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RISS 인기검색어
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- 저자 : Ashrafzadeh, Hamid Reza (검색결과 4 건)
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In Vitro Breeding of Heavy Metal-Resistant Plants: A Review
Seyedardalan Ashrafzadeh,David M.W. Leung 한국원예학회 2015 Horticulture, Environment, and Biotechnology Vol.56 No.2
Plant biotechnology using in-vitro cell and tissue culture is a practical plant breeding tool in developing plants resistant to different abiotic stresses such as cold stress and elevated soil salinity. In this study, the focus is on the in vitro breeding method applied for development of plants resistant to heavy metal (HM) stress. It consists of the following three successive stages: (i) initiation of callus cells, some of which are somaclonal variants with new traits, (ii) exposure of the calli to HMs as selective agents during proliferation for selection of somaclonal variants with enhanced HM-resistance, and (iii) selection of the desirable resistant variants following plant regeneration in the presence of HMs. The whole procedure is more efficient and cost-effective than the conventional breeding methods. Moreover, the plants developed through this approach are not regarded as genetically modified organisms (GMOs), and therefore, did not pose negative public acceptance issues unlike GM plants. However, despite the numerous advantages of this in-vitro breeding approach, it has been employed in a few plant breeding studies to generate HMresistant plants. The present study outlined the fundamental principles of in vitro breeding and the progress made so far towards development of HM-resistant plants based on this approach.
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Pouryan Hadi,KhodaBandehLou Ashkan,Hamidi Peyman,Ashrafzadeh Fedra 국제구조공학회 2023 Structural Engineering and Mechanics, An Int'l Jou Vol.86 No.2
To predict the rheological behaviours along with the compressive strength of self-compacting concrete that incorporates environmentally friendly ingredients as cement substitutes, a comparative evaluation of machine learning methods is conducted. To model four parameters, slump flow diameter, L-box ratio, V-funnel time, as well as compressive strength at 28 days-a complete mix design dataset from available pieces of literature is gathered and used to construct the suggested machine learning standards, SVM, MARS, and Mp5-MT. Six input variables-the amount of binder, the percentage of SCMs, the proportion of water to the binder, the amount of fine and coarse aggregates, and the amount of superplasticizer are grouped in a particular pattern. For optimizing the hyper-parameters of the MARS model with the lowest possible prediction error, a gravitational search algorithm (GSA) is required. In terms of the correlation coefficient for modelling slump flow diameter, Lbox ratio, V-funnel duration, and compressive strength, the prediction results showed that MARS combined with GSA could improve the accuracy of the solo MARS model with 1.35%, 11.1%, 2.3%, as well as 1.07%. By contrast, Mp5-MT often demonstrates greater identification capability and more accurate prediction in comparison to MARS-GSA, and it may be regarded as an efficient approach to forecasting the rheological behaviors and compressive strength of SCC in infrastructure practice.
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Hamidian, Saeideh,Talebi, Ali Reza,Fesahat, Farzaneh,Bayat, Mohammad,Mirjalili, Ali Mohammad,Ashrafzadeh, Hamid Reza,Rajabi, Mahya,Montazeri, Fateme,Babaei, Saeid The Korean Society for Reproductive Medicine 2020 Clinical and Experimental Reproductive Medicine Vol.47 No.1
Objective: Since sperm abnormalities are known to be a major reason for recurrent pregnancy loss (RPL), any defects in DNA structure and chromatin condensation can place embryos at risk in the early stage of development and implantation. As antioxidants such as vitamin C may play a protective role against the destruction of protamine genes in sperm chromatin, this study was conducted to evaluate the effects of vitamin C on chromatin and the expression of protamine genes in the male partners of couples with RPL. Methods: Twenty male partners of couples with RPL were selected as the intervention group and received vitamin C supplementation (250 mg daily for 3 months). Healthy fertile men (n = 20) were included as controls. Sperm chromatin, DNA integrity, and the expression levels of protamine genes were evaluated before and after treatment. Results: Significant differences were found in sperm morphology, protamine deficiency, and apoptosis between the two groups and before and after vitamin C administration. A significant change was found in mRNA levels of PRM1, PRM2, and the PRM1/PRM2 ratio after treatment. Conclusion: Daily oral administration of vitamin C may improve human sperm parameters and DNA integrity by increasing protamine gene expression levels in the male partners of couples with RPL. The beneficial effects of vitamin C supplementation as an antioxidant for the male partners of couples with RPL could lead to improved pregnancy outcomes in these cases.
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Behnam Beizaei,Farrokh Seilanian Toosi,Yousef Shahmoradi,Javad Akhondian,Farah Ashrafzadeh,Mehran Beiraghi Toosi,Shima Imannezhad,Alireza Kooshki,Ehsan Hassan Nejad,Asma Payandeh,Nahid Tavakkolizadeh 대한소아신경학회 2024 대한소아신경학회지 Vol.32 No.1
Ann Child Neurol 2024;32(1):1-7 Purpose: Idiopathic intracranial hypertension (IIH) is a clinical syndrome that mimics brain tumors with increased intracranial pressure. The present study is designed to investigate the diagnostic criteria of magnetic resonance imaging (MRI) and the severity of cerebrospinal fluid (CSF) pressure to understand the relationship and frequency of these criteria with the level of CSF pressure. Methods: The present cross-sectional study was conducted on children diagnosed with IIH between the years 2011 and 2020, who were admitted to the pediatric neurology department of Ghaem Hospital, Mashhad, Iran. Clinical manifestations and imaging findings of the patients were recorded through a checklist. Results: Forty-nine patients were included in the study; 27 (55.1%) were male, and 22 (44.9%) were female. The average CSF pressure was 40.64±20.63 cmH2O. The mean diameter distension of the perioptic subarachnoid space was 6.02±1.21 mm. Six (10.8%) patients had unilateral transverse sinus stenosis with an average CSF pressure of 20.47±36.80 cmH2O and 11 (21.4%) patients had bilateral transverse sinus stenosis with an average pressure of 48.22±21.04 cmH2O. In 22 (44.89%) patients, flattening of the posterior globe with the CSF pressure of 48.80±17.94 cmH2O was reported. Twenty-four (49%) patients had optic nerve tortuosity, with an average CSF pressure of 46.52±20.33 cmH2O. Among the diagnostic criteria, the pressure had a significant relationship with the flattening of the posterior globe (P<0.022). Conclusion: Since MRI is a non-invasive method for examining IIH, the findings of this study may aid in diagnosing and monitoring these patients.
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