Effect of an herbal formulation on DOCA-salt and fructose induced models of hypertension in rats

Athare, CL,Mohan, M,Kasture, SB Kyung Hee Oriental Medicine Research Center 2008 Oriental pharmacy and experimental medicine Vol.8 No.4

The present study was carried out to investigate the antihypertensive effect of a folklore herbal formulation (HF) (300mg/kg/day; p.o.) in deoxycorticosterone acetate (DOCA)-salt induced and fructose induced hypertensive rats. In DOCA model, DOCA (15 mg/kg, s.c., twice a week) was administered to unilateral nephrectomized rats for 4 weeks. In fructose model, drinking water was replaced with 10% fructose solution for 6 weeks to induce hypertension. Systolic blood pressure (BP) was measured once every week during the treatment schedule. After completion of treatment schedule, BP and vascular reactivity to various agonists like Noradrenaline, Adrenaline, Phenylephrine and Serotonin (5-hydroxytrptamine; 5-HT) were recorded in rats of both models. A cumulative concentration response curve of 5-HT was carried out in isolated rat fundus strip of the DOCA-salt induced and fructose induced hypertensive rats. The results tend to suggest that HF possesses antihypertensive activity.

Effect of an herbal formulation on DOCA-salt and fructose induced models of hypertension in rats

CL Athare,M Mohan,SB Kasture 경희대학교 융합한의과학연구소 2008 Oriental Pharmacy and Experimental Medicine Vol.8 No.4

The present study was carried out to investigate the antihypertensive effect of a folklore herbal formulation (HF) (300mg/kg/day; p.o.) in deoxycorticosterone acetate (DOCA)-salt induced and fructose induced hypertensive rats. In DOCA model, DOCA (15 mg/kg, s.c., twice a week) was administered to unilateral nephrectomized rats for 4 weeks. In fructose model, drinking water was replaced with 10% fructose solution for 6 weeks to induce hypertension. Systolic blood pressure (BP) was measured once every week during the treatment schedule. After completion of treatment schedule, BP and vascular reactivity to various agonists like Noradrenaline, Adrenaline, Phenylephrine and Serotonin (5-hydroxytrptamine; 5-HT) were recorded in rats of both models. A cumulative concentration response curve of 5-HT was carried out in isolated rat fundus strip of the DOCA-salt induced and fructose induced hypertensive rats. The results tend to suggest that HF possesses antihypertensive activity. The present study was carried out to investigate the antihypertensive effect of a folklore herbal formulation (HF) (300mg/kg/day; p.o.) in deoxycorticosterone acetate (DOCA)-salt induced and fructose induced hypertensive rats. In DOCA model, DOCA (15 mg/kg, s.c., twice a week) was administered to unilateral nephrectomized rats for 4 weeks. In fructose model, drinking water was replaced with 10% fructose solution for 6 weeks to induce hypertension. Systolic blood pressure (BP) was measured once every week during the treatment schedule. After completion of treatment schedule, BP and vascular reactivity to various agonists like Noradrenaline, Adrenaline, Phenylephrine and Serotonin (5-hydroxytrptamine; 5-HT) were recorded in rats of both models. A cumulative concentration response curve of 5-HT was carried out in isolated rat fundus strip of the DOCA-salt induced and fructose induced hypertensive rats. The results tend to suggest that HF possesses antihypertensive activity.

GeV to TeV astrophysical tau neutrinos

Athar, H.,Kim, C.S. Elsevier 2004 Physics letters: B Vol.598 No.1

<P><B>Abstract</B></P><P>Neutrinos with energy greater than GeV are copiously produced in the p(A,p) interactions occurring in several astrophysical sites such as (i) the Earth atmosphere, (ii) our galactic plane as well as in (iii) the galaxy clusters. A comparison of the tau and mu neutrino flux in the presence of neutrino oscillations from these three representative astrophysical sites is presented. It is pointed out that the non-atmospheric tau neutrino flux starts dominating over the downward going atmospheric tau neutrino flux for neutrino energy <I>E</I> as low as ∼10GeV. This energy value is much lower than the energy value, E⩾5×<SUP>104</SUP>GeV, estimated for the dominance of the non-atmospheric mu neutrino flux, in the presence of neutrino oscillations. Future prospects for possible observations of non-atmospheric tau neutrino flux are briefly mentioned.</P>

Prevalence of Tobacco mosaic virus in Iran and Evolutionary Analyses of the Coat Protein Gene

Athar Alishiri,Farshad Rakhshandehroo,Hamid Reza Zamanizadeh,피터 팔루카이티스 한국식물병리학회 2013 Plant Pathology Journal Vol.29 No.3

The incidence and distribution of Tobacco mosaic virus (TMV) and related tobamoviruses was determined using an enzyme-linked immunosorbent assay on 1,926 symptomatic horticultural crops and 107 asymptomatic weed samples collected from 78 highly infected fields in the major horticultural crop-producing areas in 17 provinces throughout Iran. The results were confirmed by host range studies and reverse transcription-polymerase chain reaction. The overall incidence of infection by these viruses in symptomatic plants was 11.3%. The coat protein (CP) gene sequences of a number of isolates were determined and disclosed to be a high identity (up to 100%) among the Iranian isolates. Phylogenetic analysis of all known TMV CP genes showed three clades on the basis of nucleotide sequences with all Iranian isolates distinctly clustered in clade II. Analysis using the complete CP amino acid sequence showed one clade with two subgroups, IA and IB, with Iranian isolates in both subgroups. The nucleotide diversity within each subgroup was very low, but higher between the two clades. No correlation was found between genetic distance and geographical origin or host species of isolation. Statistical analyses suggested a negative selection and demonstrated the occurrence of gene flow from the isolates in other clades to the Iranian population.

Complications associated with intravesical migration of an intrauterine device

( Athar Rasekhjahromi ),( Zohre Chitsazi ),( Azadeh Khlili ),( Zahra Zarei Babaarabi ) 대한산부인과학회 2020 Obstetrics & Gynecology Science Vol.63 No.5

The intrauterine device (IUD) is the most common method of reversible contraception in women. However, IUD can perforate the uterus and also migrate into pelvic or abdominal organs. A 43-year-old woman with a 5-year history of IUD placement and without specific symptoms, decided to remove her IUD and undergo tubal ligation. Radiological assessment, including a pelvic X-ray and ultrasonography, revealed no copper IUD within the uterus. Retrieval attempts with cystoscopy were unsuccessful. The IUD was found embedded in the fundal part of the bladder wall and was subsequently removed through a laparotomy incision. Although there are cases in the literature that were successfully managed with cystoscopy, in chronic cases, the formation of granulation tissue may preclude retrieval of an IUD using this intervention.

An Approach for Synthesis and Characterization of Zirconia Nanopowder via Microwave Thermal Process

Athar, Taimur,Han, Sanghwan,Ko, Taegyung,Lee, Ik-Mo Taylor Francis 2009 Synthesis and reactivity in inorganic, metal-organ Vol.39 No.5

<P> We applied a simple, versatile and an efficient non-toxic methodology based on microwave irradiation process to prepare a gel from n-zirconium butoxide without using any solvent at ambient temperature to open new possibilities to control particle size distribution, surface chemistry and agglomeration. The alkoxy-derived gel changed to tetragonal zirconia powder on heating at 400°C with crystalline particles size (3 ∼ 5 nm). Zirconia exhibited strong luminescence under a UV laser. The presence of a organic moieties as impurities exhibit a strong luminescence in zirconia powder. From the structural analysis it is concluded that the morphology of the oxide strongly depends on the nature of the precursors and the synthetic methology.</P>

An Integrated Low Temperature Approach for the Synthesis of Titania via Sol-Gel process

Athar, Taimur,Han, Kyusuk,Han, Sanghwan,Ko, Taegyung,Lee, Ik-Mo Taylor Francis 2009 Synthesis and reactivity in inorganic, metal-organ Vol.39 No.5

<P> Colloidal titania particles with nanosize size distribution were prepared via sol-gel process by using oxo-titanium alkoxide as a molecular precursor. The transformation from oxo-titanium alkoxide to metal oxide was studied by IR, UV, thermal analysis, X-ray and TEM. TEM and XRD techniques were used to characterize the microstructure and crystallite morphology. The experimental results show that the titania has a good crystallinity with a particle size (5 nm), shape and with favorable surface morphology. These results support that titania has strong implications for the interaction between the oleic acid used as surfactant and Ti nanoparticle to enhance the stability with controlled functional properties.</P>

Synthesis of novel <i>N</i>-(1,3-thiazol-2-yl)benzamide clubbed oxadiazole scaffolds: Urease inhibition, Lipinski rule and molecular docking analyses

Athar Abbasi, Muhammad,Raza, Hussain,Aziz-ur-Rehman, Hussain,Zahra Siddiqui, Sabahat,Adnan Ali Shah, Syed,Hassan, Mubashir,Seo, Sung-Yum Elsevier 2019 Bioorganic chemistry Vol.83 No.-

<P><B>Abstract</B></P> <P>Present work aimed to synthesize some unique bi-heterocyclic benzamides as lead compounds for the <I>in vitro</I> inhibition of urease enzyme, followed by <I>in silico</I> studies. These targeted benzamides were synthesized in good yields through a multi-step protocol and their structures were confirmed by IR, <SUP>1</SUP>H NMR, <SUP>13</SUP>C NMR, EI-MS and elemental analysis. The <I>in vitro</I> screening results showed that most of the ligands exhibited good inhibitory potentials against the urease. Chemo-informatics analysis envisaged that all these compounds obeyed the Lipinski's rule. Molecular docking results showed that <B>7h</B> exhibited good binding energy value (−8.40 kcal/mol) and was bound within the active region of urease enzyme. From the present investigation, it was inferred that some of these potent urease inhibitors might serve as novel templates in drug designing.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Synthesis of bi-heterocyclic scaffolds. </LI> <LI> Structural characterization with spectral analysis. </LI> <LI> Urease inhibition and structure-activity relationship. </LI> <LI> Chemo-informatics and validation of Lipinski rule. </LI> <LI> Molecular docking analysis to ascertain interactions. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>

Prevalence of Tobacco mosaic virus in Iran and Evolutionary Analyses of the Coat Protein Gene

Alishiri, Athar,Rakhshandehroo, Farshad,Zamanizadeh, Hamid-Reza,Palukaitis, Peter The Korean Society of Plant Pathology 2013 Plant Pathology Journal Vol.29 No.3

The incidence and distribution of Tobacco mosaic virus (TMV) and related tobamoviruses was determined using an enzyme-linked immunosorbent assay on 1,926 symptomatic horticultural crops and 107 asymptomatic weed samples collected from 78 highly infected fields in the major horticultural crop-producing areas in 17 provinces throughout Iran. The results were confirmed by host range studies and reverse transcription-polymerase chain reaction. The overall incidence of infection by these viruses in symptomatic plants was 11.3%. The coat protein (CP) gene sequences of a number of isolates were determined and disclosed to be a high identity (up to 100%) among the Iranian isolates. Phylogenetic analysis of all known TMV CP genes showed three clades on the basis of nucleotide sequences with all Iranian isolates distinctly clustered in clade II. Analysis using the complete CP amino acid sequence showed one clade with two subgroups, IA and IB, with Iranian isolates in both subgroups. The nucleotide diversity within each subgroup was very low, but higher between the two clades. No correlation was found between genetic distance and geographical origin or host species of isolation. Statistical analyses suggested a negative selection and demonstrated the occurrence of gene flow from the isolates in other clades to the Iranian population.

Structure-activity relationship and in silico study of unique bi-heterocycles: 5-[(2-amino-1,3-thiazol-4-yl)methyl]-1,3,4-oxadiazole-2-thiol derivatives

Abbasi Athar, Muhammad,Ramzan Shahid, Muhammad,Aziz-Ur-Rehman, A,Siddiqui Zahra, Sabahat,Hassan, Mubashir,Raza, Hussain,Shah Adnan, Syed,Mirza, Bushra,Seo, Sung-Yum National Library of Serbia 2019 Journal of the Serbian Chemical Society Vol.84 No.7