ulcer and antioxidant activity of leaves of Madhuca indica in rats
GU Chidrewar,JH Tanavade,SH Deshpande,PS Vartak,JB Shah,NP Patel,CR Patadiya,PA Bafna 경희대학교 융합한의과학연구소 2010 Oriental Pharmacy and Experimental Medicine Vol.10 No.1
The leaves of Madhuca (M.) indica J.f.Gmel. (Sapotaceae) have been used traditionally in folk medicine due to its astringent properties and are effective in treatment of eczema and snake bites. Methanolic extract of M. indica is rich in tannins and has been proven experimentally to possess antibacterial activity. The present study was undertaken to evaluate the anti-ulcer and antioxidant activity of M. indica in rats. The methanolic extract of leaves of M. indica was tested at various doses (75, 150 and 300 mg/kg, p.o.) for its effect on gastric secretion and gastric ulcers in pylorus-ligation and on ethanol- induced gastric mucosal injury in rats. The significant reduction in ulcer index in both the models along with an increase in the pH of the gastric fluid and mucin content of stomach, and the acid secretory parameters such as total acidity and volume of gastric fluid were also significantly reduced along with reduction in the pepsin activity in pylorus-ligated rats proved the anti-ulcer activity of M. indica. The increase in the levels of superoxide dismutase, catalase and reduced glutathione and decrease in lipid peroxidation in both the models proved the antioxidant activity of M. indica. Thus it can be concluded that M. indica possesses anti-ulcer activity, which can be attributed to its antioxidant mechanism of action.
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ARID1B, a molecular suppressor of erythropoiesis, is essential for the prevention of Monge’s disease
Azad Priti,Caldwell Andrew B.,Ramachandran Srinivasan,Spann Nathanael J.,Akbari Ali,Villafuerte Francisco C.,Bermudez Daniela,Zhao Helen,Poulsen Orit,Zhou Dan,Bafna Vineet,Subramaniam Shankar,Haddad G 생화학분자생물학회 2022 Experimental and molecular medicine Vol.54 No.-
At high altitude Andean region, hypoxia-induced excessive erythrocytosis (EE) is the defining feature of Monge’s disease or chronic mountain sickness (CMS). At the same altitude, resides a population that has developed adaptive mechanism(s) to constrain this hypoxic response (non-CMS). In this study, we utilized an in vitro induced pluripotent stem cell model system to study both populations using genomic and molecular approaches. Our whole genome analysis of the two groups identified differential SNPs between the CMS and non-CMS subjects in the ARID1B region. Under hypoxia, the expression levels of ARID1B significantly increased in the non-CMS cells but decreased in the CMS cells. At the molecular level, ARID1B knockdown (KD) in non-CMS cells increased the levels of the transcriptional regulator GATA1 by 3-fold and RBC levels by 100-fold under hypoxia. ARID1B KD in nonCMS cells led to increased proliferation and EPO sensitivity by lowering p53 levels and decreasing apoptosis through GATA1 mediation. Interestingly, under hypoxia ARID1B showed an epigenetic role, altering the chromatin states of erythroid genes. Indeed, combined Real-time PCR and ATAC-Seq results showed that ARID1B modulates the expression of GATA1 and p53 and chromatin accessibility at GATA1/p53 target genes. We conclude that ARID1B is a novel erythroid regulator under hypoxia that controls various aspects of erythropoiesis in high-altitude dwellers.
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Anti-ulcer and antioxidant activity of leaves of Madhuca indica in rats
Chidrewar, G.U.,Tanavade, J.H.,Deshpande, S.H.,Vartak, P.S.,Shah, J.B.,Patel, N.P.,Patadiya, C.R.,Bafna, P.A. Kyung Hee Oriental Medicine Research Center 2010 Oriental pharmacy and experimental medicine Vol.10 No.1
The leaves of Madhuca (M.) indica J.f.Gmel. (Sapotaceae) have been used traditionally in folk medicine due to its astringent properties and are effective in treatment of eczema and snake bites. Methanolic extract of M. indica is rich in tannins and has been proven experimentally to possess antibacterial activity. The present study was undertaken to evaluate the anti-ulcer and antioxidant activity of M. indica in rats. The methanolic extract of leaves of M. indica was tested at various doses (75, 150 and 300 mg/kg, p.o.) for its effect on gastric secretion and gastric ulcers in pylorus-ligation and on ethanol- induced gastric mucosal injury in rats. The significant reduction in ulcer index in both the models along with an increase in the pH of the gastric fluid and mucin content of stomach, and the acid secretory parameters such as total acidity and volume of gastric fluid were also significantly reduced along with reduction in the pepsin activity in pylorusligated rats proved the anti-ulcer activity of M. indica. The increase in the levels of superoxide dismutase, catalase and reduced glutathione and decrease in lipid peroxidation in both the models proved the antioxidant activity of M. indica. Thus it can be concluded that M. indica possesses anti-ulcer activity, which can be attributed to its antioxidant mechanism of action.
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