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BHOSALE PRITAM BHAG-WAN,하상은,김훈환,아부살리야 아부야시르,박민영,김곤섭,Kim Jin-A 대한독성 유전단백체 학회 2023 Molecular & cellular toxicology Vol.19 No.3
Background Iridin is a glycoside form of fl avonoids isolated from Belamcanda chinensis , and Iris fl orentina has numerous biological properties, including antitumor, antiproliferative, anti-infl ammatory and antioxidant properties. Infl ammatory diseases are an essential health concern and have a growing incidence worldwide, so developing safe drugs remains an important objective. Objective In the present study, we evaluated iridin's anti-infl ammatory eff ect on LPS-stimulated skeletal muscle cells (L6). The anti-infl ammatory action of iridin elucidated through NF-κB (nuclear factor-kappa B) and MAPK (mitogen-activated protein kinases) pathway in LPS-stimulated L6 cells. Results Determination of cytotoxicity was examined by MTT assay. The expression level of cyclooxygenase-2 (COX-2) and nitric oxide synthase (iNOS) was evaluated by western blot analysis. To elucidate the underlying mechanism, NF-κB and MAPKs proteins were investigated by immunoblot. Iridin could decrease the phosphorylation of NF-κB and MAPK proteins in LPS-induced L6 cells. Conclusion The results showed that iridin inhibited the phosphorylation of NF-κB and MAPK proteins and infl ammatory cytokines COX-2 and iNOS in LPS-induced L6 cells. Based on fi ndings in this work, iridin possesses anti-infl ammatory action on L6 cells and could be considered for an attractive candidate for anti-infl ammation.
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Glycosidic flavonoids and their potential applications in cancer research: a review
Abusaliya Abuyaseer,하상은,BHOSALE PRITAM BHAG-WAN,김훈환,박민영,베트리벨 프리티,김곤섭 대한독성 유전단백체 학회 2022 Molecular & cellular toxicology Vol.18 No.1
Purpose of review Every year, the cancer patient registry increases, and the leading cause of death in a global context. Plantbased molecules are gaining attention in cancer research due to the side effects of chemotherapy. A glycosidic derivative of flavonoid (GDF) plays a significant role in cancer proliferation mechanisms. GDF inhibits cell proliferation by elevating the expression of apoptotic proteins, altering the expression of nuclear factor-kappa B (NF- κB), and decreasing mitochondrial membrane potential (Δψm) in cancer cells. Recent findings Reported studies on the flavonoids orientin, vitexin, prunetionoside, chrysin, and scutellarein increased attention and are being widely investigated for their potential role in different parts of cancer research. Prunetionoside is a flavonoid with high cytotoxic potential and capable of inducing necroptosis in AGS gastric cancer cells. Similarly, scutellarein is a flavonol, induces an extrinsic apoptotic pathway and downregulates the expression level of cyclin proteins in HepG2 liver cancer cells. Vitexin is reported to be capable of deregulating the expression levels of p-Akt, p-mTOR, and p-PI3K in A549 lung cancer cells. Orientin inhibits IL-8 expression and invasion in MCF-7 breast cancer cells by suppressing MMP-9 in the presence of TPA via STAT3/AP-1/ERK/PKCα-mediated signaling pathways. It also induces mitochondria-mediated intrinsic apoptosis and G0/G1 cell cycle arrest in HT29 colon cancer cells. Chrysin is a flavonoid present in honey that has been shown to play an important role in cervical and colon cancer by suppressing the AKT/mTOR/PI3K pathway and increasing ROS accumulation, LDH leakage, respectively.
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