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RISS 인기검색어
- 검색키워드
- 저자 : Alondra Lopez (검색결과 2 건)
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Inverse behavior of IL-23R and IL-17RA in chronic and aggressive periodontitis
Ruiz-Gutierrez, Alondra del Carmen,Rodriguez-Montano, Ruth,Pita-Lopez, Maria Luisa,Zamora-Perez, Ana Lourdes,Guerrero-Velazquez, Celia Korean Academy of Periodontology 2021 Journal of Periodontal & Implant Science Vol.51 No.4
Purpose: Periodontitis is associated with a dysbiosis of periodontopathic bacteria, which stimulate the interleukin (IL)-23/IL-17 axis that plays an essential role in the immunopathogenesis of this disease, leading to alveolar bone destruction through receptor activator of nuclear factor κB ligand (RANKL). IL-23 receptor mRNA (IL-23R) has been identified in periodontitis, and IL-17 receptor A mRNA (IL-17RA) and its protein have not yet been evaluated in patients with periodontitis. In this study was measure IL-23R and IL-17RA in gingival tissue (GT) from patients with generalized chronic periodontitis (GCP) and generalized aggressive periodontitis (GAP) and to explore correlations with clinical parameters. Methods: We included 16 healthy subjects (HS), 18 patients with GCP, and 14 with GAP. GT samples were collected during periodontal surgery. Both IL-23R and IL-17RA were detected by enzyme-linked immunosorbent assay. Results: The results were analyzed with Mann-Whitney U test and Spearman' rank correlation coefficients using SPSS version 25.0. We found lower IL-23R levels in patients with GCP and GAP than in HS. Contrarily, we observed higher IL-17RA levels in GCP and GAP patients than in HS. Moreover, we found negative correlations between IL-23R in GT and probing depth and clinical attachment loss (CAL). Likewise, a positive correlation of IL-17RA in GT with CAL was found. Conclusions: The results of these findings suggest that the reverse behavior between IL-23R and IL-17RA in periodontitis patients may also be involved with the activation of RANKL, which promotes alveolar bone loss.
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Prediabetes and Diabetes in Predominately Hispanic College Students
Juan Gonzalez,황인선,Jung-Il Oh,Alayna Mora,Alondra Lopez,이광용 한국웰니스학회 2023 한국웰니스학회지 Vol.18 No.3
Due to the high rate of adult-onset type 2 diabetes in South Texas, the purpose of this study was to investigate the prevalence of prediabetes and diabetes among college age students 18-30 years old between colleges at a predominantly Hispanic institution. De-identified blood biomarker data was quantitatively analyzed and compared with the American Diabetes Association(ADA) prediabetes and diabetes 2015 criteria. The significance of this research targets a young population where early intervention would be most effective. De-identified blood biomarkers such as fasting glucose levels and hemoglobin HgA1c levels, along with BMI were analyzed. These results were organized by genders and colleges across campus. This research was reviewed and approved by the university Institutional Review Board. Results for males(n=68) measured fasting glucose (96.25±27.52mg/dL), HgA1c levels(5.772±1.050%), as well as BMI(32.41±9.302). Data for females(n=152) measured fasting glucose(92.56±27.23mg/dL), HgA1c(5.744±0.922%), and BMI (32.72±9.060). Students across genders and colleges on campus at a predominantly Hispanic institution were below the blood biomarker levels that define diabetes. However, students are at risk for prediabetes according to the 2015 ADA prediabetes HgA1c criteria. Results indicated that 5 out of the 7 colleges on campus were prediabetic according to the HgA1c levels reported. This is a significant finding and suggests that an early surveillance mechanism is recommended for the Hispanic college age population in South Texas.
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