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      • Matrix Converter as UPFC for Transmission line Compensation

        Anindya Dasgupta,Praveen Tripathy,Partha Sarathi Sensarma 전력전자학회 2007 ICPE(ISPE)논문집 Vol.- No.-

        Rapid developement of high power semiconductor devices with fast control features have given birth to several Flexible AC Transmission Systems (FACTS) controllers for improving power system performances. One of the advanced FACTS Controllers is Unified Power Flow Controller (UPFC), which can control power flows, both real and reactive in Transmission line. This paper presents performance analysis of UPFC based on d-q axis theory. So far the standard practise of realizing the UPFC has been confined to connecting two inverters back to back with a DC link capacitor in between. This capacitor brings with it several disadvantages which affects the overall reliability of the UPFC. The Matrix Converter (MC) topology comes without any such bulky reactive element except for lighter components as filters. This paper examines the effectiveness of MC as UPFC and simulation results shows a comparable performance with the traditional back to back constructs.

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        The Effects of Altered Membrane Cholesterol Levels on Sodium Pump Activity in Subclinical Hypothyroidism

        Suparna Roy,Anindya Dasgupta 대한내분비학회 2017 Endocrinology and metabolism Vol.32 No.1

        Background: Metabolic dysfunctions characteristic of overt hypothyroidism (OH) start at the early stage of subclinical hypothyroidism(SCH). Na+/K+-ATPase (the sodium pump) is a transmembrane enzyme that plays a vital role in cellular activities in combinationwith membrane lipids. We evaluated the effects of early changes in thyroid hormone and membrane cholesterol on sodiumpump activity in SCH and OH patients. Methods: In 32 SCH patients, 35 OH patients, and 34 euthyroid patients, sodium pump activity and cholesterol levels in red bloodcell membranes were measured. Serum thyroxine (T4) and thyroid stimulating hormone (TSH) levels were measured using enzymelinkedimmunosorbent assays. Differences in their mean values were analysed using post hoc analysis of variance. We assessed thedependence of the sodium pump on other metabolites by multiple regression analysis. Results: Sodium pump activity and membrane cholesterol were lower in both hypothyroid groups than in control group, OH groupexhibiting lower values than SCH group. In SCH group, sodium pump activity showed a significant direct dependence on membranecholesterol with an inverse relationship with serum TSH levels. In OH group, sodium pump activity depended directly on membranecholesterol and serum T4 levels. No dependence on serum cholesterol was observed in either case. Conclusion: Despite the presence of elevated serum cholesterol in hypothyroidism, membrane cholesterol contributed significantlyto maintain sodium pump activity in the cells. A critical reduction in membrane cholesterol levels heralds compromised enzyme activity,even in the early stage of hypothyroidism, and this can be predicted by elevated TSH levels alone, without any evident clinicalmanifestations.

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